ATE270301T1 - Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga - Google Patents

Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga

Info

Publication number
ATE270301T1
ATE270301T1 AT98915075T AT98915075T ATE270301T1 AT E270301 T1 ATE270301 T1 AT E270301T1 AT 98915075 T AT98915075 T AT 98915075T AT 98915075 T AT98915075 T AT 98915075T AT E270301 T1 ATE270301 T1 AT E270301T1
Authority
AT
Austria
Prior art keywords
nucleotide analogs
producing modified
chiral
chiral nucleotide
modified
Prior art date
Application number
AT98915075T
Other languages
English (en)
Inventor
Wojciech J Stec
Lucyna A Wozniak
Arkadiusz Chworos
Jaroslaw Pyzowski
Original Assignee
Ct Badan Molekular I Makro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Badan Molekular I Makro filed Critical Ct Badan Molekular I Makro
Application granted granted Critical
Publication of ATE270301T1 publication Critical patent/ATE270301T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT98915075T 1997-04-25 1998-04-23 Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga ATE270301T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL97319677A PL184612B1 (pl) 1997-04-25 1997-04-25 Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
PCT/PL1998/000014 WO1998049179A2 (en) 1997-04-25 1998-04-23 A process for the synthesis of modified p-chiral nucleotide analogues

Publications (1)

Publication Number Publication Date
ATE270301T1 true ATE270301T1 (de) 2004-07-15

Family

ID=20069747

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98915075T ATE270301T1 (de) 1997-04-25 1998-04-23 Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga

Country Status (8)

Country Link
US (1) US6407223B1 (de)
EP (1) EP0977769B1 (de)
AT (1) ATE270301T1 (de)
AU (1) AU6934398A (de)
DE (1) DE69824843T2 (de)
ES (1) ES2224373T3 (de)
PL (1) PL184612B1 (de)
WO (1) WO1998049179A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077002A2 (en) * 2001-03-22 2002-10-03 Research Foundation Of The City University Of New York Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
PL216525B1 (pl) * 2006-10-17 2014-04-30 Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk 5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
AU2010270714B2 (en) 2009-07-06 2015-08-13 Wave Life Sciences Ltd. Novel nucleic acid prodrugs and methods use thereof
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
DK2734208T3 (en) 2011-07-19 2017-06-19 Wave Life Sciences Ltd PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
US20150157655A1 (en) * 2012-06-29 2015-06-11 Sena Research, Inc. Selenium containing nucleosides as nutritional supplements
US9598458B2 (en) 2012-07-13 2017-03-21 Wave Life Sciences Japan, Inc. Asymmetric auxiliary group
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
SG11201500232UA (en) 2012-07-13 2015-04-29 Wave Life Sciences Pte Ltd Chiral control
EP3095460A4 (de) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chirales nukleinsäureadjuvans mit antiallergischer wirkung und antiallergikum
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10160969B2 (en) 2014-01-16 2018-12-25 Wave Life Sciences Ltd. Chiral design

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852188A (en) * 1990-01-11 1998-12-22 Isis Pharmaceuticals, Inc. Oligonucleotides having chiral phosphorus linkages
US5635488A (en) * 1991-10-15 1997-06-03 Isis Pharmaceuticals, Inc. Compounds having phosphorodithioate linkages of high chiral purity
US5359052A (en) * 1991-08-05 1994-10-25 Polish Academy Of Sciences Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
US5661134A (en) * 1991-10-15 1997-08-26 Isis Pharmaceuticals, Inc. Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
US5599797A (en) * 1991-10-15 1997-02-04 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
US5955597A (en) * 1993-11-16 1999-09-21 Genta, Incorporated Chirally enriched synthetic phosphate oligomers
US5703223A (en) * 1994-09-02 1997-12-30 Thomas Jefferson University Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
DE69629112T2 (de) * 1995-05-26 2004-04-22 Genta Inc., San Diego Verfahren zur synthese von phosphororganischen verbindungen
US5734041A (en) * 1995-10-20 1998-03-31 Mcgill University Preparation of chiral phosphorothioate oligomers
CA2205218C (en) * 1995-10-20 1999-05-25 Hybridon, Inc. Improved methods for h-phosphonate synthesis of mono- and oligonucleotides
US5856465A (en) * 1996-05-24 1999-01-05 Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
AU4089397A (en) * 1996-08-26 1998-03-19 Hybridon, Inc. Improved reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages

Also Published As

Publication number Publication date
EP0977769B1 (de) 2004-06-30
PL319677A1 (en) 1998-10-26
EP0977769A2 (de) 2000-02-09
WO1998049179A3 (en) 1999-03-18
US6407223B1 (en) 2002-06-18
DE69824843T2 (de) 2005-07-21
PL184612B1 (pl) 2002-11-29
ES2224373T3 (es) 2005-03-01
WO1998049179A2 (en) 1998-11-05
AU6934398A (en) 1998-11-24
DE69824843D1 (de) 2004-08-05

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