ATE256670T1 - Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors - Google Patents

Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors

Info

Publication number
ATE256670T1
ATE256670T1 AT00992436T AT00992436T ATE256670T1 AT E256670 T1 ATE256670 T1 AT E256670T1 AT 00992436 T AT00992436 T AT 00992436T AT 00992436 T AT00992436 T AT 00992436T AT E256670 T1 ATE256670 T1 AT E256670T1
Authority
AT
Austria
Prior art keywords
antagonists
adrenergic receptor
carboxamide derivatives
isoxazole carboxamide
alpha1 adrenergic
Prior art date
Application number
AT00992436T
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Elena Poggesi
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Application granted granted Critical
Publication of ATE256670T1 publication Critical patent/ATE256670T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00992436T 1999-10-18 2000-10-16 Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors ATE256670T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI002173A IT1314191B1 (it) 1999-10-18 1999-10-18 Derivati isossazolcarbossamidici
PCT/EP2000/010144 WO2001029015A2 (en) 1999-10-18 2000-10-16 Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists

Publications (1)

Publication Number Publication Date
ATE256670T1 true ATE256670T1 (de) 2004-01-15

Family

ID=11383797

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00992436T ATE256670T1 (de) 1999-10-18 2000-10-16 Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors

Country Status (25)

Country Link
EP (1) EP1226131B1 (de)
JP (1) JP2003512362A (de)
KR (1) KR20020038944A (de)
CN (1) CN1139579C (de)
AR (1) AR029400A1 (de)
AT (1) ATE256670T1 (de)
AU (1) AU757614B2 (de)
BR (1) BR0014851A (de)
CA (1) CA2385472A1 (de)
DE (1) DE60007347T2 (de)
DK (1) DK1226131T3 (de)
ES (1) ES2210033T3 (de)
HK (1) HK1044940A1 (de)
HU (1) HUP0203184A3 (de)
IL (1) IL148837A0 (de)
IT (1) IT1314191B1 (de)
MX (1) MXPA02003432A (de)
MY (1) MY120400A (de)
NO (1) NO20021803L (de)
NZ (1) NZ517884A (de)
PL (1) PL356990A1 (de)
PT (1) PT1226131E (de)
RU (1) RU2002113096A (de)
WO (1) WO2001029015A2 (de)
ZA (1) ZA200203942B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101277952B (zh) 2005-10-11 2011-09-28 弗·哈夫曼-拉罗切有限公司 异*唑衍生物
DE602006014185D1 (de) 2005-11-09 2010-06-17 Hoffmann La Roche 3-arylisoxazol-4-carbonylbenzofuranderivative
WO2007071598A1 (en) 2005-12-23 2007-06-28 F. Hoffmann-La Roche Ag Aryl-isoxazolo-4-yl-oxadiazole derivatives
EP1968973B1 (de) 2005-12-27 2011-10-05 F. Hoffmann-La Roche AG Aryl-isoxazol-4-yl-imidazol-derivate
EP1979350A1 (de) 2006-01-17 2008-10-15 F.Hoffmann-La Roche Ag Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridin zur behandlung von morbus alzheimer mittels gaba-rezeptoren
CN101454297B (zh) 2006-05-31 2012-10-31 弗·哈夫曼-拉罗切有限公司 芳基-4-乙炔基-异*唑衍生物
CN101965344B (zh) 2007-06-22 2013-03-06 弗·哈夫曼-拉罗切有限公司 异*唑-咪唑衍生物
US7943619B2 (en) 2007-12-04 2011-05-17 Hoffmann-La Roche Inc. Isoxazolo-pyridazine derivatives
US7902201B2 (en) 2007-12-04 2011-03-08 Hoffmann-La Roche Inc. Isoxazolo-pyrazine derivatives
AU2008333320B2 (en) 2007-12-04 2012-12-20 F. Hoffmann-La Roche Ag Isoxazolo-pyrazine derivatives
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
TW201033201A (en) 2009-02-19 2010-09-16 Hoffmann La Roche Isoxazole-isoxazole and isoxazole-isothiazole derivatives
US8389550B2 (en) 2009-02-25 2013-03-05 Hoffmann-La Roche Inc. Isoxazoles / O-pyridines with ethyl and ethenyl linker
US8222246B2 (en) 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
US8227461B2 (en) 2009-04-30 2012-07-24 Hoffmann-La Roche Inc. Isoxazoles
CA2760597C (en) 2009-05-05 2017-08-22 F. Hoffmann-La Roche Ag Isoxazole-pyridazine derivatives
SG175333A1 (en) 2009-05-05 2011-12-29 Hoffmann La Roche Isoxazole-pyrazole derivatives
WO2010127976A1 (en) 2009-05-05 2010-11-11 F. Hoffmann-La Roche Ag Isoxazole-pyridine derivatives
KR101354335B1 (ko) 2009-05-05 2014-02-19 에프. 호프만-라 로슈 아게 인지 장애의 치료에 사용되는 ｇａｂａ ａ 수용체 역 작용제로서의 아이속사졸-티아졸 유도체
KR101354416B1 (ko) 2009-05-07 2014-02-19 에프. 호프만-라 로슈 아게 감마-아미노부티르산 조절제로서 이속사졸-피리딘 유도체
US8785435B2 (en) 2011-10-20 2014-07-22 Hoffmann-La Roche Inc. Solid forms
CN113121540B (zh) * 2020-01-15 2024-01-26 鲁南制药集团股份有限公司 一种西格列汀游离碱的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen

Also Published As

Publication number Publication date
MY120400A (en) 2005-10-31
DE60007347D1 (de) 2004-01-29
NO20021803L (no) 2002-06-17
ES2210033T3 (es) 2004-07-01
EP1226131A2 (de) 2002-07-31
EP1226131B1 (de) 2003-12-17
CN1379767A (zh) 2002-11-13
WO2001029015A2 (en) 2001-04-26
HUP0203184A2 (hu) 2003-01-28
DK1226131T3 (da) 2004-04-19
RU2002113096A (ru) 2003-11-10
DE60007347T2 (de) 2004-09-02
NZ517884A (en) 2003-08-29
AU757614B2 (en) 2003-02-27
AR029400A1 (es) 2003-06-25
CN1139579C (zh) 2004-02-25
JP2003512362A (ja) 2003-04-02
ZA200203942B (en) 2003-01-02
KR20020038944A (ko) 2002-05-24
BR0014851A (pt) 2002-06-11
HK1044940A1 (zh) 2002-11-08
MXPA02003432A (es) 2002-08-20
WO2001029015A3 (en) 2001-11-01
AU2834701A (en) 2001-04-30
CA2385472A1 (en) 2001-04-26
ITMI992173A1 (it) 2001-04-18
IT1314191B1 (it) 2002-12-06
PT1226131E (pt) 2004-05-31
HUP0203184A3 (en) 2004-12-28
PL356990A1 (en) 2004-07-12
ITMI992173A0 (it) 1999-10-18
IL148837A0 (en) 2002-09-12
NO20021803D0 (no) 2002-04-17

Similar Documents

Publication Publication Date Title
DE60007347D1 (de) Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors
DE60120419D1 (de) 4-phenyl-pyridin-derivate verwendbar als neurokinin-1 rezeptor antagonisten
MA26929A1 (fr) N-oxydes en tant que promedicaments antagonistes recepteurs nk1 des derives de 4-phenyl-pyridine
ATE288898T1 (de) Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
DE60023167T2 (de) Pyrazol-derivate als cannabinoidrezeptor-antagonisten
DE69915888D1 (de) Sulfonamidverbindungen des hydroxydiphenylharnstoffs als il-8 rezeptorantagonisten
ATE235467T1 (de) Antagonisten des vitronectin-rezeptors
NO20030471D0 (no) Karboksamidforbindelser og deres anvendelse som antagonister for en 11CBY-reseptor
ATE322496T1 (de) 4-phenylpyridin-derivate als neurokinin-1- rezeptor-antagonisten
DE60028368D1 (de) Agonisten des peroxisom aktivator-responsiven rezeptors
NO20004503L (no) Vitronectin-reseptor-antagonister
NO20016053D0 (no) IL-8 reseptor-antagonister
ATE286022T1 (de) Naphthalin-carboxamide als tachykinin rezeptorantagonisten
NO994106L (no) Oksazolidiner som 5-HT2A-antagonister
DE60017110D1 (de) Biphenylderivate als neurokinin-1 antagonisten
DE50100358D1 (de) Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
NO20020644D0 (no) Nye integrinreseptor-antagonister
NO20016052L (no) IL-8-reseptor-antagonister
DE50008020D1 (de) Substituierte pyrrolidin-2,3,4-trion-derivate wirksam als nmda-rezeptor-antagonisten
DK1180028T3 (da) IL-8-receptorantagonister
DE60113525D1 (de) Propansäure-derivate als integrin-rezeptor-antagonisten
ATE284870T1 (de) Antagonisten des vitronectin-receptors
NO20015774L (no) IL-8 reseptorantagonister
NO20010620D0 (no) Vitronektinreseptor-antagonister
ATE286882T1 (de) Carboxy substituierte carboxamidderivative als tachykinin rezeptorantagoniste

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1226131

Country of ref document: EP

REN Ceased due to non-payment of the annual fee