ATE259678T1 - Kapillare drucksysteme - Google Patents

Kapillare drucksysteme

Info

Publication number
ATE259678T1
ATE259678T1 AT99946833T AT99946833T ATE259678T1 AT E259678 T1 ATE259678 T1 AT E259678T1 AT 99946833 T AT99946833 T AT 99946833T AT 99946833 T AT99946833 T AT 99946833T AT E259678 T1 ATE259678 T1 AT E259678T1
Authority
AT
Austria
Prior art keywords
systems
capillary pressure
pressure systems
methods
wide variety
Prior art date
Application number
AT99946833T
Other languages
English (en)
Inventor
Tidhar Shalon
Joseph Maurino
Loren D Titsworth
Joeben Bevirt
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Application granted granted Critical
Publication of ATE259678T1 publication Critical patent/ATE259678T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/0036—Nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00385—Printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B01L2300/105—Means to control humidity and/or other gases using desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/021—Drop detachment mechanisms of single droplets from nozzles or pins non contact spotting by inertia, i.e. abrupt deceleration of the nozzle or pin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/022—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle
    • B01L2400/025—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle tapping tip on substrate
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Ink Jet (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Printers Or Recording Devices Using Electromagnetic And Radiation Means (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)
  • Printing Methods (AREA)
  • Common Mechanisms (AREA)
  • Coating Apparatus (AREA)
  • Electroluminescent Light Sources (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AT99946833T 1998-09-09 1999-09-09 Kapillare drucksysteme ATE259678T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/150,502 US6309891B1 (en) 1998-09-09 1998-09-09 Capillary printing systems
PCT/US1999/020692 WO2000013796A1 (en) 1998-09-09 1999-09-09 Capillary printing systems

Publications (1)

Publication Number Publication Date
ATE259678T1 true ATE259678T1 (de) 2004-03-15

Family

ID=22534841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99946833T ATE259678T1 (de) 1998-09-09 1999-09-09 Kapillare drucksysteme

Country Status (8)

Country Link
US (5) US6309891B1 (de)
EP (2) EP1374998A1 (de)
JP (2) JP2003519360A (de)
AT (1) ATE259678T1 (de)
AU (1) AU748153B2 (de)
CA (1) CA2342785A1 (de)
DE (1) DE69914922D1 (de)
WO (1) WO2000013796A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285422B1 (en) * 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
DE19754000A1 (de) * 1997-12-05 1999-06-17 Max Planck Gesellschaft Vorrichtung und Verfahren zur elektrisch ausgelösten Mikrotropfenabgabe mit einem Dispensierkopf
EP0955084B1 (de) 1998-04-27 2006-07-26 Corning Incorporated Verfahren zur Ablage von biologischen Proben mit hilfe eines nachgezogenen Kapillar-speichers
US6884626B1 (en) * 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
US6551557B1 (en) * 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US20040047765A1 (en) * 1998-10-16 2004-03-11 Gordon Steven J. Automated robotic workstation and methods of operation thereof
US6306599B1 (en) * 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
JP2001033463A (ja) * 1999-07-23 2001-02-09 Cosmo Tec:Kk 液体分注装置
CA2391758C (en) * 1999-08-13 2010-02-16 Cartesian Technologies, Inc. Apparatus for liquid sample handling
US7160511B2 (en) * 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
WO2001062377A2 (en) 2000-02-22 2001-08-30 Genospectra, Inc. Microarray fabrication techniques and apparatus
AU6291301A (en) 2000-02-22 2001-09-03 Genospectra, Inc. Microarray fabrication techniques and apparatus
US6706538B1 (en) * 2000-02-29 2004-03-16 Boston Innovation Inc. Microvolume liquid dispensing array
JP3474513B2 (ja) * 2000-03-09 2003-12-08 沖電気工業株式会社 キャピラリ
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6878554B1 (en) 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
US6387330B1 (en) * 2000-04-12 2002-05-14 George Steven Bova Method and apparatus for storing and dispensing reagents
US6610253B2 (en) * 2000-05-31 2003-08-26 Autosplice, Inc. Liquid pin transfer assembly with common pin bias
US6579499B1 (en) * 2000-05-31 2003-06-17 Autosplice, Inc. Liquid compound pin replicator with weight bias
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
JP2002001092A (ja) * 2000-06-22 2002-01-08 Shimadzu Corp 排液装置
US20050106621A1 (en) * 2000-08-16 2005-05-19 Winegarden Neil A. Devices and methods for producing microarrays of biological samples
US6902702B1 (en) * 2000-08-16 2005-06-07 University Health Network Devices and methods for producing microarrays of biological samples
US7731904B2 (en) * 2000-09-19 2010-06-08 Canon Kabushiki Kaisha Method for making probe support and apparatus used for the method
US6911181B1 (en) * 2000-10-03 2005-06-28 Isis Pharmaceuticals, Inc. Self-dispensing storage device
EP1332000B1 (de) 2000-10-30 2012-06-20 Sequenom, Inc. Verfahren zur aufbringung von submikroliter fluid-volumina auf ein substrat
FR2821284B1 (fr) * 2001-02-23 2004-01-23 Univ Pasteur Appareil pour le prelevement et de depot en microreseaux de solutions
CN1385518A (zh) * 2001-04-23 2002-12-18 株式会社百尼尔 生物学试料的微细排列用点样装置及该装置中使用的点样针
US7041257B2 (en) * 2001-09-25 2006-05-09 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
JP2005502448A (ja) * 2001-06-20 2005-01-27 サイトノーム インコーポレーテッド 微細化２ピン液体試料供給システム
US6855538B2 (en) * 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
US7402286B2 (en) * 2001-06-27 2008-07-22 The Regents Of The University Of California Capillary pins for high-efficiency microarray printing device
KR100377783B1 (ko) * 2001-07-11 2003-03-29 주식회사 져스텍 브러시리스 리니어모터의 요크 구조
WO2003006164A1 (en) * 2001-07-11 2003-01-23 Universisty Of Southern California Dna probe synthesis on chip on demand by mems ejector array
US7153699B2 (en) * 2001-12-21 2006-12-26 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US20070054408A1 (en) * 2001-09-25 2007-03-08 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
WO2003031044A2 (en) * 2001-10-05 2003-04-17 Vanderbilt University Capillary tube printing tips for microarray printing
US20030148539A1 (en) * 2001-11-05 2003-08-07 California Institute Of Technology Micro fabricated fountain pen apparatus and method for ultra high density biological arrays
US6936474B2 (en) * 2001-11-05 2005-08-30 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
US20040026366A1 (en) * 2001-11-28 2004-02-12 Andre Sharon Method of manufacturing ultra-precise, self-assembled micro systems
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
EP1323465A1 (de) * 2001-12-31 2003-07-02 Corning Incorporated Flexibler Druckkopf fuer Matrix von hoher dichte mit Einrichtung und Methode zur Ausrrichtung von Pinplatte, Behältern und Substrat zueinander
US6827905B2 (en) * 2002-01-14 2004-12-07 Becton, Dickinson And Company Pin tool apparatus and method
DE10238266A1 (de) * 2002-02-28 2003-11-06 Ibidi Gmbh Mikrofluidsystem
AU2003218727A1 (en) * 2002-03-11 2003-09-22 Axaron Bioscience Ag Method for applying a substance to a substrate
JP3732457B2 (ja) * 2002-05-20 2006-01-05 日立ソフトウエアエンジニアリング株式会社 スポットピン
US7144554B1 (en) * 2002-08-02 2006-12-05 Hamilton Company Ultra low volume probe
AU2003259041A1 (en) * 2002-08-15 2004-03-03 Proteoplex, Inc. Methods and apparatus for preparing and assaying biological samples to determine protein concentration
US20030166263A1 (en) * 2002-12-30 2003-09-04 Haushalter Robert C. Microfabricated spotting apparatus for producing low cost microarrays
DE10327380A1 (de) * 2003-06-18 2005-01-13 Eppendorf Ag System zum Dosieren von Probenflüssigkeit
WO2005007289A2 (en) * 2003-07-11 2005-01-27 Genomic Solutions Inc. Apparatus and methods for liquid sample handling based on capillary action
US20050051600A1 (en) * 2003-09-10 2005-03-10 Texas Instruments Incorporated Method and system for stud bumping
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
CA2545941A1 (en) 2003-11-14 2005-06-23 Drexel University Method and apparatus for computer-aided tissue engineering for modeling, design and freeform fabrication of tissue scaffolds, constructs, and devices
KR100647282B1 (ko) * 2003-12-24 2006-11-17 삼성전자주식회사 ＤＮＡ 마이크로어레이 스폿팅(Ｓｐｏｔｉｎｇ) 장치 및이를 이용한 스폿팅 방법
BE1015896A3 (nl) * 2004-02-06 2005-11-08 Imhold Nv Werkwijze voor het vervaardigen van een veerkrachtig lichaam dat kan worden toegepast in kussens, matrassen of dergelijke.
JP4624133B2 (ja) * 2004-03-29 2011-02-02 京セラ株式会社 液体印刷ピン
CN100496749C (zh) 2004-07-06 2009-06-10 犹他大学研究基金会 对微阵列和其他微型装置进行高浓度点沉积的点样装置及方法
DE202005001613U1 (de) * 2005-01-31 2005-03-31 Cybio Ag Spitze für Pipetier- oder Dispensiergeräte
WO2006094049A2 (en) * 2005-03-01 2006-09-08 Parallel Synthesis Technologies, Inc. Polymeric fluid transfer and printing devices
GB2426334A (en) * 2005-05-20 2006-11-22 Orion Diagnostica Oy Application of a reagent to a matrix material
US20080216698A1 (en) * 2007-03-06 2008-09-11 Bio-Rad Laboratories, Inc. Microdot printing head
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
KR101554448B1 (ko) * 2011-07-25 2015-09-18 씨에스아이알 어레이 프린팅
US9029297B2 (en) 2011-07-25 2015-05-12 Csir Array printing
US9012375B2 (en) 2011-07-25 2015-04-21 Csir Array printing
US9791080B2 (en) 2012-03-12 2017-10-17 Idex Health & Science Llc Microfluidic interconnect
US10300450B2 (en) 2012-09-14 2019-05-28 Carterra, Inc. Method and device for depositing a substance on a submerged surface

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894671A (en) 1971-01-06 1975-07-15 Kulicke & Soffa Ind Inc Semiconductor wire bonder
LU77642A1 (de) * 1976-07-09 1977-10-03
US4142656A (en) 1976-12-17 1979-03-06 Eastman Kodak Company Drop former utilizing gas pressure
JPS55161238U (de) * 1979-05-04 1980-11-19
US4441532A (en) 1982-05-03 1984-04-10 The United States Of America As Represented By The Secretary Of The Army Apparatus and method for generating single droplets
US4511534A (en) * 1982-05-26 1985-04-16 John T. Bennett Liquid transfer device
US4461328A (en) * 1982-06-04 1984-07-24 Drummond Scientific Company Pipette device
US4498510A (en) * 1982-08-20 1985-02-12 Minshew Jr Edward C Device for drawing, holding and dispensing liquid
US4513190A (en) * 1983-01-03 1985-04-23 Small Precision Tools, Inc. Protection of semiconductor wire bonding capillary from spark erosion
US4478094A (en) * 1983-01-21 1984-10-23 Cetus Corporation Liquid sample handling system
DE3407849A1 (de) * 1984-02-29 1985-08-29 Alois 3201 Algermissen Höft Verfahren und einrichtung zum gleichzeitigen aufbringen einer vielzahl von fluessigkeitsproben auf einen objekttraeger
US4731335A (en) * 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
JPS6341037A (ja) 1986-08-06 1988-02-22 Mitsubishi Electric Corp ワイヤボンデイング装置
US5000921A (en) * 1986-10-24 1991-03-19 Hanaway Richard W Multiple pipette samples
US4844298A (en) * 1987-03-11 1989-07-04 Sumitomo Electric Industries, Ltd. Apparatus for automatically dispensing accurately a predetermined quantity of liquids required to be stored at constant temperatures
US4815325A (en) 1988-04-22 1989-03-28 Dynatech Precision Sampling Corporation Capillary fluid injectors
GB8809611D0 (en) 1988-04-22 1988-05-25 Darougar S Deposition apparatus
US4975250A (en) * 1989-08-21 1990-12-04 Fisher Scientific Co. Aligned slideholder and assembly
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
US5026526A (en) * 1990-02-09 1991-06-25 Eastman Kodak Company Automated capping means for analyzer pipette
DE4024545A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
US5525302A (en) * 1991-02-01 1996-06-11 Astle; Thomas W. Method and device for simultaneously transferring plural samples
US5189787A (en) * 1991-07-30 1993-03-02 Hewlett-Packard Company Attachment of a flexible circuit to an ink-jet pen
GB9208386D0 (en) * 1992-04-16 1992-06-03 Amersham Int Plc Storage and dispensing device for liquids
US5343909A (en) * 1992-12-17 1994-09-06 Jack Goodman Liquid transfer device
US5454491A (en) * 1993-08-30 1995-10-03 World Precision Instruments, Inc. Non-metallic precision fluid transfer devices
US5440940A (en) * 1994-03-18 1995-08-15 Wilkins; Judd R. Pipette-syringe-tubular microbial retrieval and sampler
JP3420824B2 (ja) * 1994-04-15 2003-06-30 富士写真フイルム株式会社 乾式分析フイルム片への試料液点着方法およびその装置
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5601980A (en) 1994-09-23 1997-02-11 Hewlett-Packard Company Manufacturing method and apparatus for biological probe arrays using vision-assisted micropipetting
IT1267355B1 (it) * 1994-12-22 1997-01-28 Olivetti Canon Ind Spa Dispositivo di ricovero per testina di stampa a getto di inchiostro.
US5551487A (en) * 1995-03-10 1996-09-03 Hewlett-Packard Company Micro-dispenser for preparing assay plates
US5662261A (en) * 1995-04-11 1997-09-02 Micron Technology, Inc. Wire bonding capillary
US5763278A (en) * 1995-11-01 1998-06-09 Tecan Ag Automated pipetting of small volumes
US5747102A (en) * 1995-11-16 1998-05-05 Nordson Corporation Method and apparatus for dispensing small amounts of liquid material
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
KR19980064247A (ko) * 1996-12-19 1998-10-07 윌리엄비.켐플러 와이어 본딩 캐필러리의 연속 자동 회전
KR19980064245A (ko) * 1996-12-19 1998-10-07 윌리엄비.켐플러 와이어 본딩 캐필러리의 단계적 자동 회전
EP2295988A2 (de) 1996-12-31 2011-03-16 High Throughput Genomics, Inc. Multiplex-Analysevorrichtung zur Analyse von Molekülen und zugehöriges Herstellungsverfahren
JPH111046A (ja) * 1997-06-12 1999-01-06 Brother Ind Ltd 記録ヘッドユニットの梱包体及び記録ヘッドユニットの梱包方法
US5882930A (en) * 1997-11-10 1999-03-16 Hyseq, Inc. Reagent transfer device
US6158647A (en) * 1998-09-29 2000-12-12 Micron Technology, Inc. Concave face wire bond capillary

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WO2000013796A1 (en) 2000-03-16
CA2342785A1 (en) 2000-03-16
US20010044157A1 (en) 2001-11-22
US20010013298A1 (en) 2001-08-16
US20020064887A1 (en) 2002-05-30
AU748153B2 (en) 2002-05-30
WO2000013796A9 (en) 2000-08-17
AU5915399A (en) 2000-03-27
EP1374998A1 (de) 2004-01-02
EP1109624B1 (de) 2004-02-18
EP1109624A1 (de) 2001-06-27
US6309891B1 (en) 2001-10-30
DE69914922D1 (de) 2004-03-25
US20010013295A1 (en) 2001-08-16
JP2003519360A (ja) 2003-06-17

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