KR840003028A - 종양치료제의 오일상 조성물의 제조방법 - Google Patents
종양치료제의 오일상 조성물의 제조방법 Download PDFInfo
- Publication number
- KR840003028A KR840003028A KR1019830000188A KR830000188A KR840003028A KR 840003028 A KR840003028 A KR 840003028A KR 1019830000188 A KR1019830000188 A KR 1019830000188A KR 830000188 A KR830000188 A KR 830000188A KR 840003028 A KR840003028 A KR 840003028A
- Authority
- KR
- South Korea
- Prior art keywords
- tumor therapeutic
- oily composition
- preparing
- preparing oily
- oily
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims 2
- 230000001225 therapeutic effect Effects 0.000 title claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 150000003983 crown ethers Chemical class 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- -1 polyoxyethylene Polymers 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000001959 sucrose esters of fatty acids Substances 0.000 claims 1
- 235000010965 sucrose esters of fatty acids Nutrition 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 수용성 또는 오일에 거의 녹지 않는 종양치료제 하나 이상과 크라운 에테르, 레시틴, 폴리에틸렌글리콜, 프로필렌글리콜, 비타민 E, 폴리옥시에틸렌 알킬에테르 및 지방산의 슈크로즈 에스테르 중에서 선택된, 오일상 베히클 중의 가용화 보조제 하나 이상을 지방 및 오일 하나 이상에 용해 또는 유화시킴을 특징으로 하여 종양치료제의 오일상 조성물을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57-7997 | 1982-01-20 | ||
JP799782A JPS58124714A (ja) | 1982-01-20 | 1982-01-20 | 抗腫瘍物質の油性組成物 |
JP7997 | 1982-01-20 | ||
JP21504982 | 1982-12-08 | ||
JP215049 | 1987-08-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840003028A true KR840003028A (ko) | 1984-08-13 |
KR900005044B1 KR900005044B1 (ko) | 1990-07-18 |
Family
ID=26342413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830000188A KR900005044B1 (ko) | 1982-01-20 | 1983-01-19 | 종양치료제의 오일상 조성물의 제조방법 |
Country Status (6)
Country | Link |
---|---|
US (1) | US4578391A (ko) |
KR (1) | KR900005044B1 (ko) |
DE (1) | DE3301638A1 (ko) |
FR (1) | FR2519864B1 (ko) |
GB (1) | GB2114885B (ko) |
IT (1) | IT1193128B (ko) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6028916A (ja) * | 1983-07-13 | 1985-02-14 | Yamanouchi Pharmaceut Co Ltd | アクラルビシンまたはその塩酸塩の油性組成物 |
HU197212B (en) * | 1985-08-02 | 1989-03-28 | Merz & Co Gmbh & Co | Process for producing pharmaceuticals with antiviral and antitumour effect |
US5389366A (en) * | 1986-09-19 | 1995-02-14 | Yamanouchi Pharmaceutical Co., Ltd. | Neocarzinostatin derivative composition for oral administration |
JP2556865B2 (ja) * | 1986-09-19 | 1996-11-27 | 山之内製薬株式会社 | ネオカルチノスタチン誘導体の非注射投与用組成物 |
US5051406A (en) * | 1987-03-04 | 1991-09-24 | Nippon Hypox Laboratories Incorporated | Pharmaceutical composition using albumin as a carrier and process for producing the same |
JPH0794377B2 (ja) * | 1987-07-22 | 1995-10-11 | 呉羽化学工業株式会社 | エストラジオール誘導体を含有する注射剤 |
US5216011A (en) * | 1989-09-01 | 1993-06-01 | Bristol-Myers Squibb Co. | Stable solutions of mitomycin c |
US5496533A (en) * | 1992-07-31 | 1996-03-05 | Australian Nuclear Science & Technology Organisation | Rhenium complexes |
SI9300468A (en) * | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
GB9323588D0 (en) * | 1993-11-16 | 1994-01-05 | Cortecs Ltd | Hydrophobic preparation |
GB9422990D0 (en) * | 1994-11-15 | 1995-01-04 | Cortecs Ltd | Immunogenic compositions |
GB9424901D0 (en) * | 1994-12-09 | 1995-02-08 | Cortecs Ltd | Sequestration Agents |
US5891469A (en) * | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
GB9618420D0 (en) | 1996-09-04 | 1996-10-16 | Scotia Holdings Plc | Fatty acid treatment |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6117852A (en) * | 1997-12-29 | 2000-09-12 | National Science Council | Boron-containing lipiodol for boron neutron capture therapy of hepatoma |
IL131217A0 (en) * | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US8052982B2 (en) * | 1998-07-20 | 2011-11-08 | Peptech Animal Health Pty Limited | Bioimplant formulation comprising lecithin and stearin |
AU755443C (en) * | 1998-07-20 | 2006-08-17 | Virbac (Australia) Pty Limited | Bioimplant formulation |
MXPA01000674A (es) | 1998-07-20 | 2002-04-08 | Peptech Ltd | Formulacion de bioimplante. |
US6463256B2 (en) * | 1999-03-31 | 2002-10-08 | Hewlett-Packard Company | Duplexing module for printer |
US6437006B1 (en) | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
US6420358B1 (en) | 1999-09-27 | 2002-07-16 | American Cyanamid Company | Vasopressin antagonist and diuretic combination |
US6352718B1 (en) | 1999-09-27 | 2002-03-05 | American Cyanamid Company | Vasopressin antagonist formulation and process |
US6831079B1 (en) | 1999-09-27 | 2004-12-14 | American Cyanamid Company | Vasopressin agonist formulation and process |
AU2001225432A1 (en) * | 2000-01-20 | 2001-07-31 | Supratek Pharma, Inc. | Novel podophyllotoxin compositions |
AUPR644301A0 (en) * | 2001-07-17 | 2001-08-09 | Unisearch Limited | Method and composition for treatment of cancer |
US7094771B2 (en) * | 2002-07-15 | 2006-08-22 | National Tsing Hua University | Pharmaceutical composition for boron neutron capture therapy containing triphenylboroxin |
JP2006056781A (ja) * | 2002-11-15 | 2006-03-02 | Bioserentack Co Ltd | 界面活性剤を含む固形化製剤 |
EP1592760A4 (en) * | 2003-01-31 | 2009-08-12 | Smithkline Beecham Corp | AS FIXED DISPERSIONS, COMPOSITIONS |
US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
CN102260216A (zh) * | 2010-05-28 | 2011-11-30 | 李茂全 | 5-氟尿嘧啶亲脂性衍生物碘化油 |
CN111298189A (zh) * | 2018-12-11 | 2020-06-19 | 陈传果 | 一种易于推注的碘化油栓塞剂及其制备方法 |
CN109821055A (zh) * | 2019-02-01 | 2019-05-31 | 厦门大学 | 一种药物-碘油溶剂及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5393M (ko) * | 1964-09-22 | 1967-10-30 | ||
US4104461A (en) * | 1973-04-16 | 1978-08-01 | Research Corporation | 2,2'-Anhydro-β-D-arabinofuranosyl-5-fluorocytosine |
US4011661A (en) * | 1973-10-30 | 1977-03-15 | Kyowa Hakko Kogyo Co., Ltd. | Powdered emulsion product and method of production |
JPS5439098A (en) * | 1977-08-31 | 1979-03-24 | Kyowa Hakko Kogyo Co Ltd | Mitomycin c derivatives |
US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
GB2046092B (en) * | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
JPS5686114A (en) * | 1979-12-17 | 1981-07-13 | Medeiseru Kenkyusho:Kk | Pharmaceutical composition for suppository |
-
1983
- 1983-01-13 US US06/457,636 patent/US4578391A/en not_active Expired - Fee Related
- 1983-01-19 DE DE19833301638 patent/DE3301638A1/de active Granted
- 1983-01-19 KR KR1019830000188A patent/KR900005044B1/ko not_active IP Right Cessation
- 1983-01-19 IT IT67055/83A patent/IT1193128B/it active
- 1983-01-20 FR FR8300842A patent/FR2519864B1/fr not_active Expired
- 1983-01-20 GB GB08301566A patent/GB2114885B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
KR900005044B1 (ko) | 1990-07-18 |
GB2114885A (en) | 1983-09-01 |
IT8367055A0 (it) | 1983-01-19 |
IT1193128B (it) | 1988-06-02 |
FR2519864B1 (fr) | 1985-09-27 |
US4578391A (en) | 1986-03-25 |
DE3301638A1 (de) | 1983-08-04 |
GB2114885B (en) | 1985-09-04 |
GB8301566D0 (en) | 1983-02-23 |
DE3301638C2 (ko) | 1989-08-24 |
FR2519864A1 (fr) | 1983-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19950710 Year of fee payment: 6 |
|
LAPS | Lapse due to unpaid annual fee |