ATE284400T1 - Ethanolsolvat von (-)-cis-2-(2-chlorphenyl)-5,7- dihydroxy-8- (4r-(3s-hydroxy-1- methyl)piperidinyl)-4h-1-benzopyran-4-on - Google Patents

Ethanolsolvat von (-)-cis-2-(2-chlorphenyl)-5,7- dihydroxy-8- (4r-(3s-hydroxy-1- methyl)piperidinyl)-4h-1-benzopyran-4-on

Info

Publication number
ATE284400T1
ATE284400T1 AT01902993T AT01902993T ATE284400T1 AT E284400 T1 ATE284400 T1 AT E284400T1 AT 01902993 T AT01902993 T AT 01902993T AT 01902993 T AT01902993 T AT 01902993T AT E284400 T1 ATE284400 T1 AT E284400T1
Authority
AT
Austria
Prior art keywords
chlorphenyl
benzopyran
piperidinyl
dihydroxy
cis
Prior art date
Application number
AT01902993T
Other languages
German (de)
English (en)
Inventor
Kurt M Kesseler
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE284400T1 publication Critical patent/ATE284400T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT01902993T 2000-01-18 2001-01-08 Ethanolsolvat von (-)-cis-2-(2-chlorphenyl)-5,7- dihydroxy-8- (4r-(3s-hydroxy-1- methyl)piperidinyl)-4h-1-benzopyran-4-on ATE284400T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48781500A 2000-01-18 2000-01-18
PCT/US2001/000520 WO2001053294A1 (en) 2000-01-18 2001-01-08 Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one

Publications (1)

Publication Number Publication Date
ATE284400T1 true ATE284400T1 (de) 2004-12-15

Family

ID=23937213

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01902993T ATE284400T1 (de) 2000-01-18 2001-01-08 Ethanolsolvat von (-)-cis-2-(2-chlorphenyl)-5,7- dihydroxy-8- (4r-(3s-hydroxy-1- methyl)piperidinyl)-4h-1-benzopyran-4-on

Country Status (26)

Country Link
EP (1) EP1252155B1 (cs)
JP (1) JP2003520798A (cs)
KR (1) KR100825530B1 (cs)
CN (1) CN1395577A (cs)
AR (1) AR027226A1 (cs)
AT (1) ATE284400T1 (cs)
AU (1) AU2001230869A1 (cs)
BR (1) BR0107724A (cs)
CA (1) CA2397594C (cs)
CZ (1) CZ301235B6 (cs)
DE (1) DE60107652T2 (cs)
DK (1) DK1252155T3 (cs)
EA (1) EA005182B1 (cs)
ES (1) ES2228800T3 (cs)
HU (1) HU225155B1 (cs)
IL (2) IL150643A0 (cs)
MX (1) MXPA02006965A (cs)
NO (1) NO322626B1 (cs)
NZ (1) NZ520281A (cs)
PL (1) PL201690B1 (cs)
PT (1) PT1252155E (cs)
SI (1) SI1252155T1 (cs)
SK (1) SK287216B6 (cs)
TW (1) TWI293072B (cs)
WO (1) WO2001053294A1 (cs)
ZA (1) ZA200205640B (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL264950B2 (en) 2016-08-23 2024-01-01 Eisai R&D Man Co Ltd Combined treatments for the treatment of malignant liver cell carcinoma
CA3056701A1 (en) 2017-03-16 2018-09-20 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (cs) * 1986-04-11 1989-02-04 Hoechst India
DE3836676A1 (de) * 1988-10-28 1990-05-03 Hoechst Ag Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs

Also Published As

Publication number Publication date
WO2001053294A1 (en) 2001-07-26
CA2397594A1 (en) 2001-07-26
NO20023385D0 (no) 2002-07-12
ZA200205640B (en) 2003-11-26
DE60107652T2 (de) 2005-12-22
CA2397594C (en) 2010-03-23
ES2228800T3 (es) 2005-04-16
EA005182B1 (ru) 2004-12-30
HUP0204297A2 (hu) 2003-04-28
CN1395577A (zh) 2003-02-05
NO20023385L (no) 2002-08-27
KR100825530B1 (ko) 2008-04-25
SK287216B6 (sk) 2010-03-08
TWI293072B (en) 2008-02-01
IL150643A (en) 2009-08-03
DE60107652D1 (de) 2005-01-13
EP1252155B1 (en) 2004-12-08
NZ520281A (en) 2004-04-30
JP2003520798A (ja) 2003-07-08
DK1252155T3 (da) 2005-04-04
PL201690B1 (pl) 2009-04-30
IL150643A0 (en) 2003-02-12
AU2001230869A1 (en) 2001-07-31
BR0107724A (pt) 2002-10-01
AR027226A1 (es) 2003-03-19
EP1252155A1 (en) 2002-10-30
CZ20022467A3 (cs) 2002-10-16
KR20020069514A (ko) 2002-09-04
HU225155B1 (en) 2006-07-28
PL355992A1 (en) 2004-05-31
HUP0204297A3 (en) 2005-04-28
PT1252155E (pt) 2005-04-29
SI1252155T1 (en) 2005-06-30
EA200200776A1 (ru) 2002-12-26
MXPA02006965A (es) 2004-09-06
SK10372002A3 (sk) 2002-12-03
CZ301235B6 (cs) 2009-12-16
NO322626B1 (no) 2006-11-06

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