MX393313B - Metodos de tratamiento de tumores neuroepiteliales usando moduladores selectivos del receptor de glucocorticoide. - Google Patents
Metodos de tratamiento de tumores neuroepiteliales usando moduladores selectivos del receptor de glucocorticoide.Info
- Publication number
- MX393313B MX393313B MX2019015385A MX2019015385A MX393313B MX 393313 B MX393313 B MX 393313B MX 2019015385 A MX2019015385 A MX 2019015385A MX 2019015385 A MX2019015385 A MX 2019015385A MX 393313 B MX393313 B MX 393313B
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- sgrm
- tumor
- glucocorticoid receptor
- neuroepithelial
- Prior art date
Links
- 208000027831 neuroepithelial neoplasm Diseases 0.000 title abstract 5
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 abstract 2
- 101800000414 Corticotropin Proteins 0.000 abstract 2
- 102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 2
- 229960000258 corticotropin Drugs 0.000 abstract 2
- 230000003637 steroidlike Effects 0.000 abstract 2
- YJDDXMSIMBMMGY-UHFFFAOYSA-N 2-cyclohexylpyrimidine Chemical compound C1CCCCC1C1=NC=CC=N1 YJDDXMSIMBMMGY-UHFFFAOYSA-N 0.000 abstract 1
- 206010014967 Ependymoma Diseases 0.000 abstract 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
- 102000007517 Neurofibromin 2 Human genes 0.000 abstract 1
- 108010085839 Neurofibromin 2 Proteins 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 heteroaryl ketone Chemical class 0.000 abstract 1
- 206010027191 meningioma Diseases 0.000 abstract 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical group C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 abstract 1
- 229960003248 mifepristone Drugs 0.000 abstract 1
- 208000007538 neurilemmoma Diseases 0.000 abstract 1
- 208000002761 neurofibromatosis 2 Diseases 0.000 abstract 1
- 208000022032 neurofibromatosis type 2 Diseases 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 206010039667 schwannoma Diseases 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El solicitante divulga métodos para tratar un tumor neuroepitelial positivo para el receptor de glucocorticoide (GR+) en un sujeto, que comprende administrar un modulador selectivo del receptor de glucocorticoide (SGRM) en una cantidad eficaz para reducir la carga tumoral en un sujeto. El tumor neuroepitelial GR+ puede ser un tumor de neurofibromatosis de tipo 2 (NF2); el tumor neuroepitelial GR+ puede ser un schwannoma, meningioma o ependimoma. En unas modalidades, el tumor neuroepitelial GR+ no es un tumor que secreta la hormona adrenocorticotrópica (ACTH). En unas modalidades, el SGRM comprende un esqueleto esteroideo. En unas modalidades, el SGRM es mifepristona. En unas modalidades, el SGRM comprende un esqueleto no esteroideo, tal como por ejemplo un esqueleto de ciclohexil-pirimidina, una azadecalina fusionada, una heteroaril-cetona-azadecalina fusionada o una octahidroazadecalina fusionada. El SGRM se puede administrar por vía oral. El SGRM se puede administrar solo. En unas modalidades, el SGRM se administra con el menos una terapia no SGRM, por ejemplo, una quimioterapia, una terapia de radiación u otros agentes terapéuticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762522489P | 2017-06-20 | 2017-06-20 | |
| PCT/US2018/038075 WO2018236749A2 (en) | 2017-06-20 | 2018-06-18 | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX393313B true MX393313B (es) | 2025-03-24 |
Family
ID=64737393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019015385A MX393313B (es) | 2017-06-20 | 2018-06-18 | Metodos de tratamiento de tumores neuroepiteliales usando moduladores selectivos del receptor de glucocorticoide. |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11213526B2 (es) |
| EP (1) | EP3641780B1 (es) |
| JP (3) | JP7670462B2 (es) |
| AU (1) | AU2018289307B2 (es) |
| CA (1) | CA3065555A1 (es) |
| ES (1) | ES3043682T3 (es) |
| MX (1) | MX393313B (es) |
| WO (1) | WO2018236749A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX393313B (es) | 2017-06-20 | 2025-03-24 | Corcept Therapeutics Inc | Metodos de tratamiento de tumores neuroepiteliales usando moduladores selectivos del receptor de glucocorticoide. |
| CA3102099C (en) | 2018-06-04 | 2023-09-26 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
| KR20210119980A (ko) | 2019-01-22 | 2021-10-06 | 아크리베스 바이오메디컬 게엠베하 | 손상된 피부 상처를 치료하기 위한 선택적 글루코코르티코이드 수용체 개질제 |
| WO2021226260A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| IL297840A (en) | 2020-05-06 | 2023-01-01 | Corcept Therapeutics Inc | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| CN116848092A (zh) | 2020-12-21 | 2023-10-03 | 科赛普特治疗公司 | 制备嘧啶环己基糖皮质激素受体调节剂的方法 |
| WO2024050500A1 (en) * | 2022-09-02 | 2024-03-07 | Corcept Therapeutics Incorporated | Methods of assessing selective glucocorticoid receptor modulation and of identifying and treating patients likely to benefit from glucocorticoid receptor modulation |
| WO2025255357A1 (en) * | 2024-06-06 | 2025-12-11 | Corcept Therapeutics Incorporated | Methods for preparing and maintaining livers and portions thereof for liver transplantation |
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| FR2639045B2 (fr) | 1982-03-01 | 1994-07-29 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments |
| FR2522328B1 (fr) | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
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| MX393313B (es) * | 2017-06-20 | 2025-03-24 | Corcept Therapeutics Inc | Metodos de tratamiento de tumores neuroepiteliales usando moduladores selectivos del receptor de glucocorticoide. |
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2018
- 2018-06-18 MX MX2019015385A patent/MX393313B/es unknown
- 2018-06-18 ES ES18821665T patent/ES3043682T3/es active Active
- 2018-06-18 EP EP18821665.9A patent/EP3641780B1/en active Active
- 2018-06-18 US US16/620,832 patent/US11213526B2/en active Active
- 2018-06-18 CA CA3065555A patent/CA3065555A1/en active Pending
- 2018-06-18 WO PCT/US2018/038075 patent/WO2018236749A2/en not_active Ceased
- 2018-06-18 JP JP2019570000A patent/JP7670462B2/ja active Active
- 2018-06-18 AU AU2018289307A patent/AU2018289307B2/en active Active
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2021
- 2021-11-19 US US17/531,682 patent/US11793810B2/en active Active
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2022
- 2022-08-30 JP JP2022136739A patent/JP2022164775A/ja active Pending
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2023
- 2023-09-15 US US18/369,071 patent/US12263169B2/en active Active
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2025
- 2025-02-20 JP JP2025026258A patent/JP2025071259A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3641780A2 (en) | 2020-04-29 |
| US20200147082A1 (en) | 2020-05-14 |
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| WO2018236749A2 (en) | 2018-12-27 |
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