ATE267394T1 - Nachweis der krankheitsbedingten konformation eines proteins - Google Patents
Nachweis der krankheitsbedingten konformation eines proteinsInfo
- Publication number
- ATE267394T1 ATE267394T1 AT98906471T AT98906471T ATE267394T1 AT E267394 T1 ATE267394 T1 AT E267394T1 AT 98906471 T AT98906471 T AT 98906471T AT 98906471 T AT98906471 T AT 98906471T AT E267394 T1 ATE267394 T1 AT E267394T1
- Authority
- AT
- Austria
- Prior art keywords
- prp
- conformation
- protein
- concentration
- binding partner
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000001514 detection method Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2872—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
- A01K2267/0343—Animal model for prion disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/804,536 US5891641A (en) | 1997-02-21 | 1997-02-21 | Assay for disease related conformation of a protein |
PCT/US1998/002992 WO1998037411A1 (en) | 1997-02-21 | 1998-02-20 | Assay for disease related conformation of a protein |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE267394T1 true ATE267394T1 (de) | 2004-06-15 |
Family
ID=25189206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98906471T ATE267394T1 (de) | 1997-02-21 | 1998-02-20 | Nachweis der krankheitsbedingten konformation eines proteins |
Country Status (10)
Country | Link |
---|---|
US (1) | US5891641A (de) |
EP (2) | EP1416281A3 (de) |
JP (1) | JP3774236B2 (de) |
AT (1) | ATE267394T1 (de) |
AU (1) | AU725844B2 (de) |
BR (1) | BR9807600A (de) |
CA (1) | CA2278577A1 (de) |
DE (2) | DE970372T1 (de) |
ES (1) | ES2218807T3 (de) |
WO (1) | WO1998037411A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6719988B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Antiseptic compositions for inactivating prions |
US6620629B1 (en) * | 1997-02-21 | 2003-09-16 | The Regents Of The University Of California | Method for detecting prions |
US6221614B1 (en) | 1997-02-21 | 2001-04-24 | The Regents Of The University Of California | Removal of prions from blood, plasma and other liquids |
US6617119B2 (en) | 1997-02-21 | 2003-09-09 | The Regents Of The University Of California | Assay for specific strains of multiple disease related conformations of a protein |
US6720355B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Sodium dodecyl sulfate compositions for inactivating prions |
BR9908059A (pt) * | 1998-02-20 | 2002-01-08 | Univ California | Método de análise para espécies especìficas de conformações de uma proteìna relacionadas a várias doenças |
US6127130A (en) | 1998-03-13 | 2000-10-03 | The United States Of America As Represented By The Secretary Of The Navy | Multiassay method for determining the concentrations of antigens and interferants |
GB2362385B (en) * | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Non-aggregated ß-forms of prion proteins |
GB2371049B (en) * | 1998-11-04 | 2003-06-04 | Imp College Innovations Ltd | Methods of making antibodies against ß-forms of prion proteins and their uses |
GB2348203B (en) | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Solube beta-forms of prion proteins, methods of preparation and use |
US6821738B2 (en) * | 1999-01-20 | 2004-11-23 | The Board Of Regents For Oklahoma State University | Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents |
US6605445B1 (en) * | 1999-02-22 | 2003-08-12 | Bayer Corporation | Rapid method of determining clearance of prion protein |
GB9904395D0 (en) * | 1999-02-25 | 1999-04-21 | Fluorescience Ltd | Protein assay |
US6972198B2 (en) * | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
US6166187A (en) * | 1999-03-05 | 2000-12-26 | The Regents Of The University Of California | Method of concentrating prion proteins in blood samples |
GB9908059D0 (en) * | 1999-04-09 | 1999-06-02 | Imp College Innovations Ltd | Diagnosis and treatment of diseases |
DE19918141A1 (de) * | 1999-04-21 | 2000-10-26 | Boehringer Ingelheim Vetmed | Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien |
NZ516240A (en) * | 1999-06-23 | 2005-11-25 | Caprion Pharmaceuticals Inc | Prion protein peptides and uses thereof |
US7041807B1 (en) | 1999-06-23 | 2006-05-09 | Caprion Pharmaceuticals, Inc. | Antibodies to a YYX epitope of a mammalian prion protein |
US6537548B1 (en) | 2000-07-27 | 2003-03-25 | The Regents Of The University Of California | Antibodies specific for ungulate PrP |
JP2004535387A (ja) * | 2001-05-01 | 2004-11-25 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | プリオンの増殖を消失させ、感染性の除去を促進する抗体 |
US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
JP4235544B2 (ja) | 2001-05-31 | 2009-03-11 | アドライフ インコーポレーティッド | 欠陥折畳み蛋白質センサー方法 |
US20030050517A1 (en) * | 2001-07-31 | 2003-03-13 | Ahting Herbert C. | Process for producing glycerin |
JP2005504289A (ja) * | 2001-09-20 | 2005-02-10 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | プリオンアッセイ用に調製された筋肉試料 |
US7803315B2 (en) * | 2001-10-05 | 2010-09-28 | American Sterilizer Company | Decontamination of surfaces contaminated with prion-infected material with gaseous oxidizing agents |
DE10152677A1 (de) * | 2001-10-19 | 2003-05-08 | Aventis Behring Gmbh | Antikörper zum spezifischen Nachweis von pathogenen Prionen humanen Ursprungs und damit durchgeführten Nachweisverfahren |
US20030092090A1 (en) * | 2001-11-14 | 2003-05-15 | Kiamars Hajizadeh | Rapid prion-detection device, system, and test kit |
US7045297B2 (en) * | 2001-11-14 | 2006-05-16 | Prion Developmental Laboratories, Inc. | Rapid prion-detection assay |
NZ536054A (en) * | 2002-04-09 | 2009-10-30 | Scripps Research Inst | Motif-grafted hybrid polypeptides and uses thereof |
US20040072236A1 (en) | 2002-09-27 | 2004-04-15 | Neil Cashman | PrPSc -interacting molecules and uses thereof |
FR2849205B1 (fr) * | 2002-12-20 | 2005-02-11 | Afssa | Procede d'amplification de la detection de la prpsc et utilisation d'un ligand adjuvant macrocyclique pour une telle amplification |
US20040192887A1 (en) * | 2003-03-25 | 2004-09-30 | Ralph Zahn | PH-dependent polypeptide aggregation and its use |
US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US20050256425A1 (en) | 2004-05-11 | 2005-11-17 | Inpro Biotechnology, Inc. | Device, system and method for extracting and preparing brain tissue |
US9488655B2 (en) * | 2004-07-14 | 2016-11-08 | The Regents Of The University Of California | Biomarkers for detection of early- and late-stage endometrial cancer |
US9487575B2 (en) | 2004-07-14 | 2016-11-08 | The Regents Of The University Of California | Compositions and methods for treatment of gynecologic cancers |
EP2199801B1 (de) * | 2004-07-14 | 2013-05-29 | The Regents of The University of California | Biomarker zur Früherkennung von Eierstockkrebs |
WO2006036410A2 (en) * | 2004-08-27 | 2006-04-06 | The Regents Of The University Of California | Protection from and treatment of prion protein infection |
JP5162250B2 (ja) * | 2005-01-13 | 2013-03-13 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | プリオン特異的ペプチド試薬を使用するelisaアッセイ |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
WO2006088823A2 (en) * | 2005-02-15 | 2006-08-24 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
WO2006102099A2 (en) * | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP |
JP4724816B2 (ja) * | 2005-09-06 | 2011-07-13 | シャープ株式会社 | タンパク質の測定方法 |
US20070196863A1 (en) * | 2006-02-17 | 2007-08-23 | Hanson Technologies, Inc. | Prion protein detection |
WO2008013859A2 (en) * | 2006-07-28 | 2008-01-31 | Adlyfe, Inc. | Peptide probes for diagnostics and therapeutics |
US20110189692A1 (en) * | 2008-04-30 | 2011-08-04 | Novartis Ag | Assay for pathogenic conformers |
KR20140063747A (ko) | 2011-08-29 | 2014-05-27 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 전염증성 상태를 치료 및 예방하기 위한 hdl-관련 분자의 용도 |
CN104781271B (zh) | 2012-08-20 | 2018-07-06 | 加利福尼亚大学董事会 | 具有生物可逆的基团的多核苷酸 |
JP7178607B2 (ja) * | 2018-02-23 | 2022-11-28 | 学校法人麻布獣医学園 | アミロイドタンパク質を抽出する試薬 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806627A (en) * | 1987-05-29 | 1989-02-21 | Research Foundation Of Mental Hygiene Inc. | Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins |
ES2237747T3 (es) * | 1991-11-14 | 2005-08-01 | Prionics Ag | Animales transgenicos no humanos que carecen de proteinas prionicas. |
AU4376093A (en) * | 1992-05-15 | 1993-12-13 | Instituto Nazionale Neurologico C. Besta | Soluble prion polypeptides, and methods for detecting and purifying thereof |
US5565186A (en) * | 1994-05-13 | 1996-10-15 | The Regents Of The University Of California | Method of detecting prions in a sample and transgenic animal used for same |
US5750361A (en) * | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
EP0914614B1 (de) * | 1996-05-14 | 2003-09-03 | Winnacker, Ernst-Ludwig, Prof. | Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können |
EP0861900A1 (de) * | 1997-02-21 | 1998-09-02 | Erziehungsdirektion Of The Canton Zurich | Immunologischer Nachweis von Prionen |
-
1997
- 1997-02-21 US US08/804,536 patent/US5891641A/en not_active Expired - Fee Related
-
1998
- 1998-02-20 JP JP53606498A patent/JP3774236B2/ja not_active Expired - Fee Related
- 1998-02-20 BR BR9807600-0A patent/BR9807600A/pt not_active Application Discontinuation
- 1998-02-20 DE DE0970372T patent/DE970372T1/de active Pending
- 1998-02-20 EP EP04000945A patent/EP1416281A3/de not_active Withdrawn
- 1998-02-20 WO PCT/US1998/002992 patent/WO1998037411A1/en active IP Right Grant
- 1998-02-20 CA CA002278577A patent/CA2278577A1/en not_active Abandoned
- 1998-02-20 AT AT98906471T patent/ATE267394T1/de not_active IP Right Cessation
- 1998-02-20 ES ES98906471T patent/ES2218807T3/es not_active Expired - Lifetime
- 1998-02-20 EP EP98906471A patent/EP0970372B1/de not_active Expired - Lifetime
- 1998-02-20 AU AU61688/98A patent/AU725844B2/en not_active Ceased
- 1998-02-20 DE DE69823985T patent/DE69823985T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2278577A1 (en) | 1998-08-27 |
EP1416281A3 (de) | 2004-05-19 |
EP0970372A4 (de) | 2002-04-10 |
AU6168898A (en) | 1998-09-09 |
ES2218807T3 (es) | 2004-11-16 |
JP2001516448A (ja) | 2001-09-25 |
JP3774236B2 (ja) | 2006-05-10 |
DE69823985T2 (de) | 2005-07-21 |
WO1998037411A1 (en) | 1998-08-27 |
EP0970372A1 (de) | 2000-01-12 |
DE69823985D1 (de) | 2004-06-24 |
AU725844B2 (en) | 2000-10-19 |
DE970372T1 (de) | 2001-10-25 |
US5891641A (en) | 1999-04-06 |
EP1416281A2 (de) | 2004-05-06 |
EP0970372B1 (de) | 2004-05-19 |
BR9807600A (pt) | 2000-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |