ATE260673T1 - Cyclosporin-emulsionen - Google Patents

Cyclosporin-emulsionen

Info

Publication number
ATE260673T1
ATE260673T1 AT97302298T AT97302298T ATE260673T1 AT E260673 T1 ATE260673 T1 AT E260673T1 AT 97302298 T AT97302298 T AT 97302298T AT 97302298 T AT97302298 T AT 97302298T AT E260673 T1 ATE260673 T1 AT E260673T1
Authority
AT
Austria
Prior art keywords
oil
cyclosporine
emulsions
cyclosporine emulsions
phospholipid
Prior art date
Application number
AT97302298T
Other languages
English (en)
Inventor
Indu Parikh
Awadhesh Mishra
Original Assignee
Rtp Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rtp Pharma Corp filed Critical Rtp Pharma Corp
Application granted granted Critical
Publication of ATE260673T1 publication Critical patent/ATE260673T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT97302298T 1996-04-03 1997-04-03 Cyclosporin-emulsionen ATE260673T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/627,187 US5660858A (en) 1996-04-03 1996-04-03 Cyclosporin emulsions

Publications (1)

Publication Number Publication Date
ATE260673T1 true ATE260673T1 (de) 2004-03-15

Family

ID=24513586

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97302298T ATE260673T1 (de) 1996-04-03 1997-04-03 Cyclosporin-emulsionen

Country Status (9)

Country Link
US (1) US5660858A (de)
EP (1) EP0799620B1 (de)
JP (1) JP4212113B2 (de)
AT (1) ATE260673T1 (de)
AU (1) AU2588597A (de)
CA (1) CA2250970C (de)
DE (1) DE69727849T2 (de)
ES (1) ES2217368T3 (de)
WO (1) WO1997036611A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19537012A1 (de) * 1995-10-04 1997-04-10 Dietl Hans Cyclosporin(e) enhaltende pharmazeutische Zubereitung zur oralen Applikation und Verfahren zu ihrer Herstellung
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) * 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6281175B1 (en) 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
US6054421A (en) * 1997-09-23 2000-04-25 Scimed Life Systems, Inc. Medical emulsion lubricant
DE19810655A1 (de) * 1998-03-12 1999-09-16 Univ Eberhard Karls Arzneimittel mit einem Gehalt an Ciclosporin
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
HK1039458B (zh) 1998-05-29 2006-09-01 Skyepharma Canada Inc. 熱保護微粒組合物及其最終蒸汽滅菌的方法
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
ES2211151T3 (es) 1998-08-19 2004-07-01 Skyepharma Canada Inc. Dispersiones acuosas inyectables de propofol.
SK288117B6 (sk) 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
EP1154759B1 (de) 1998-12-30 2008-08-13 Dexcel Ltd. Dispergierbares konzentrat zur verabreichung von cyclosporin
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
AU7638300A (en) * 1999-10-20 2001-04-30 Vesifact Ag Microemulsion preconcentrates and microemulsions
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
DE19961733A1 (de) * 1999-12-21 2001-06-28 Ciclomulsion Ag Cyclosporin(e) enthaltende hypertone pharmazeutische Zubereitung zur Anwendung bei neurologischen Erkrankungen und als Neuroprotektivum sowie Verfahren zu ihrer Herstellung
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10030378A1 (de) * 2000-06-21 2002-03-14 Audit Inst For Medical Service Neue pharmazeutische Zusammensetzung zur topischen Anwendung von wasserunlöslichen und/oder schwer wasserlöslichen Wirkstoffen
DE10036871A1 (de) * 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US6869617B2 (en) * 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
HRP20040354B1 (en) * 2001-10-19 2012-10-31 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
HUP0402318A3 (en) * 2001-12-14 2012-09-28 Jagotec Ag Pharmaceutical composition comprising cyclosporin and use thereof
RU2301679C2 (ru) * 2001-12-14 2007-06-27 Яготек Аг Фармацевтический препарат, содержащий циклоспорин, и его применение
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
DE10347994A1 (de) 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
JP2007520555A (ja) * 2004-02-05 2007-07-26 バクスター・インターナショナル・インコーポレイテッド 自己安定化剤の使用により調製された分散剤
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
DE102006051512A1 (de) 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
US11311477B2 (en) * 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
MX2008014870A (es) 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.
EP2049081B1 (de) 2006-08-09 2012-11-14 Intarcia Therapeutics, Inc. Osmotische freisetzungssysteme und kolbenanordnungen
WO2008070538A2 (en) * 2006-12-01 2008-06-12 Anterios, Inc. Micellar nanoparticles comprising botulinum toxin
SG10201607909WA (en) * 2006-12-01 2016-11-29 Anterios Inc Peptide nanoparticles and uses therefor
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
US20080234232A1 (en) * 2007-03-20 2008-09-25 Flynn Daniel C Methods and compositions for targeting AFAP
JP5135852B2 (ja) 2007-03-30 2013-02-06 日油株式会社 可溶化用組成物
HRP20130259T1 (hr) 2007-04-23 2013-04-30 Intarcia Therapeutics, Inc. Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe
TW200904485A (en) * 2007-05-18 2009-02-01 Alcon Res Ltd Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
WO2008151022A2 (en) 2007-05-31 2008-12-11 Anterios, Inc. Nucleic acid nanoparticles and uses therefor
EP2008651A1 (de) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited Biologisch erodierbares Patch
MX340897B (es) 2007-10-02 2016-07-29 Theranos Inc Dispositivos modulares de punto de cuidado y usos de los mismos.
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
AU2010203607A1 (en) * 2009-01-08 2011-07-21 Allergan, Inc. Cyclosporine compositions for enhancing nail growth
SMT201700583T1 (it) 2009-09-28 2018-01-11 Intarcia Therapeutics Inc Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
ES2643862T3 (es) * 2009-11-17 2017-11-24 Michael Anthony Folan Composiciones antimicrobianas que contienen ácidos grasos libres
JP2012051823A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 難容性薬物含有水中油型乳化組成物及びその製造方法
WO2012069149A1 (en) * 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9610245B2 (en) 2011-03-14 2017-04-04 Drug Delivery Solutions Limited Ophthalmic composition
KR101492447B1 (ko) 2013-05-20 2015-02-23 주식회사태준제약 사이클로스포린을 함유하는 나노에멀젼 점안 조성물 및 그의 제조 방법
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
AU2017360346B2 (en) 2016-11-21 2023-11-23 Eirion Therapeutics, Inc. Transdermal delivery of large agents
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
EP3542788A1 (de) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topische zusammensetzung enthaltend calcipotriol und betamethason dipropionat

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1165238A (en) * 1980-03-12 1984-04-10 Demetrios P. Papahadjopoulos Activated liposomes and method
AU609242B2 (en) * 1988-01-29 1991-04-26 Novartis Ag Cyclosporin compositions
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
CA1337397C (en) * 1988-09-29 1995-10-24 Hideo Nakajima Emulsified composition
AU614465B2 (en) * 1989-04-05 1991-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
JP2785981B2 (ja) * 1989-11-20 1998-08-13 株式会社資生堂 乳化組成物
US5529785A (en) * 1993-05-12 1996-06-25 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
EP0570829B1 (de) * 1992-05-18 2001-04-25 CicloMulsion AG Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur intravenösen Applikation sowie Verfahren zu ihrer Herstellung
WO1994008603A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Compositions
WO1994008605A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Therapeutic microemulsions
DE4338086A1 (de) * 1993-11-08 1995-05-11 Dietl Hans Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur oralen Applikation sowie Verfahren zu ihrer Herstellung
GB9601120D0 (en) * 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
JP2000509021A (ja) 2000-07-18
DE69727849T2 (de) 2004-07-29
ES2217368T3 (es) 2004-11-01
WO1997036611A1 (en) 1997-10-09
US5660858A (en) 1997-08-26
EP0799620B1 (de) 2004-03-03
JP4212113B2 (ja) 2009-01-21
CA2250970A1 (en) 1997-10-09
CA2250970C (en) 2012-10-16
EP0799620A1 (de) 1997-10-08
DE69727849D1 (de) 2004-04-08
AU2588597A (en) 1997-10-22

Similar Documents

Publication Publication Date Title
ATE260673T1 (de) Cyclosporin-emulsionen
ES2094031T3 (es) Emulsion de aceite en agua utilizable para la obtencion de una crema.
DK0759773T3 (da) Tårekirtelspecifikke emulsioner til topisk påføring på okulært væv
DK312583D0 (da) Kortikoidholdigt praeparat til topisk applikation
ATE497384T1 (de) Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen
ES2043279T3 (es) Emulsion comestible de aceite en agua.
DE60131862D1 (de) Herstellung von vitaminemulsionen und konzentrate davon
ATE283031T1 (de) Nichtirritierende kosmetische und pharmazeutische zusammensetzungen
AR002965A1 (es) Emulsión aceite-en agua transparente cuyos glóbulos de aceite tienen un tamaño promedio inferior a 100 nm y que comprede una fase lipídica anfífla, suaplicacion, procedimiento para prepararla, procedimiento de tratamiento no terapeutico que la utiliza y composicion de uso topico que la contiene.
ATE332119T1 (de) Kosmetische und dermatologische zubereitungen auf der grundlage von o/w-emulsionen
ES2123800T3 (es) Composicion para el cuidado de la piel que contiene vaselina emulsionada.
RU2000112410A (ru) Стабильные косметические композиции
ATE270537T1 (de) Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut
DE69130706D1 (de) Verfahren zur beseitigung von ausgelaufendem öl
ATE331498T1 (de) Kosmetische und dermatologische zubereitungen auf der grundlage von o/w-emulsionen
EP1459801A3 (de) Wasser-in-Öl Emulsionen, insbesondere für Sonnenschutz, und Verfahren zu deren Herstellung
ATE219353T1 (de) O/w-emulsion enthaltende fibern und ihre verwendung in der kosmetik
ES2189891T3 (es) Emulsiones de liquidos optimizadas para la hidrolisis y uso de las mismas.
EA200300680A1 (ru) Масло для кожи, содержащее растворимые в масле компоненты
DE59812416D1 (de) Splissregenerierende haarbehandlungsmittel
FR2721800B1 (fr) Nouveaux concentres emulsionnables renfermant un u plussieurs pesticides
BR0304135A (pt) Método melhorado para a formação de uma fase estável de emulsão baseada em emulsificante polimérico, e, método para melhorar a capacidade de homogeneização de um explosivo em emulsão
ATE329570T1 (de) Emulsion enthaltend siliconöl- und co- lösungsmittelsystem enhaltend fettlösliche kosmetische wirkstoffe und daraus hergestelleten kosmetischen zubereitungen
EP0648497A4 (de) Emulsionen von aureobasidin.
DE50009125D1 (de) Zubereitungen vom emulsionstyp w/o mit erhöhtem wassergehalt mit einem gehalt an mittelpolaren lipiden

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties