ATE296446T1 - Modulatoren von insulinrezeptor-aktivität - Google Patents
Modulatoren von insulinrezeptor-aktivitätInfo
- Publication number
- ATE296446T1 ATE296446T1 AT98903515T AT98903515T ATE296446T1 AT E296446 T1 ATE296446 T1 AT E296446T1 AT 98903515 T AT98903515 T AT 98903515T AT 98903515 T AT98903515 T AT 98903515T AT E296446 T1 ATE296446 T1 AT E296446T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin receptor
- stimulates
- independently
- insulin
- compounds
- Prior art date
Links
- 102000003746 Insulin Receptor Human genes 0.000 title abstract 6
- 108010001127 Insulin Receptor Proteins 0.000 title abstract 6
- 230000000694 effects Effects 0.000 title abstract 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 102000058061 Glucose Transporter Type 4 Human genes 0.000 abstract 1
- 102100025087 Insulin receptor substrate 1 Human genes 0.000 abstract 1
- 101710201824 Insulin receptor substrate 1 Proteins 0.000 abstract 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 1
- 108091006300 SLC2A4 Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000008727 cellular glucose uptake Effects 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 230000004190 glucose uptake Effects 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001151 other effect Effects 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78485597A | 1997-01-15 | 1997-01-15 | |
| US08/784,857 US5830918A (en) | 1997-01-15 | 1997-01-15 | Nonpeptide insulin receptor agonists |
| US08/784,854 US5851988A (en) | 1997-01-15 | 1997-01-15 | Nonpeptide insulin receptor agonists |
| US82526997A | 1997-03-27 | 1997-03-27 | |
| US08/916,088 US6329431B1 (en) | 1997-01-15 | 1997-08-21 | Nonpeptide insulin receptor agonists |
| PCT/US1998/000801 WO1998032017A2 (en) | 1997-01-15 | 1998-01-15 | Modulators of insulin receptor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296446T1 true ATE296446T1 (de) | 2005-06-15 |
Family
ID=27542207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98903515T ATE296446T1 (de) | 1997-01-15 | 1998-01-15 | Modulatoren von insulinrezeptor-aktivität |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0960335B1 (enExample) |
| JP (1) | JP2002512685A (enExample) |
| AT (1) | ATE296446T1 (enExample) |
| AU (1) | AU6026698A (enExample) |
| CA (1) | CA2278023A1 (enExample) |
| DE (1) | DE69830301T2 (enExample) |
| DK (1) | DK0960335T3 (enExample) |
| ES (1) | ES2242995T3 (enExample) |
| WO (1) | WO1998032017A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875741B2 (en) * | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
| AU6059099A (en) | 1998-09-25 | 2000-04-17 | Children's Medical Center Corporation | Short peptides which selectively modulate the activity of protein kinases |
| TWI234557B (en) * | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
| US7181349B1 (en) * | 1999-05-27 | 2007-02-20 | Cecil Yip | Identification of compounds for modulating dimeric receptors |
| JP2003507361A (ja) * | 1999-07-29 | 2003-02-25 | テリック，インコーポレイテッド | グルコース取り込みアゴニストとしての新規ナフチルスルホン酸および関連化合物 |
| FR2797767B1 (fr) | 1999-08-27 | 2002-06-14 | Centre Nat Rech Scient | Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances |
| JP2004512010A (ja) * | 2000-03-29 | 2004-04-22 | ディージーアイ・バイオテクノロジーズ・エル・エル・シー | インスリン及びｉｇｆ−１受容体のアゴニスト及びアンタゴニスト |
| JP2005500813A (ja) * | 2001-01-12 | 2005-01-13 | エクセリクシス・インコーポレイテッド | インスリン受容体シグナル伝達の調節 |
| EP1510207A4 (en) * | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC MEDICAMENT AGAINST DIABETES |
| AU2003242127A1 (en) * | 2002-06-05 | 2003-12-22 | Institute Of Medicinal Molecular Design, Inc. | Inhibitors against the activation of ap-1 and nfat |
| US20060122243A1 (en) * | 2002-06-06 | 2006-06-08 | Susumu Muto | Antiallergic |
| JP4743382B2 (ja) * | 2002-06-06 | 2011-08-10 | 株式会社医薬分子設計研究所 | Ｏ−置換ヒドロキシアリール誘導体 |
| WO2003103655A1 (ja) * | 2002-06-10 | 2003-12-18 | 株式会社医薬分子設計研究所 | 癌治療剤 |
| EP1535609A4 (en) * | 2002-06-10 | 2009-01-07 | Inst Med Molecular Design Inc | Nf-kb activation inhibitors |
| DE10323081A1 (de) * | 2003-05-22 | 2004-12-16 | Aventis Pharma Deutschland Gmbh | Verwendung eines Polypeptides |
| EP1885855A4 (en) * | 2005-05-05 | 2009-03-04 | Valorisation Hsj Soc En Comman | CYTOKIN RECEPTOR MODULATORS AND USES THEREOF |
| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1812595A (en) * | 1994-02-28 | 1995-09-11 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Cell lines for the identification of substances affecting insulin receptor mediated signal transduction |
| EP0817967A4 (en) * | 1995-03-31 | 2000-05-17 | Merck & Co Inc | TEST FOR INSULIN-IMITATING AND REINFORCING SUBSTANCES |
-
1998
- 1998-01-15 JP JP53453298A patent/JP2002512685A/ja not_active Ceased
- 1998-01-15 AT AT98903515T patent/ATE296446T1/de not_active IP Right Cessation
- 1998-01-15 WO PCT/US1998/000801 patent/WO1998032017A2/en not_active Ceased
- 1998-01-15 ES ES98903515T patent/ES2242995T3/es not_active Expired - Lifetime
- 1998-01-15 EP EP98903515A patent/EP0960335B1/en not_active Expired - Lifetime
- 1998-01-15 CA CA002278023A patent/CA2278023A1/en not_active Abandoned
- 1998-01-15 DE DE69830301T patent/DE69830301T2/de not_active Expired - Fee Related
- 1998-01-15 AU AU60266/98A patent/AU6026698A/en not_active Abandoned
- 1998-01-15 DK DK98903515T patent/DK0960335T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002512685A (ja) | 2002-04-23 |
| EP0960335A2 (en) | 1999-12-01 |
| CA2278023A1 (en) | 1998-07-23 |
| DE69830301D1 (de) | 2005-06-30 |
| WO1998032017A3 (en) | 1999-02-25 |
| AU6026698A (en) | 1998-08-07 |
| ES2242995T3 (es) | 2005-11-16 |
| DE69830301T2 (de) | 2006-02-02 |
| DK0960335T3 (da) | 2005-06-20 |
| EP0960335B1 (en) | 2005-05-25 |
| WO1998032017A2 (en) | 1998-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |