ATE303992T1 - Verfahren zur herstellung von nichtsteroidale glucocorticoidrezeptor- modulatoren - Google Patents
Verfahren zur herstellung von nichtsteroidale glucocorticoidrezeptor- modulatorenInfo
- Publication number
- ATE303992T1 ATE303992T1 AT01309057T AT01309057T ATE303992T1 AT E303992 T1 ATE303992 T1 AT E303992T1 AT 01309057 T AT01309057 T AT 01309057T AT 01309057 T AT01309057 T AT 01309057T AT E303992 T1 ATE303992 T1 AT E303992T1
- Authority
- AT
- Austria
- Prior art keywords
- nonsteroid
- producing
- receptor modulators
- glucocorticoid receptor
- glucocorticoid
- Prior art date
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/37—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings
- C07C35/42—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings derived from the phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/192—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24387300P | 2000-10-27 | 2000-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303992T1 true ATE303992T1 (de) | 2005-09-15 |
Family
ID=22920481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01309057T ATE303992T1 (de) | 2000-10-27 | 2001-10-25 | Verfahren zur herstellung von nichtsteroidale glucocorticoidrezeptor- modulatoren |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6570020B2 (de) |
| EP (1) | EP1201655B1 (de) |
| JP (1) | JP3887207B2 (de) |
| KR (1) | KR100505770B1 (de) |
| CN (2) | CN1290813C (de) |
| AR (1) | AR034699A1 (de) |
| AT (1) | ATE303992T1 (de) |
| AU (1) | AU784269B2 (de) |
| BR (1) | BR0104836A (de) |
| CA (1) | CA2360024C (de) |
| CZ (1) | CZ20013855A3 (de) |
| DE (1) | DE60113210T2 (de) |
| DK (1) | DK1201655T3 (de) |
| ES (1) | ES2246293T3 (de) |
| HU (1) | HUP0104534A3 (de) |
| IL (3) | IL146057A (de) |
| MX (1) | MXPA01010962A (de) |
| PL (1) | PL350347A1 (de) |
| RU (1) | RU2219170C2 (de) |
| SI (1) | SI1201655T1 (de) |
| TW (1) | TWI247740B (de) |
| YU (1) | YU75601A (de) |
| ZA (1) | ZA200108797B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| DE60120077T2 (de) * | 2000-10-28 | 2006-11-02 | Pfizer Products Inc., Groton | Modulatoren des Glucocorticoid-Rezeptors |
| SI1521733T1 (sl) * | 2002-07-08 | 2014-10-30 | Pfizer Products Inc. | Modulatorji glukokortikoidnega receptorja |
| US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
| US20060154910A1 (en) * | 2003-02-20 | 2006-07-13 | Bingaman David P | Use of steroids to treat ocular disorders |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| BRPI0416812A (pt) | 2003-11-21 | 2007-03-06 | Combinatorx Inc | métodos e reagentes para o tratamento de desordens inflamatórias |
| CN102816194A (zh) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
| TWI375676B (en) * | 2005-08-29 | 2012-11-01 | Msd Oss Bv | Non-steroidal glucocorticoid receptor modulators |
| BRPI0618643A2 (pt) | 2005-11-09 | 2011-09-06 | Combinatorx Inc | composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso |
| AU2008211613B2 (en) | 2007-02-02 | 2013-05-23 | Pfizer Products Inc. | Tricyclic compounds and their use as glucocorticoid receptor modulators |
| WO2008093236A1 (en) * | 2007-02-02 | 2008-08-07 | Pfizer Products Inc. | Tricyclic compounds and their use as glucocorticoid receptor modulators |
| US20100092479A1 (en) * | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| EP2935284A4 (de) | 2012-12-21 | 2016-04-27 | Abbvie Inc | Heterocyclische nuklearhormonrezeptormodulatoren |
| AU2016226451B2 (en) | 2015-03-02 | 2019-12-19 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonist and somatostatin analogues to treat ACTH-secreting tumors |
| SG11201707525TA (en) | 2015-03-30 | 2017-10-30 | Corcept Therapeutics Inc | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
| ES2865334T3 (es) | 2015-08-13 | 2021-10-15 | Corcept Therapeutics Inc | Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH |
| JP6749399B2 (ja) * | 2015-09-15 | 2020-09-02 | レオ ファーマ アクティーゼルスカブ | 局所薬物送達のための非ステロイド性グルココルチコイド受容体モジュレーター |
| KR102197526B1 (ko) | 2016-01-19 | 2020-12-31 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 이소성 쿠싱 증후군의 감별 진단 |
| CA3055076C (en) | 2017-03-31 | 2022-02-22 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| JP7670462B2 (ja) | 2017-06-20 | 2025-04-30 | コーセプト セラピューティクス， インコーポレイテッド | 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法 |
| US20220288091A1 (en) | 2019-03-18 | 2022-09-15 | Lynnette K. NIEMAN | Method for Improving Insulin Sensitivity |
| WO2022130015A2 (en) | 2020-12-18 | 2022-06-23 | Instil Bio (Uk) Limited | Processing of tumor infiltrating lymphocytes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL122740A (en) * | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| CA2372173A1 (en) * | 1999-04-30 | 2000-11-09 | Pfizer Products Inc. | Glucocorticoid receptor modulators |
| IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| DE60120077T2 (de) * | 2000-10-28 | 2006-11-02 | Pfizer Products Inc., Groton | Modulatoren des Glucocorticoid-Rezeptors |
| ES2246292T3 (es) * | 2000-10-30 | 2006-02-16 | Pfizer Products Inc. | Moduladores de receptor glucocorticoide. |
-
2001
- 2001-10-18 IL IL146057A patent/IL146057A/en active IP Right Grant
- 2001-10-18 IL IL180679A patent/IL180679A0/en unknown
- 2001-10-22 US US10/008,619 patent/US6570020B2/en not_active Expired - Fee Related
- 2001-10-23 YU YU75601A patent/YU75601A/sh unknown
- 2001-10-25 DK DK01309057T patent/DK1201655T3/da active
- 2001-10-25 PL PL01350347A patent/PL350347A1/xx not_active Application Discontinuation
- 2001-10-25 ES ES01309057T patent/ES2246293T3/es not_active Expired - Lifetime
- 2001-10-25 AU AU83622/01A patent/AU784269B2/en not_active Ceased
- 2001-10-25 AT AT01309057T patent/ATE303992T1/de not_active IP Right Cessation
- 2001-10-25 CA CA002360024A patent/CA2360024C/en not_active Expired - Fee Related
- 2001-10-25 SI SI200130420T patent/SI1201655T1/sl unknown
- 2001-10-25 EP EP01309057A patent/EP1201655B1/de not_active Expired - Lifetime
- 2001-10-25 ZA ZA200108797A patent/ZA200108797B/xx unknown
- 2001-10-25 DE DE60113210T patent/DE60113210T2/de not_active Expired - Fee Related
- 2001-10-26 AR ARP010105025A patent/AR034699A1/es active IP Right Grant
- 2001-10-26 CZ CZ20013855A patent/CZ20013855A3/cs unknown
- 2001-10-26 JP JP2001329529A patent/JP3887207B2/ja not_active Expired - Fee Related
- 2001-10-26 TW TW090126630A patent/TWI247740B/zh not_active IP Right Cessation
- 2001-10-26 KR KR10-2001-0066290A patent/KR100505770B1/ko not_active Expired - Fee Related
- 2001-10-26 MX MXPA01010962A patent/MXPA01010962A/es active IP Right Grant
- 2001-10-26 CN CNB2005100045268A patent/CN1290813C/zh not_active Expired - Fee Related
- 2001-10-26 HU HU0104534A patent/HUP0104534A3/hu unknown
- 2001-10-26 CN CNB011355964A patent/CN1227232C/zh not_active Expired - Fee Related
- 2001-10-29 BR BR0104836-8A patent/BR0104836A/pt not_active IP Right Cessation
- 2001-11-19 RU RU2001131115/04A patent/RU2219170C2/ru not_active IP Right Cessation
-
2002
- 2002-10-15 US US10/271,309 patent/US6727392B2/en not_active Expired - Fee Related
-
2007
- 2007-07-16 IL IL184642A patent/IL184642A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1201655 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |