ATE246684T1 - Substituierte 1,4-dihydroindeno(1,2-c)pyrazole als inhibitoren von tyrosinkinase - Google Patents
Substituierte 1,4-dihydroindeno(1,2-c)pyrazole als inhibitoren von tyrosinkinaseInfo
- Publication number
- ATE246684T1 ATE246684T1 AT00919742T AT00919742T ATE246684T1 AT E246684 T1 ATE246684 T1 AT E246684T1 AT 00919742 T AT00919742 T AT 00919742T AT 00919742 T AT00919742 T AT 00919742T AT E246684 T1 ATE246684 T1 AT E246684T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrazoles
- inhibitors
- dihydroindeno
- substituted
- tyrosine kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12796399P | 1999-04-06 | 1999-04-06 | |
PCT/US2000/008192 WO2000059901A1 (en) | 1999-04-06 | 2000-03-28 | Substituted 1,4-dihydroindeno[1,2-c]pyrazoles as inhibitors of tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE246684T1 true ATE246684T1 (de) | 2003-08-15 |
Family
ID=22432894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00919742T ATE246684T1 (de) | 1999-04-06 | 2000-03-28 | Substituierte 1,4-dihydroindeno(1,2-c)pyrazole als inhibitoren von tyrosinkinase |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1165544B1 (de) |
JP (1) | JP2002541150A (de) |
KR (1) | KR20020015034A (de) |
CN (1) | CN1368970A (de) |
AT (1) | ATE246684T1 (de) |
AU (1) | AU4037800A (de) |
BG (1) | BG106044A (de) |
BR (1) | BR0009561A (de) |
CA (1) | CA2368686A1 (de) |
CZ (1) | CZ20013580A3 (de) |
DE (1) | DE60004340T2 (de) |
DK (1) | DK1165544T3 (de) |
ES (1) | ES2207497T3 (de) |
HK (1) | HK1045500A1 (de) |
HU (1) | HUP0201514A3 (de) |
IL (1) | IL145564A0 (de) |
MX (1) | MXPA01010072A (de) |
NO (1) | NO20014864L (de) |
NZ (1) | NZ514269A (de) |
PL (1) | PL350891A1 (de) |
PT (1) | PT1165544E (de) |
SK (1) | SK14112001A3 (de) |
TR (1) | TR200103789T2 (de) |
WO (1) | WO2000059901A1 (de) |
ZA (1) | ZA200107838B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6462036B1 (en) | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
US6297238B1 (en) * | 1999-04-06 | 2001-10-02 | Basf Aktiengesellschaft | Therapeutic agents |
CA2460942A1 (en) | 2001-09-19 | 2003-03-27 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
US6849653B2 (en) | 2001-09-19 | 2005-02-01 | Pharmacia Corporation | Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation |
US20040127492A1 (en) * | 2002-02-19 | 2004-07-01 | Pharmacia Corporation | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
WO2003097609A1 (en) * | 2002-05-15 | 2003-11-27 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
MXPA05008688A (es) * | 2003-02-17 | 2005-10-05 | Pharmacia Italia Spa | Derivados tetraciclicos de pirazol como inhibidores de la cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden. |
JP2006519236A (ja) * | 2003-02-27 | 2006-08-24 | アボット・ラボラトリーズ | 複素環式キナーゼ阻害剤 |
US7320986B2 (en) | 2003-03-07 | 2008-01-22 | Abbott Labortories | Fused tri and tetra-cyclic pyrazole kinase inhibitors |
MXPA05009576A (es) * | 2003-03-07 | 2005-12-12 | Abbott Lab | Inhibidores de pirazol-quinasa triciclicos y tetraciclicos, fundidos. |
MXPA06010904A (es) | 2004-03-24 | 2007-06-11 | Abbott Lab | Inhibidores de pirazol cinasa triciclicos. |
JP5351254B2 (ja) * | 2008-05-23 | 2013-11-27 | ノバルティス アーゲー | キノキサリン−およびキノリン−カルボキシアミド誘導体 |
AT507953B1 (de) * | 2009-03-05 | 2011-02-15 | Apeptico Forschung & Entwicklung Gmbh | Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität |
US8853207B2 (en) | 2012-04-12 | 2014-10-07 | Development Center For Biotechnology | Heterocyclic pyrazole compounds, method for preparing the same and use thereof |
CN104610149B (zh) * | 2015-02-10 | 2017-04-05 | 山东大学 | 一种茚并吡唑类小分子微管蛋白抑制剂及其制备方法与应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
EP1021182A1 (de) * | 1997-10-06 | 2000-07-26 | Basf Aktiengesellschaft | Indeno[1,2-c] pyrazole derivativen zur hemmung der tyrosinekinase-wirksamkeit |
KR20010086005A (ko) * | 1998-11-06 | 2001-09-07 | 스타르크, 카르크 | 트리사이클릭 피라졸 유도체 |
-
2000
- 2000-03-28 SK SK1411-2001A patent/SK14112001A3/sk unknown
- 2000-03-28 KR KR1020017012696A patent/KR20020015034A/ko not_active Application Discontinuation
- 2000-03-28 CZ CZ20013580A patent/CZ20013580A3/cs unknown
- 2000-03-28 BR BR0009561-3A patent/BR0009561A/pt not_active IP Right Cessation
- 2000-03-28 AT AT00919742T patent/ATE246684T1/de not_active IP Right Cessation
- 2000-03-28 ES ES00919742T patent/ES2207497T3/es not_active Expired - Lifetime
- 2000-03-28 EP EP00919742A patent/EP1165544B1/de not_active Expired - Lifetime
- 2000-03-28 JP JP2000609412A patent/JP2002541150A/ja not_active Withdrawn
- 2000-03-28 CN CN00808326A patent/CN1368970A/zh active Pending
- 2000-03-28 NZ NZ514269A patent/NZ514269A/en unknown
- 2000-03-28 HU HU0201514A patent/HUP0201514A3/hu unknown
- 2000-03-28 DE DE60004340T patent/DE60004340T2/de not_active Expired - Fee Related
- 2000-03-28 CA CA002368686A patent/CA2368686A1/en not_active Abandoned
- 2000-03-28 AU AU40378/00A patent/AU4037800A/en not_active Abandoned
- 2000-03-28 PT PT00919742T patent/PT1165544E/pt unknown
- 2000-03-28 WO PCT/US2000/008192 patent/WO2000059901A1/en not_active Application Discontinuation
- 2000-03-28 DK DK00919742T patent/DK1165544T3/da active
- 2000-03-28 IL IL14556400A patent/IL145564A0/xx unknown
- 2000-03-28 PL PL00350891A patent/PL350891A1/xx not_active Application Discontinuation
- 2000-03-28 MX MXPA01010072A patent/MXPA01010072A/es unknown
- 2000-03-28 TR TR2001/03789T patent/TR200103789T2/xx unknown
-
2001
- 2001-09-21 ZA ZA200107838A patent/ZA200107838B/en unknown
- 2001-10-05 NO NO20014864A patent/NO20014864L/no not_active Application Discontinuation
- 2001-10-24 BG BG106044A patent/BG106044A/xx unknown
-
2002
- 2002-06-28 HK HK02104887.6A patent/HK1045500A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1165544A1 (de) | 2002-01-02 |
MXPA01010072A (es) | 2004-03-26 |
CN1368970A (zh) | 2002-09-11 |
EP1165544B1 (de) | 2003-08-06 |
DE60004340D1 (de) | 2003-09-11 |
HUP0201514A3 (en) | 2003-11-28 |
HUP0201514A2 (en) | 2002-08-28 |
AU4037800A (en) | 2000-10-23 |
HK1045500A1 (zh) | 2002-11-29 |
NO20014864L (no) | 2001-12-05 |
BR0009561A (pt) | 2002-04-16 |
PL350891A1 (en) | 2003-02-10 |
DE60004340T2 (de) | 2004-06-09 |
BG106044A (en) | 2002-05-31 |
PT1165544E (pt) | 2003-12-31 |
NO20014864D0 (no) | 2001-10-05 |
CA2368686A1 (en) | 2000-10-12 |
JP2002541150A (ja) | 2002-12-03 |
IL145564A0 (en) | 2002-06-30 |
DK1165544T3 (da) | 2003-12-01 |
TR200103789T2 (tr) | 2002-04-22 |
KR20020015034A (ko) | 2002-02-27 |
NZ514269A (en) | 2003-10-31 |
ZA200107838B (en) | 2003-03-24 |
ES2207497T3 (es) | 2004-06-01 |
CZ20013580A3 (cs) | 2002-03-13 |
SK14112001A3 (sk) | 2002-04-04 |
WO2000059901A1 (en) | 2000-10-12 |
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Legal Events
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UEP | Publication of translation of european patent specification |
Ref document number: 1165544 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |