EA200300377A1 - Производные 2-амино-2-алкил-5-гептеновой и -гептиновой кислот, которые могут быть использованы в качестве ингибиторов синтетазы оксида азота - Google Patents

Производные 2-амино-2-алкил-5-гептеновой и -гептиновой кислот, которые могут быть использованы в качестве ингибиторов синтетазы оксида азота

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Publication number
EA200300377A1
EA200300377A1 EA200300377A EA200300377A EA200300377A1 EA 200300377 A1 EA200300377 A1 EA 200300377A1 EA 200300377 A EA200300377 A EA 200300377A EA 200300377 A EA200300377 A EA 200300377A EA 200300377 A1 EA200300377 A1 EA 200300377A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
acids
amino
alkyl
nitric oxide
Prior art date
Application number
EA200300377A
Other languages
English (en)
Other versions
EA006244B1 (ru
Inventor
Доналд Джр. Хансен
Роналд Кит Уэббер
Барнетт С. Питзеле
Джеймс Сикорски
Марк А. Масса
Тимоти Дж. Хейген
Маргарет Грапперхауз
Лиюань Джейн Ван
Ария А. Бергманис
Стивен У. Крамер
Анн Э. Халлинан
Original Assignee
Фармасиа Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармасиа Корпорейшн filed Critical Фармасиа Корпорейшн
Publication of EA200300377A1 publication Critical patent/EA200300377A1/ru
Publication of EA006244B1 publication Critical patent/EA006244B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
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    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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Abstract

В заявке описаны производные 2-амино-2-алкил-5-гептеновой и -гептиновой кислот и их применение в терапии, в частности их применение в качестве ингибиторов синтетазы оксида азота.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300377A 2000-09-15 2001-09-15 Производные 2-амино-2-алкил-5-гептеновой и -гептиновой кислот, которые могут быть использованы в качестве ингибиторов синтетазы оксида азота EA006244B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23268300P 2000-09-15 2000-09-15
PCT/US2001/028673 WO2002022562A1 (en) 2000-09-15 2001-09-15 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors

Publications (2)

Publication Number Publication Date
EA200300377A1 true EA200300377A1 (ru) 2003-10-30
EA006244B1 EA006244B1 (ru) 2005-10-27

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EA200300377A EA006244B1 (ru) 2000-09-15 2001-09-15 Производные 2-амино-2-алкил-5-гептеновой и -гептиновой кислот, которые могут быть использованы в качестве ингибиторов синтетазы оксида азота

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US (2) US6951889B2 (ru)
EP (1) EP1317421B1 (ru)
JP (1) JP5009480B2 (ru)
KR (1) KR100840981B1 (ru)
CN (1) CN1301966C (ru)
AR (1) AR030741A1 (ru)
AT (1) ATE289587T1 (ru)
AU (2) AU2001290883A1 (ru)
BR (1) BR0113925A (ru)
CA (1) CA2421504C (ru)
CY (1) CY1106056T1 (ru)
CZ (1) CZ2003646A3 (ru)
DE (1) DE60109046T2 (ru)
DK (1) DK1317421T3 (ru)
EA (1) EA006244B1 (ru)
ES (1) ES2238477T3 (ru)
HK (1) HK1062910A1 (ru)
IL (2) IL154841A0 (ru)
MX (1) MXPA03002207A (ru)
MY (1) MY131964A (ru)
NO (1) NO20031140L (ru)
NZ (1) NZ524562A (ru)
PL (1) PL207391B1 (ru)
PT (1) PT1317421E (ru)
SI (1) SI1317421T1 (ru)
TW (1) TWI290130B (ru)
WO (1) WO2002022562A1 (ru)

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US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
KR20050004155A (ko) * 2002-05-16 2005-01-12 파마시아 코포레이션 선택적 유도성 산화질소 신타아제 억제제를 이용한 호흡기질병 및 질환의 치료 방법
BR0310061A (pt) * 2002-05-16 2005-03-01 Pharmacia Corp Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições
BR0313204A (pt) * 2002-08-02 2005-06-28 Pharmacia Corp Métodos para tratamento e prevenção de condições gastrointestinais
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US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
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AU2007203823B2 (en) 2009-06-04
PL361137A1 (en) 2004-09-20
DK1317421T3 (da) 2005-06-27
CY1106056T1 (el) 2011-04-06
AR030741A1 (es) 2003-09-03
CA2421504A1 (en) 2002-03-21
EA006244B1 (ru) 2005-10-27
DE60109046D1 (de) 2005-03-31
JP5009480B2 (ja) 2012-08-22
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CA2421504C (en) 2009-11-24
PT1317421E (pt) 2005-07-29
EP1317421B1 (en) 2005-02-23
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NZ524562A (en) 2005-02-25
DE60109046T2 (de) 2005-08-04
WO2002022562A1 (en) 2002-03-21
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CZ2003646A3 (cs) 2003-10-15
TWI290130B (en) 2007-11-21
NO20031140D0 (no) 2003-03-12
US20020132849A1 (en) 2002-09-19
MY131964A (en) 2007-09-28
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CN1301966C (zh) 2007-02-28
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US20050113451A1 (en) 2005-05-26
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