BR9807600A - Método para determinar a presença de uma forma patogênica de uma proteìna selecionada numa amostra - Google Patents
Método para determinar a presença de uma forma patogênica de uma proteìna selecionada numa amostraInfo
- Publication number
- BR9807600A BR9807600A BR9807600-0A BR9807600A BR9807600A BR 9807600 A BR9807600 A BR 9807600A BR 9807600 A BR9807600 A BR 9807600A BR 9807600 A BR9807600 A BR 9807600A
- Authority
- BR
- Brazil
- Prior art keywords
- prp
- conformation
- sample
- concentration
- determining
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000001717 pathogenic effect Effects 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2872—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
- A01K2267/0343—Animal model for prion disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Abstract
<B>MéTODO PARA DETERMINAR A PRESENçA DE UMA FORMA PATOGêNICA DE UMA PROTEìNA SELECIONADA NUMA AMOSTRA"<D>. Um método de ensaio é revelado que torna possível determinar a presença de conformação, relacionada com doença, de uma proteína (por exemplo, PrP^ Sc^ ou a forma de folha <225> de uma <225>A4) em uma amostra. Uma amostra é dividida em duas porções e a primeira porção é presa transversalmente a um primeiro apoio sólido e então contactada com um anticorpo rotulado que se aglutina a uma forma de não-doença da proteína com um grau mais elevado de afinidade (por exemplo, 4 para 30 vezes mais elevada) que a forma de doença da proteína, para mudar a conformação em uma forma com uma afinidade aglutinadora mais elevada para anticorpo rotulado. A segunda porção tratada é então aglutinada a um segundo apoio sólido e contactada com anticorpo rotulado. O nível do anticorpo rotulado que se aglutina a uma proteína nas primeira e segunda porção é determinado e as quantidades medidas em cada uma delas são comparadas. A diferença entre as duas medições é uma indicação de se a conformação relacionada com doença da proteína estava presente na amostra. O método pode também determinar a concentração da conformação relacionada com a doença e a cepa particular presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/804,536 US5891641A (en) | 1997-02-21 | 1997-02-21 | Assay for disease related conformation of a protein |
PCT/US1998/002992 WO1998037411A1 (en) | 1997-02-21 | 1998-02-20 | Assay for disease related conformation of a protein |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9807600A true BR9807600A (pt) | 2000-02-22 |
Family
ID=25189206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9807600-0A BR9807600A (pt) | 1997-02-21 | 1998-02-20 | Método para determinar a presença de uma forma patogênica de uma proteìna selecionada numa amostra |
Country Status (10)
Country | Link |
---|---|
US (1) | US5891641A (pt) |
EP (2) | EP0970372B1 (pt) |
JP (1) | JP3774236B2 (pt) |
AT (1) | ATE267394T1 (pt) |
AU (1) | AU725844B2 (pt) |
BR (1) | BR9807600A (pt) |
CA (1) | CA2278577A1 (pt) |
DE (2) | DE69823985T2 (pt) |
ES (1) | ES2218807T3 (pt) |
WO (1) | WO1998037411A1 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6720355B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Sodium dodecyl sulfate compositions for inactivating prions |
US6719988B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Antiseptic compositions for inactivating prions |
US6221614B1 (en) * | 1997-02-21 | 2001-04-24 | The Regents Of The University Of California | Removal of prions from blood, plasma and other liquids |
US6620629B1 (en) * | 1997-02-21 | 2003-09-16 | The Regents Of The University Of California | Method for detecting prions |
US6617119B2 (en) | 1997-02-21 | 2003-09-09 | The Regents Of The University Of California | Assay for specific strains of multiple disease related conformations of a protein |
DE1057022T1 (de) * | 1998-02-20 | 2001-10-25 | The Regents Of The University Of California, Oakland | Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen |
US6127130A (en) * | 1998-03-13 | 2000-10-03 | The United States Of America As Represented By The Secretary Of The Navy | Multiassay method for determining the concentrations of antigens and interferants |
GB2362385B (en) * | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Non-aggregated ß-forms of prion proteins |
GB2348203B (en) | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Solube beta-forms of prion proteins, methods of preparation and use |
GB2371049B (en) * | 1998-11-04 | 2003-06-04 | Imp College Innovations Ltd | Methods of making antibodies against ß-forms of prion proteins and their uses |
US6821738B2 (en) * | 1999-01-20 | 2004-11-23 | The Board Of Regents For Oklahoma State University | Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents |
US6605445B1 (en) * | 1999-02-22 | 2003-08-12 | Bayer Corporation | Rapid method of determining clearance of prion protein |
GB9904395D0 (en) * | 1999-02-25 | 1999-04-21 | Fluorescience Ltd | Protein assay |
US6972198B2 (en) * | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
US6166187A (en) * | 1999-03-05 | 2000-12-26 | The Regents Of The University Of California | Method of concentrating prion proteins in blood samples |
GB9908059D0 (en) | 1999-04-09 | 1999-06-02 | Imp College Innovations Ltd | Diagnosis and treatment of diseases |
DE19918141A1 (de) * | 1999-04-21 | 2000-10-26 | Boehringer Ingelheim Vetmed | Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien |
DE60032486T2 (de) * | 1999-06-23 | 2007-08-16 | Idexx Laboratories, Inc. | Prion protein peptide und deren verwendung |
US7041807B1 (en) | 1999-06-23 | 2006-05-09 | Caprion Pharmaceuticals, Inc. | Antibodies to a YYX epitope of a mammalian prion protein |
US6537548B1 (en) | 2000-07-27 | 2003-03-25 | The Regents Of The University Of California | Antibodies specific for ungulate PrP |
JP2004535387A (ja) * | 2001-05-01 | 2004-11-25 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | プリオンの増殖を消失させ、感染性の除去を促進する抗体 |
US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
US7166471B2 (en) | 2001-05-31 | 2007-01-23 | Arete Associates | Misfolded protein sensor method in body fluids |
US20030050517A1 (en) * | 2001-07-31 | 2003-03-13 | Ahting Herbert C. | Process for producing glycerin |
EP1436618A4 (en) * | 2001-09-20 | 2006-02-08 | Univ California | MUSCLE SAMPLE PREPARED FOR PRION DETECTION TEST |
US7803315B2 (en) * | 2001-10-05 | 2010-09-28 | American Sterilizer Company | Decontamination of surfaces contaminated with prion-infected material with gaseous oxidizing agents |
DE10152677A1 (de) * | 2001-10-19 | 2003-05-08 | Aventis Behring Gmbh | Antikörper zum spezifischen Nachweis von pathogenen Prionen humanen Ursprungs und damit durchgeführten Nachweisverfahren |
US20030092090A1 (en) * | 2001-11-14 | 2003-05-15 | Kiamars Hajizadeh | Rapid prion-detection device, system, and test kit |
US7045297B2 (en) * | 2001-11-14 | 2006-05-16 | Prion Developmental Laboratories, Inc. | Rapid prion-detection assay |
CA2481437A1 (en) * | 2002-04-09 | 2003-10-16 | The Scripps Research Institute | Motif-grafted hybrid polypeptides and uses thereof |
US20040072236A1 (en) | 2002-09-27 | 2004-04-15 | Neil Cashman | PrPSc -interacting molecules and uses thereof |
FR2849205B1 (fr) * | 2002-12-20 | 2005-02-11 | Afssa | Procede d'amplification de la detection de la prpsc et utilisation d'un ligand adjuvant macrocyclique pour une telle amplification |
US20040192887A1 (en) * | 2003-03-25 | 2004-09-30 | Ralph Zahn | PH-dependent polypeptide aggregation and its use |
US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US20050256425A1 (en) | 2004-05-11 | 2005-11-17 | Inpro Biotechnology, Inc. | Device, system and method for extracting and preparing brain tissue |
US9487575B2 (en) | 2004-07-14 | 2016-11-08 | The Regents Of The University Of California | Compositions and methods for treatment of gynecologic cancers |
US9488655B2 (en) * | 2004-07-14 | 2016-11-08 | The Regents Of The University Of California | Biomarkers for detection of early- and late-stage endometrial cancer |
ATE481645T1 (de) * | 2004-07-14 | 2010-10-15 | Univ California | Biomarker für den frühzeitigen nachweis von ovarialkarzinom |
WO2006036410A2 (en) * | 2004-08-27 | 2006-04-06 | The Regents Of The University Of California | Protection from and treatment of prion protein infection |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
WO2006076687A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Elisa assays using prion-specific peptide reagents |
US8372593B2 (en) * | 2005-02-15 | 2013-02-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
WO2006102099A2 (en) * | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP |
JP4724816B2 (ja) * | 2005-09-06 | 2011-07-13 | シャープ株式会社 | タンパク質の測定方法 |
US20070196863A1 (en) * | 2006-02-17 | 2007-08-23 | Hanson Technologies, Inc. | Prion protein detection |
JP5097206B2 (ja) * | 2006-07-28 | 2012-12-12 | エイディーライフ インコーポレイティッド | 診断および治療のためのペプチドプローブ |
AU2009243060A1 (en) * | 2008-04-30 | 2009-11-05 | Novartis Ag. | Assay for pathogenic conformers |
EP2751126B1 (en) | 2011-08-29 | 2018-03-07 | The Regents of The University of California | Use of hdl-related molecules to treat and prevent proinflammatory conditions |
CA2880869A1 (en) | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
JP7178607B2 (ja) * | 2018-02-23 | 2022-11-28 | 学校法人麻布獣医学園 | アミロイドタンパク質を抽出する試薬 |
US20240199857A1 (en) * | 2022-12-16 | 2024-06-20 | The Chinese University Of Hong Kong | Chaotropes-assisted deep immunostaining |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806627A (en) * | 1987-05-29 | 1989-02-21 | Research Foundation Of Mental Hygiene Inc. | Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins |
SG47979A1 (en) * | 1991-11-14 | 1998-04-17 | Charles Weissman | Transgenic animals lacking prion proteins |
WO1993023432A1 (en) * | 1992-05-15 | 1993-11-25 | New York University | Soluble prion polypeptides, and methods for detecting and purifying thereof |
US5565186A (en) * | 1994-05-13 | 1996-10-15 | The Regents Of The University Of California | Method of detecting prions in a sample and transgenic animal used for same |
US5750361A (en) * | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
DE69724619T2 (de) * | 1996-05-14 | 2004-07-01 | Winnacker, Ernst-Ludwig, Prof. | Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können |
EP0861900A1 (en) * | 1997-02-21 | 1998-09-02 | Erziehungsdirektion Of The Canton Zurich | Immunological detection of prions |
-
1997
- 1997-02-21 US US08/804,536 patent/US5891641A/en not_active Expired - Fee Related
-
1998
- 1998-02-20 EP EP98906471A patent/EP0970372B1/en not_active Expired - Lifetime
- 1998-02-20 BR BR9807600-0A patent/BR9807600A/pt not_active Application Discontinuation
- 1998-02-20 WO PCT/US1998/002992 patent/WO1998037411A1/en active IP Right Grant
- 1998-02-20 DE DE69823985T patent/DE69823985T2/de not_active Expired - Fee Related
- 1998-02-20 EP EP04000945A patent/EP1416281A3/en not_active Withdrawn
- 1998-02-20 AU AU61688/98A patent/AU725844B2/en not_active Ceased
- 1998-02-20 DE DE0970372T patent/DE970372T1/de active Pending
- 1998-02-20 AT AT98906471T patent/ATE267394T1/de not_active IP Right Cessation
- 1998-02-20 JP JP53606498A patent/JP3774236B2/ja not_active Expired - Fee Related
- 1998-02-20 ES ES98906471T patent/ES2218807T3/es not_active Expired - Lifetime
- 1998-02-20 CA CA002278577A patent/CA2278577A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1998037411A1 (en) | 1998-08-27 |
US5891641A (en) | 1999-04-06 |
EP0970372A1 (en) | 2000-01-12 |
EP1416281A3 (en) | 2004-05-19 |
JP3774236B2 (ja) | 2006-05-10 |
EP1416281A2 (en) | 2004-05-06 |
EP0970372B1 (en) | 2004-05-19 |
ES2218807T3 (es) | 2004-11-16 |
CA2278577A1 (en) | 1998-08-27 |
DE69823985T2 (de) | 2005-07-21 |
ATE267394T1 (de) | 2004-06-15 |
JP2001516448A (ja) | 2001-09-25 |
AU725844B2 (en) | 2000-10-19 |
AU6168898A (en) | 1998-09-09 |
DE970372T1 (de) | 2001-10-25 |
EP0970372A4 (en) | 2002-04-10 |
DE69823985D1 (de) | 2004-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
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