EP0817967A4 - Insulin mimetic and enhancer assay - Google Patents

Insulin mimetic and enhancer assay

Info

Publication number
EP0817967A4
EP0817967A4 EP96910609A EP96910609A EP0817967A4 EP 0817967 A4 EP0817967 A4 EP 0817967A4 EP 96910609 A EP96910609 A EP 96910609A EP 96910609 A EP96910609 A EP 96910609A EP 0817967 A4 EP0817967 A4 EP 0817967A4
Authority
EP
European Patent Office
Prior art keywords
insulin mimetic
enhancer assay
enhancer
assay
mimetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96910609A
Other languages
German (de)
French (fr)
Other versions
EP0817967A1 (en
Inventor
Bei Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0817967A1 publication Critical patent/EP0817967A1/en
Publication of EP0817967A4 publication Critical patent/EP0817967A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
EP96910609A 1995-03-31 1996-03-27 Insulin mimetic and enhancer assay Withdrawn EP0817967A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41497695A 1995-03-31 1995-03-31
US414976 1995-03-31
PCT/US1996/004226 WO1996030762A1 (en) 1995-03-31 1996-03-27 Insulin mimetic and enhancer assay

Publications (2)

Publication Number Publication Date
EP0817967A1 EP0817967A1 (en) 1998-01-14
EP0817967A4 true EP0817967A4 (en) 2000-05-17

Family

ID=23643820

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96910609A Withdrawn EP0817967A4 (en) 1995-03-31 1996-03-27 Insulin mimetic and enhancer assay

Country Status (4)

Country Link
EP (1) EP0817967A4 (en)
JP (1) JPH11503519A (en)
CA (1) CA2216806A1 (en)
WO (1) WO1996030762A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786488A (en) 1996-11-13 1998-07-28 Sugen, Inc. Synthetic methods for the preparation of indolyquinones
US6376529B1 (en) 1995-06-07 2002-04-23 Peng Cho Tang Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
US5851988A (en) 1997-01-15 1998-12-22 Terrapin Technologies, Inc. Nonpeptide insulin receptor agonists
CA2278023A1 (en) * 1997-01-15 1998-07-23 Telik, Inc. Modulators of insulin receptor activity
US6884597B1 (en) 1998-01-20 2005-04-26 Medical & Biological Laboratories, Co., Ltd. Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes
US20050170343A1 (en) * 2001-01-12 2005-08-04 Cynthnia Seidel-Dugan Modulating insulin receptor signaling
DE10149668A1 (en) * 2001-10-09 2003-04-10 Numico Res B V New insulin mimetic amino acid sequences, known as exsulins, useful for e.g. treating hyperinsulinemia, diabetes mellitus, autoimmune diseases or neurodegenerative diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019570A1 (en) * 1994-01-14 1995-07-20 Genentech, Inc. Antagonists to insulin receptor tyrosine kinase inhibitor
WO1995023231A1 (en) * 1994-02-28 1995-08-31 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cell lines for the identification of substances affecting insulin receptor mediated signal transduction
WO1995023217A2 (en) * 1994-02-28 1995-08-31 Max Planck Gesellschaft Treatment of diabetes mellitus and insulin receptor signal transduction
WO1996014075A1 (en) * 1994-11-07 1996-05-17 University Of Virginia Patent Foundation Synthetic insulin mimetic substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536517A (en) * 1983-04-25 1985-08-20 American Cyanamid Company Method of treating diabetes mellitus using arylglyoxals
US5405855A (en) * 1993-12-23 1995-04-11 Andrulis Pharmaceuticals Corp. Treatment of insulin resistant diabetes with thalidomine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019570A1 (en) * 1994-01-14 1995-07-20 Genentech, Inc. Antagonists to insulin receptor tyrosine kinase inhibitor
WO1995023231A1 (en) * 1994-02-28 1995-08-31 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cell lines for the identification of substances affecting insulin receptor mediated signal transduction
WO1995023217A2 (en) * 1994-02-28 1995-08-31 Max Planck Gesellschaft Treatment of diabetes mellitus and insulin receptor signal transduction
WO1996014075A1 (en) * 1994-11-07 1996-05-17 University Of Virginia Patent Foundation Synthetic insulin mimetic substances

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO9630762A1 *
ZHANG B. ET AL: "Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1994) 269/41 (25735-25741)., XP000872885 *
ZHANG B., ROTH R. A.: "The insulin receptor-related Receptor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 26, 25 September 1992 (1992-09-25), pages 18320 - 18328, XP000872876 *

Also Published As

Publication number Publication date
JPH11503519A (en) 1999-03-26
EP0817967A1 (en) 1998-01-14
CA2216806A1 (en) 1996-10-03
WO1996030762A1 (en) 1996-10-03

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