ATE258227T1 - Methode zur in vitro reproduktion der rna- abhängigen rna polymerase- und terminalen nukleotidyltransferase-aktivität des hepatitis c virus (hcv) - Google Patents

Methode zur in vitro reproduktion der rna- abhängigen rna polymerase- und terminalen nukleotidyltransferase-aktivität des hepatitis c virus (hcv)

Info

Publication number
ATE258227T1
ATE258227T1 AT96916289T AT96916289T ATE258227T1 AT E258227 T1 ATE258227 T1 AT E258227T1 AT 96916289 T AT96916289 T AT 96916289T AT 96916289 T AT96916289 T AT 96916289T AT E258227 T1 ATE258227 T1 AT E258227T1
Authority
AT
Austria
Prior art keywords
hcv
hepatitis
virus
rna
transferase activity
Prior art date
Application number
AT96916289T
Other languages
English (en)
Inventor
Francesco Raffaele De
Licia Tomei
Sven-Erik Behrens
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11403393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE258227(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Application granted granted Critical
Publication of ATE258227T1 publication Critical patent/ATE258227T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96916289T 1995-05-25 1996-05-24 Methode zur in vitro reproduktion der rna- abhängigen rna polymerase- und terminalen nukleotidyltransferase-aktivität des hepatitis c virus (hcv) ATE258227T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95RM000343A IT1278077B1 (it) 1995-05-25 1995-05-25 Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
PCT/IT1996/000106 WO1996037619A1 (en) 1995-05-25 1996-05-24 Method for reproducing in vitro the rna-dependent rna polymerase and terminal nucleotidyl transferase activities encoded by hepatitis c virus (hcv)

Publications (1)

Publication Number Publication Date
ATE258227T1 true ATE258227T1 (de) 2004-02-15

Family

ID=11403393

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916289T ATE258227T1 (de) 1995-05-25 1996-05-24 Methode zur in vitro reproduktion der rna- abhängigen rna polymerase- und terminalen nukleotidyltransferase-aktivität des hepatitis c virus (hcv)

Country Status (13)

Country Link
US (2) US6383768B1 (de)
EP (1) EP0842276B1 (de)
JP (1) JP3187432B2 (de)
AT (1) ATE258227T1 (de)
AU (1) AU708431B2 (de)
BR (1) BR9609178A (de)
CA (1) CA2220873C (de)
DE (1) DE69631375T2 (de)
DK (1) DK0842276T3 (de)
ES (1) ES2211956T3 (de)
IT (1) IT1278077B1 (de)
PT (1) PT842276E (de)
WO (1) WO1996037619A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1278077B1 (it) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
US6461845B1 (en) * 1995-09-27 2002-10-08 Emory University Recombinant hepatitis C virus RNA replicase
WO1997012033A1 (en) * 1995-09-27 1997-04-03 Emory University Recombinant hepatitis c virus rna replicase
CA2312484A1 (en) * 1997-12-11 1999-06-17 Smithkline Beecham Corporation Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds
IL138804A0 (en) * 1998-04-02 2001-10-31 Viropharma Inc Hepatitis c virus ns5b nucleic acids and proteins
WO1999067396A1 (fr) * 1998-06-24 1999-12-29 International Reagents Corporation Gene de l'arn polymerase derive du virus de l'hepatite c
AU2181800A (en) * 1998-12-10 2000-06-26 Eli Lilly And Company Primer-independent rna synthesis catalyzed by hcv polymerase
US6297005B1 (en) 1999-05-04 2001-10-02 Schering Corporation De novo priming activity of hepatitis C virus replicase
WO2001038538A1 (en) * 1999-11-23 2001-05-31 Viropharma Incorporated Polymerase compositions and methods of use thereof
US7018796B2 (en) 2000-04-07 2006-03-28 Shionogi & Co., Ltd. Preincubation assay methods
KR20020010241A (ko) * 2000-07-28 2002-02-04 허영섭 Ｃ형 간염 바이러스 ｒｎａ-의존성 ｒｎａ 중합효소의대량 발현 기구 및 이로부터 발현된 융합단백질을 이용한효소활성 분석방법
EP2050822B1 (de) 2001-01-23 2013-07-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis C-Virus-Replicone und repliconerweiterte Zellen
EP2172552A3 (de) 2001-10-11 2010-07-21 Merck Sharp & Dohme Corp. Rekombinante Nukleinsäuren beinhaltend Regionen von AD6
EP1436397B1 (de) 2001-10-11 2010-05-12 Merck Sharp & Dohme Corp. Hepatitis-c-virus-impfstoff
ATE426682T1 (de) 2002-04-16 2009-04-15 Merck & Co Inc Hepatitis-c-virus-testsysteme
TW200400818A (en) 2002-05-21 2004-01-16 Wyeth Corp Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
TW200400963A (en) 2002-05-21 2004-01-16 Wyeth Corp R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
US20040142322A1 (en) * 2002-10-07 2004-07-22 Schering Corporation Continuous non-radioactive polymerase assay
AU2003304040A1 (en) * 2002-10-08 2004-11-04 Viropharma Incorporated Anthranilic acid derivatives useful in treating infection with hepatitis c virus
US7807455B2 (en) 2003-02-13 2010-10-05 Merck Sharp & Dohme Corp. Method to confer cell culture replication activity to different Hepatitis C virus isolates
US8354518B2 (en) 2003-11-05 2013-01-15 Merck Sharp & Dohme Corp. HCV replicons containing NS5B from genotype 2B
US7329732B2 (en) 2004-01-09 2008-02-12 Merck & Co., Inc. HCV RNA-dependent RNA polymerase
CA2560699A1 (en) * 2004-03-24 2005-10-13 Achillion Pharmaceuticals, Inc. Quantitative assay for detection of newly synthesized rna in a cell-free system and identification of rna synthesis inhibitors
WO2006046030A2 (en) 2004-10-26 2006-05-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Tetracyclic indole derivatives as antiviral agents
CA2604442A1 (en) * 2005-04-11 2006-10-19 Mingjun Huang Pharmaceutical compositions for and methods of inhibiting hcv replication
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
US20090203008A1 (en) 2006-06-08 2009-08-13 Ludmerer Steven W Rapid method to determine inhibitor sensitivity of NS3/4A protease sequences cloned from clinical samples
GB0625345D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0625349D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
CN101611025A (zh) 2006-12-22 2009-12-23 先灵公司 5,6-环化的吲哚衍生物及其使用方法
WO2008082488A1 (en) 2006-12-22 2008-07-10 Schering Corporation 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections
RU2009127855A (ru) 2006-12-22 2011-01-27 Шеринг Корпорейшн (US) 4,5 циклоаннелированные производные индола для лечения или предотвращения вируса гепатита с (hcv) и родственных вирусных инфекций
EP2118301A4 (de) 2007-03-09 2011-04-20 Merck Sharp & Dohme In-vivo-hcv-resistenz gegen anti-virale hemmer
WO2009010783A1 (en) 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis c infections
KR20100067652A (ko) 2007-08-29 2010-06-21 쉐링 코포레이션 치환된 인돌 유도체 및 이의 사용방법
CN101842353A (zh) 2007-08-29 2010-09-22 先灵公司 用于治疗病毒感染的2,3-取代的吲哚衍生物
CN101842374A (zh) 2007-08-29 2010-09-22 先灵公司 用于治疗病毒感染的2，3-取代的氮杂吲哚衍生物
US8377928B2 (en) 2007-11-16 2013-02-19 Merck Sharp & Dohme Corp. 3-aminosulfonyl substituted indole derivatives and methods of use thereof
CA2705586A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-heterocyclic substituted indole derivatives and methods of use thereof
US8901139B2 (en) 2008-06-13 2014-12-02 Merck Sharp & Dohme Corp. Tricyclic indole derivatives and methods of use thereof
EP2166016A1 (de) 2008-09-18 2010-03-24 Centocor Ortho Biotech Products L.P. Phosphoramidat-Derivate von Nukleosiden
WO2010082050A1 (en) 2009-01-16 2010-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
GB0906026D0 (en) 2009-04-07 2009-05-20 Angeletti P Ist Richerche Bio Therapeutic compounds
RU2553656C2 (ru) 2009-09-29 2015-06-20 ЯНССЕН ПРОДАКТС, Эл.Пи. Фосфорамидатные производные нуклеозидов
WO2014139587A1 (en) 2013-03-15 2014-09-18 Okairòs Ag Improved poxviral vaccines
WO2017025782A1 (en) 2014-09-17 2017-02-16 Glaxosmithkline Biologicals Sa Improved poxviral vaccines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464287A1 (de) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, Non-B Hepatitis Virus genomisches DNS und Antigenpolypeptide
NZ238681A (en) * 1990-06-25 1992-03-26 Univ Osaka Res Found Non-a, non-b hepatitis virus particles and their production
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
IT1272179B (it) * 1994-02-23 1997-06-16 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv.
IT1278077B1 (it) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
WO1997012033A1 (en) 1995-09-27 1997-04-03 Emory University Recombinant hepatitis c virus rna replicase

Also Published As

Publication number Publication date
BR9609178A (pt) 1999-05-04
EP0842276A1 (de) 1998-05-20
ES2211956T3 (es) 2004-07-16
DE69631375D1 (de) 2004-02-26
AU708431B2 (en) 1999-08-05
DK0842276T3 (da) 2004-05-03
JP3187432B2 (ja) 2001-07-11
CA2220873A1 (en) 1996-11-28
WO1996037619A1 (en) 1996-11-28
PT842276E (pt) 2004-05-31
IT1278077B1 (it) 1997-11-17
US20020164722A1 (en) 2002-11-07
US6383768B1 (en) 2002-05-07
DE69631375T2 (de) 2004-11-04
US7399605B2 (en) 2008-07-15
ITRM950343A0 (it) 1995-05-25
EP0842276B1 (de) 2004-01-21
JPH10507370A (ja) 1998-07-21
CA2220873C (en) 2000-10-24
ITRM950343A1 (it) 1996-11-25
AU5909896A (en) 1996-12-11

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