ATE266627T1 - Nitril synthese an fester phase - Google Patents

Nitril synthese an fester phase

Info

Publication number
ATE266627T1
ATE266627T1 AT00946121T AT00946121T ATE266627T1 AT E266627 T1 ATE266627 T1 AT E266627T1 AT 00946121 T AT00946121 T AT 00946121T AT 00946121 T AT00946121 T AT 00946121T AT E266627 T1 ATE266627 T1 AT E266627T1
Authority
AT
Austria
Prior art keywords
solid phase
nitrile synthesis
nitrile
amide
synthesis
Prior art date
Application number
AT00946121T
Other languages
English (en)
Inventor
Ryszard Kobylecki
David Neal Hone
Lloyd James Payne
Original Assignee
Millennium Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Ltd filed Critical Millennium Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE266627T1 publication Critical patent/ATE266627T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00946121T 1999-07-15 2000-07-17 Nitril synthese an fester phase ATE266627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9916575.5A GB9916575D0 (en) 1999-07-15 1999-07-15 Solid phase nitrile synthesis
PCT/GB2000/002740 WO2001005747A1 (en) 1999-07-15 2000-07-17 Solid phase nitrile synthesis

Publications (1)

Publication Number Publication Date
ATE266627T1 true ATE266627T1 (de) 2004-05-15

Family

ID=10857267

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946121T ATE266627T1 (de) 1999-07-15 2000-07-17 Nitril synthese an fester phase

Country Status (6)

Country Link
US (1) US6664410B1 (de)
EP (1) EP1196375B1 (de)
AT (1) ATE266627T1 (de)
DE (1) DE60010705T2 (de)
GB (1) GB9916575D0 (de)
WO (1) WO2001005747A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3599390B2 (ja) * 1994-11-04 2004-12-08 日本メクトロン株式会社 パーフルオロ不飽和ニトリル化合物およびその製造法
US5767238A (en) * 1995-06-07 1998-06-16 Combichem, Inc. Inverse solid phase synthesis
US6392010B1 (en) * 1996-12-19 2002-05-21 Aventis Pharmaceuticals Inc. Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
US6462076B2 (en) * 2000-06-14 2002-10-08 Hoffmann-La Roche Inc. Beta-amino acid nitrile derivatives as cathepsin K inhibitors

Also Published As

Publication number Publication date
US6664410B1 (en) 2003-12-16
DE60010705D1 (en) 2004-06-17
GB9916575D0 (en) 1999-09-15
WO2001005747A1 (en) 2001-01-25
EP1196375B1 (de) 2004-05-12
DE60010705T2 (de) 2005-05-19
EP1196375A1 (de) 2002-04-17

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