ATE289587T1 - 2-amino-2-alkyl-5-heptensäure und heptynsäure derivate als inhibitoren der stickstoffmonoxid- synthase - Google Patents

2-amino-2-alkyl-5-heptensäure und heptynsäure derivate als inhibitoren der stickstoffmonoxid- synthase

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Publication number
ATE289587T1
ATE289587T1 AT01970937T AT01970937T ATE289587T1 AT E289587 T1 ATE289587 T1 AT E289587T1 AT 01970937 T AT01970937 T AT 01970937T AT 01970937 T AT01970937 T AT 01970937T AT E289587 T1 ATE289587 T1 AT E289587T1
Authority
AT
Austria
Prior art keywords
acid
inhibitors
amino
alkyl
heptynic
Prior art date
Application number
AT01970937T
Other languages
English (en)
Inventor
Donald Hansen Jr
Ronald Keith Webber
Barnett S Pitzele
James Sikorski
Mark A Massa
Timothy J Hagen
Margaret Grapperhaus
Lijuan Jane Wang
Arija A Bergmanis
Steven W Kramer
E Ann Hallinan
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE289587T1 publication Critical patent/ATE289587T1/de

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
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    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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AT01970937T 2000-09-15 2001-09-15 2-amino-2-alkyl-5-heptensäure und heptynsäure derivate als inhibitoren der stickstoffmonoxid- synthase ATE289587T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23268300P 2000-09-15 2000-09-15
PCT/US2001/028673 WO2002022562A1 (en) 2000-09-15 2001-09-15 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
ATE289587T1 true ATE289587T1 (de) 2005-03-15

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AT01970937T ATE289587T1 (de) 2000-09-15 2001-09-15 2-amino-2-alkyl-5-heptensäure und heptynsäure derivate als inhibitoren der stickstoffmonoxid- synthase

Country Status (26)

Country Link
US (2) US6951889B2 (de)
EP (1) EP1317421B1 (de)
JP (1) JP5009480B2 (de)
KR (1) KR100840981B1 (de)
CN (1) CN1301966C (de)
AR (1) AR030741A1 (de)
AT (1) ATE289587T1 (de)
AU (2) AU2001290883A1 (de)
BR (1) BR0113925A (de)
CA (1) CA2421504C (de)
CY (1) CY1106056T1 (de)
CZ (1) CZ2003646A3 (de)
DE (1) DE60109046T2 (de)
DK (1) DK1317421T3 (de)
EA (1) EA006244B1 (de)
ES (1) ES2238477T3 (de)
IL (2) IL154841A0 (de)
MX (1) MXPA03002207A (de)
MY (1) MY131964A (de)
NO (1) NO20031140L (de)
NZ (1) NZ524562A (de)
PL (1) PL207391B1 (de)
PT (1) PT1317421E (de)
SI (1) SI1317421T1 (de)
TW (1) TWI290130B (de)
WO (1) WO2002022562A1 (de)

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AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
AU2003232148A1 (en) * 2002-05-16 2003-12-02 Pharmacia Corporation A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases
CN1652843A (zh) * 2002-05-16 2005-08-10 法玛西雅公司 使用选择性iNOS抑制剂治疗呼吸系统疾病和病症
KR20050059051A (ko) * 2002-08-02 2005-06-17 파마시아 코포레이션 위장 증상의 치료 및 예방 방법
ES2384969T3 (es) 2002-08-23 2012-07-16 Pharmacia Corporation Forma sólida cristalina del ácido (2S-5Z)-2-amino-7-(etanimidoilamino)-2-metilhept-5-enoico
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US20040235139A1 (en) * 2002-12-23 2004-11-25 Demain Arnold L. Clostridium difficile culture and toxin production methods
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
CA2611105A1 (en) * 2005-06-09 2006-12-21 Mallinckrodt Inc. Method for separation and purification of naltrexone by preparative chromatography
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
US9895324B2 (en) * 2014-03-26 2018-02-20 University Of Kentucky Research Foundation Halogenated diarylacetylenes and methods of treating cancer
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds
EP3398941A1 (de) * 2017-05-03 2018-11-07 AXXAM S.p.A. Heterozyklische p2x7-antagonisten
CN113861064B (zh) * 2021-10-14 2024-05-10 南京医科大学 一类神经保护剂及其药物用途
CN116693389B (zh) * 2023-06-15 2025-09-23 新元果业(山东)集团有限公司 一种合成番茄潜叶蛾性信息素(3e,8z)-3,8-十四碳二烯乙酸酯的方法

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DK1317421T3 (da) 2005-06-27
US6951889B2 (en) 2005-10-04
MY131964A (en) 2007-09-28
KR20030069167A (ko) 2003-08-25
WO2002022562A1 (en) 2002-03-21
EP1317421A1 (de) 2003-06-11
MXPA03002207A (es) 2003-06-24
AU2007203823A1 (en) 2007-09-06
HK1062910A1 (en) 2004-12-03
CN1301966C (zh) 2007-02-28
ES2238477T3 (es) 2005-09-01
PL207391B1 (pl) 2010-12-31
US20020132849A1 (en) 2002-09-19
TWI290130B (en) 2007-11-21
SI1317421T1 (de) 2005-08-31
PT1317421E (pt) 2005-07-29
NZ524562A (en) 2005-02-25
AU2007203823B2 (en) 2009-06-04
IL154841A0 (en) 2003-10-31
JP2004509099A (ja) 2004-03-25
JP5009480B2 (ja) 2012-08-22
BR0113925A (pt) 2003-07-01
NO20031140L (no) 2003-05-08
DE60109046D1 (de) 2005-03-31
NO20031140D0 (no) 2003-03-12
AU2001290883A1 (en) 2002-03-26
CZ2003646A3 (cs) 2003-10-15
US20050113451A1 (en) 2005-05-26
KR100840981B1 (ko) 2008-06-24
PL361137A1 (en) 2004-09-20
IL154841A (en) 2010-12-30
EA006244B1 (ru) 2005-10-27
AR030741A1 (es) 2003-09-03
DE60109046T2 (de) 2005-08-04
EP1317421B1 (de) 2005-02-23
EA200300377A1 (ru) 2003-10-30
CN1474805A (zh) 2004-02-11
CY1106056T1 (el) 2011-04-06
CA2421504C (en) 2009-11-24
CA2421504A1 (en) 2002-03-21

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