ATE260673T1 - Cyclosporin-emulsionen - Google Patents

Cyclosporin-emulsionen

Info

Publication number
ATE260673T1
ATE260673T1 AT97302298T AT97302298T ATE260673T1 AT E260673 T1 ATE260673 T1 AT E260673T1 AT 97302298 T AT97302298 T AT 97302298T AT 97302298 T AT97302298 T AT 97302298T AT E260673 T1 ATE260673 T1 AT E260673T1
Authority
AT
Austria
Prior art keywords
oil
cyclosporine
emulsions
cyclosporine emulsions
phospholipid
Prior art date
Application number
AT97302298T
Other languages
English (en)
Inventor
Indu Parikh
Awadhesh Mishra
Original Assignee
Rtp Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rtp Pharma Corp filed Critical Rtp Pharma Corp
Application granted granted Critical
Publication of ATE260673T1 publication Critical patent/ATE260673T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT97302298T 1996-04-03 1997-04-03 Cyclosporin-emulsionen ATE260673T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/627,187 US5660858A (en) 1996-04-03 1996-04-03 Cyclosporin emulsions

Publications (1)

Publication Number Publication Date
ATE260673T1 true ATE260673T1 (de) 2004-03-15

Family

ID=24513586

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97302298T ATE260673T1 (de) 1996-04-03 1997-04-03 Cyclosporin-emulsionen

Country Status (9)

Country Link
US (1) US5660858A (de)
EP (1) EP0799620B1 (de)
JP (1) JP4212113B2 (de)
AT (1) ATE260673T1 (de)
AU (1) AU2588597A (de)
CA (1) CA2250970C (de)
DE (1) DE69727849T2 (de)
ES (1) ES2217368T3 (de)
WO (1) WO1997036611A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19537012A1 (de) * 1995-10-04 1997-04-10 Dietl Hans Cyclosporin(e) enhaltende pharmazeutische Zubereitung zur oralen Applikation und Verfahren zu ihrer Herstellung
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) * 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6281175B1 (en) 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
US6054421A (en) * 1997-09-23 2000-04-25 Scimed Life Systems, Inc. Medical emulsion lubricant
DE19810655A1 (de) * 1998-03-12 1999-09-16 Univ Eberhard Karls Arzneimittel mit einem Gehalt an Ciclosporin
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
JP2002516267A (ja) 1998-05-29 2002-06-04 アールティーピー・ファーマ・インコーポレーテッド 熱的に保護された微粒子組成物及びその最終蒸気滅菌
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
EP1105096B1 (de) 1998-08-19 2003-10-29 Skyepharma Canada Inc. Injizierbare wässerige propofoldispersionen
US7939105B2 (en) 1998-11-20 2011-05-10 Jagotec Ag Process for preparing a rapidly dispersing solid drug dosage form
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
EP1408930A1 (de) * 1999-10-20 2004-04-21 Vesifact Ag Cyclosporine enthaltende mikroemulsion-prekonzentrate und mikroemulsionen
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
DE19961733A1 (de) * 1999-12-21 2001-06-28 Ciclomulsion Ag Cyclosporin(e) enthaltende hypertone pharmazeutische Zubereitung zur Anwendung bei neurologischen Erkrankungen und als Neuroprotektivum sowie Verfahren zu ihrer Herstellung
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10030378A1 (de) * 2000-06-21 2002-03-14 Audit Inst For Medical Service Neue pharmazeutische Zusammensetzung zur topischen Anwendung von wasserunlöslichen und/oder schwer wasserlöslichen Wirkstoffen
DE10036871A1 (de) * 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6607784B2 (en) * 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
WO2003026611A2 (en) 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
DE60233150D1 (de) * 2001-10-19 2009-09-10 Isotechnika Inc Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
RU2301679C2 (ru) * 2001-12-14 2007-06-27 Яготек Аг Фармацевтический препарат, содержащий циклоспорин, и его применение
AU2002231703B2 (en) * 2001-12-14 2007-03-29 Jagotec Ag Pharmaceutical formulation comprising cyclosporin and use thereof
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
DE10347994A1 (de) 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
EP1711163A2 (de) * 2004-02-05 2006-10-18 Baxter International Inc. Unter verwendung von selbststabilisierenden mitteln hergestellte dispersionen
US8557861B2 (en) 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
DE102006051512A1 (de) 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
US11311477B2 (en) * 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
DE602007009377D1 (de) 2006-05-30 2010-11-04 Intarcia Therapeutics Inc Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem
EP2359808B1 (de) 2006-08-09 2013-05-22 Intarcia Therapeutics, Inc Osmotisches Verabreichungssystem mit Kolbenanordnung
BRPI0719756A2 (pt) * 2006-12-01 2014-01-21 Anterios Inc Nanopartículas de entidades anfifílicas
AU2007353340A1 (en) * 2006-12-01 2008-11-20 Anterios, Inc. Peptide nanoparticles and uses therefor
US10265265B2 (en) * 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
US20080234232A1 (en) * 2007-03-20 2008-09-25 Flynn Daniel C Methods and compositions for targeting AFAP
JP5135852B2 (ja) 2007-03-30 2013-02-06 日油株式会社 可溶化用組成物
CN104000779A (zh) 2007-04-23 2014-08-27 精达制药公司 促胰岛素释放肽的混悬制剂及其应用
TW200904485A (en) * 2007-05-18 2009-02-01 Alcon Res Ltd Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
WO2008151022A2 (en) 2007-05-31 2008-12-11 Anterios, Inc. Nucleic acid nanoparticles and uses therefor
EP2008651A1 (de) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited Biologisch erodierbares Patch
MX340897B (es) * 2007-10-02 2016-07-29 Theranos Inc Dispositivos modulares de punto de cuidado y usos de los mismos.
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
JP2012514644A (ja) * 2009-01-08 2012-06-28 アラーガン インコーポレイテッド 爪成長の増進用シクロスポリン組成物
NO2462246T3 (de) 2009-09-28 2018-02-03
CN106236708B (zh) 2009-11-17 2020-06-26 迈克尔·A·福兰 含游离脂肪酸的抗微生物组合物
JP2012051823A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 難容性薬物含有水中油型乳化組成物及びその製造方法
WO2012069149A1 (en) * 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012123515A1 (en) 2011-03-14 2012-09-20 Drug Delivery Solutions Limited An ophthalmic composition
KR101492447B1 (ko) 2013-05-20 2015-02-23 주식회사태준제약 사이클로스포린을 함유하는 나노에멀젼 점안 조성물 및 그의 제조 방법
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
TWI754643B (zh) 2016-05-16 2022-02-11 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
KR102487144B1 (ko) 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
WO2018129058A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
EP3542788A1 (de) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topische zusammensetzung enthaltend calcipotriol und betamethason dipropionat

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1165238A (en) * 1980-03-12 1984-04-10 Demetrios P. Papahadjopoulos Activated liposomes and method
EP0327280B1 (de) * 1988-01-29 1992-03-18 Sankyo Company Limited Cyclosporin-Zusammensetzungen
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US5338761A (en) * 1988-09-29 1994-08-16 Shiseido Company Ltd. Emulsified composition
CA2013755C (en) * 1989-04-05 1993-11-30 Simon Benita Medicinal emulsions
JP2785981B2 (ja) * 1989-11-20 1998-08-13 株式会社資生堂 乳化組成物
DE59310166D1 (de) * 1992-05-18 2001-05-31 Ciclomulsion Ag Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur intravenösen Applikation sowie Verfahren zu ihrer Herstellung
US5529785A (en) * 1993-05-12 1996-06-25 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
EP0671929A4 (de) * 1992-10-16 1996-09-25 Smithkline Beecham Corp Zusammensetzungen.
EP0666752A4 (de) * 1992-10-16 1996-09-11 Smithkline Beecham Corp Therapeutische mikroemulsionen.
DE4338086A1 (de) * 1993-11-08 1995-05-11 Dietl Hans Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur oralen Applikation sowie Verfahren zu ihrer Herstellung
GB9601120D0 (en) * 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
EP0799620A1 (de) 1997-10-08
DE69727849D1 (de) 2004-04-08
AU2588597A (en) 1997-10-22
WO1997036611A1 (en) 1997-10-09
ES2217368T3 (es) 2004-11-01
DE69727849T2 (de) 2004-07-29
CA2250970C (en) 2012-10-16
US5660858A (en) 1997-08-26
JP2000509021A (ja) 2000-07-18
EP0799620B1 (de) 2004-03-03
CA2250970A1 (en) 1997-10-09
JP4212113B2 (ja) 2009-01-21

Similar Documents

Publication Publication Date Title
ATE260673T1 (de) Cyclosporin-emulsionen
ES2094031T3 (es) Emulsion de aceite en agua utilizable para la obtencion de una crema.
DK1044678T3 (da) Tårekirtelspecifikke emulsioner til topisk anvendelse til okulært væv
ATE497384T1 (de) Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen
ES2043279T3 (es) Emulsion comestible de aceite en agua.
DE60131862D1 (de) Herstellung von vitaminemulsionen und konzentrate davon
ATE66366T1 (de) Kortikoidhaltige zubereitung zur topischen applikation.
ATE283031T1 (de) Nichtirritierende kosmetische und pharmazeutische zusammensetzungen
DE50013111D1 (de) Kosmetische und dermatologische Zubereitungen auf der Grundlage von O/W-Emulsionen
NO308448B1 (no) Mikrosfærer samt fremstilling, preparater og anvendelse derav
RU2000112410A (ru) Стабильные косметические композиции
KR840003028A (ko) 종양치료제의 오일상 조성물의 제조방법
ATE270537T1 (de) Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut
ATE331498T1 (de) Kosmetische und dermatologische zubereitungen auf der grundlage von o/w-emulsionen
EP1459801A3 (de) Wasser-in-Öl Emulsionen, insbesondere für Sonnenschutz, und Verfahren zu deren Herstellung
ES2179008T3 (es) Composicion en forma de emulsion de aceite-en-agua que contiene fibras, y sus utilizaciones principalmente cosmeticas.
ES2189891T3 (es) Emulsiones de liquidos optimizadas para la hidrolisis y uso de las mismas.
EA200300680A1 (ru) Масло для кожи, содержащее растворимые в масле компоненты
TR199903271T2 (en) Tokoferol ile karl�la�t�r�lan soluma i�in prolipozom tozlar�.
FR2721800B1 (fr) Nouveaux concentres emulsionnables renfermant un u plussieurs pesticides
BR0304135A (pt) Método melhorado para a formação de uma fase estável de emulsão baseada em emulsificante polimérico, e, método para melhorar a capacidade de homogeneização de um explosivo em emulsão
ATE329570T1 (de) Emulsion enthaltend siliconöl- und co- lösungsmittelsystem enhaltend fettlösliche kosmetische wirkstoffe und daraus hergestelleten kosmetischen zubereitungen
KR970005288A (ko) 유용성 감초추출물을 안정화시킨 지질 액정겔 및 이를 함유하는 화장료 조성물
DE50009291D1 (de) Fliessfähige zubereitungen vom emulsionstyp w/o mit erhöhtem wassergehalt mit einem gehalt an mittelpolaren lipiden
EP0648497A4 (de) Emulsionen von aureobasidin.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties