DE69735722D1 - D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen - Google Patents
D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungenInfo
- Publication number
- DE69735722D1 DE69735722D1 DE69735722T DE69735722T DE69735722D1 DE 69735722 D1 DE69735722 D1 DE 69735722D1 DE 69735722 T DE69735722 T DE 69735722T DE 69735722 T DE69735722 T DE 69735722T DE 69735722 D1 DE69735722 D1 DE 69735722D1
- Authority
- DE
- Germany
- Prior art keywords
- methionine
- platin
- platinum
- reduce toxicity
- antitumor compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 4
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 229910052697 platinum Inorganic materials 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 229930182818 D-methionine Natural products 0.000 abstract 1
- 206010059024 Gastrointestinal toxicity Diseases 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 206010029350 Neurotoxicity Diseases 0.000 abstract 1
- 206010044221 Toxic encephalopathy Diseases 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 231100000414 gastrointestinal toxicity Toxicity 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 231100000228 neurotoxicity Toxicity 0.000 abstract 1
- 230000007135 neurotoxicity Effects 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
- 208000016261 weight loss Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2775096P | 1996-10-03 | 1996-10-03 | |
| US27750P | 1996-10-03 | ||
| PCT/US1997/018114 WO1998014182A1 (en) | 1996-10-03 | 1997-10-02 | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735722D1 true DE69735722D1 (de) | 2006-05-24 |
| DE69735722T2 DE69735722T2 (de) | 2007-04-12 |
Family
ID=21839569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735722T Expired - Lifetime DE69735722T2 (de) | 1996-10-03 | 1997-10-02 | D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0930877B1 (de) |
| JP (1) | JP4260889B2 (de) |
| AT (1) | ATE323475T1 (de) |
| AU (1) | AU726392B2 (de) |
| CA (1) | CA2265983C (de) |
| DE (1) | DE69735722T2 (de) |
| DK (1) | DK0930877T3 (de) |
| ES (1) | ES2263172T3 (de) |
| PT (1) | PT930877E (de) |
| WO (1) | WO1998014182A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7071230B2 (en) | 1997-10-02 | 2006-07-04 | Board Of Trustees Of Southern Illinois University | Therapeutic use of D-methionine to reduce the toxicity of noise |
| KR20040048900A (ko) * | 2001-09-24 | 2004-06-10 | 토스크, 인코포레이티드 | 감소된 독성 시스플라틴 포뮬레이션 및 이의 이용 방법 |
| US20050090551A1 (en) * | 2003-10-27 | 2005-04-28 | Board Of Trustees Of Southern Illinois University | Therapeutic use of methionine for the treatment or prevention of mucositis |
| JP6295278B2 (ja) * | 2013-02-28 | 2018-03-14 | アニダ ファーマ インコーポレイテッド | 聴器毒性を治療する方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69322251T2 (de) * | 1992-09-04 | 1999-07-29 | Fuji Chem Ind Co Ltd | Medizinische zusammensetzung |
-
1997
- 1997-10-02 PT PT97911634T patent/PT930877E/pt unknown
- 1997-10-02 ES ES97911634T patent/ES2263172T3/es not_active Expired - Lifetime
- 1997-10-02 AT AT97911634T patent/ATE323475T1/de not_active IP Right Cessation
- 1997-10-02 WO PCT/US1997/018114 patent/WO1998014182A1/en active IP Right Grant
- 1997-10-02 JP JP51697398A patent/JP4260889B2/ja not_active Expired - Fee Related
- 1997-10-02 AU AU48957/97A patent/AU726392B2/en not_active Ceased
- 1997-10-02 DK DK97911634T patent/DK0930877T3/da active
- 1997-10-02 EP EP97911634A patent/EP0930877B1/de not_active Expired - Lifetime
- 1997-10-02 CA CA002265983A patent/CA2265983C/en not_active Expired - Fee Related
- 1997-10-02 DE DE69735722T patent/DE69735722T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2265983A1 (en) | 1998-04-09 |
| JP4260889B2 (ja) | 2009-04-30 |
| EP0930877B1 (de) | 2006-04-19 |
| PT930877E (pt) | 2006-09-29 |
| CA2265983C (en) | 2003-12-23 |
| AU726392B2 (en) | 2000-11-09 |
| WO1998014182A1 (en) | 1998-04-09 |
| DE69735722T2 (de) | 2007-04-12 |
| ATE323475T1 (de) | 2006-05-15 |
| AU4895797A (en) | 1998-04-24 |
| EP0930877A1 (de) | 1999-07-28 |
| DK0930877T3 (da) | 2006-08-21 |
| JP2001501626A (ja) | 2001-02-06 |
| ES2263172T3 (es) | 2006-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R082 | Change of representative |
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