ATE242635T1 - Squalamin in kombination mit anderen antikrebs- mittelen zur behandlung von tumoren - Google Patents
Squalamin in kombination mit anderen antikrebs- mittelen zur behandlung von tumorenInfo
- Publication number
- ATE242635T1 ATE242635T1 AT97921396T AT97921396T ATE242635T1 AT E242635 T1 ATE242635 T1 AT E242635T1 AT 97921396 T AT97921396 T AT 97921396T AT 97921396 T AT97921396 T AT 97921396T AT E242635 T1 ATE242635 T1 AT E242635T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- treatment procedure
- squalamine
- procedure
- cytotoxic chemical
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 13
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 229940127084 other anti-cancer agent Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 12
- UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 abstract 3
- UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 231100000433 cytotoxic Toxicity 0.000 abstract 3
- 230000001472 cytotoxic effect Effects 0.000 abstract 3
- 229950001248 squalamine Drugs 0.000 abstract 3
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 abstract 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- -1 BCNU) Chemical compound 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229940009456 adriamycin Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 238000011269 treatment regimen Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1638796P | 1996-04-26 | 1996-04-26 | |
| PCT/US1997/007011 WO1997040835A1 (en) | 1996-04-26 | 1997-04-25 | Treatment of carcinomas using squalamine in combination with other anti-cancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE242635T1 true ATE242635T1 (de) | 2003-06-15 |
Family
ID=21776862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97921396T ATE242635T1 (de) | 1996-04-26 | 1997-04-25 | Squalamin in kombination mit anderen antikrebs- mittelen zur behandlung von tumoren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6147060A (https=) |
| EP (1) | EP0910382B1 (https=) |
| JP (1) | JP2000510460A (https=) |
| AT (1) | ATE242635T1 (https=) |
| AU (1) | AU735884B2 (https=) |
| CA (1) | CA2252584C (https=) |
| DE (1) | DE69722793T2 (https=) |
| DK (1) | DK0910382T3 (https=) |
| ES (1) | ES2201296T3 (https=) |
| PT (1) | PT910382E (https=) |
| WO (1) | WO1997040835A1 (https=) |
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| US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| IT1229570B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
| IT1229569B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
| JPH07116215B2 (ja) * | 1989-04-19 | 1995-12-13 | エスエス製薬株式会社 | 新規なステロイド化合物 |
| PT93847A (pt) * | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5004737A (en) * | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
| EP0466315A3 (en) * | 1990-05-30 | 1992-07-01 | Larrian Gillespie | Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation |
| DE69132048T2 (de) * | 1990-06-11 | 2000-07-13 | Alcon Laboratories Inc.(N.D.Ges.D.Staates Delaware), Forth Worth | Verwendung von Steroiden zur Inhibierung von Angiogenesis |
| US5250524A (en) * | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
| US5192756A (en) * | 1992-03-18 | 1993-03-09 | The Children's Hospital Of Pennsylvania | Aminosterol antibiotic |
| EP0647133A4 (en) * | 1992-06-12 | 1997-10-29 | Affymax Tech Nv | COMPOSITIONS AND METHODS FOR IMPROVED DRUG DELIVERY. |
| AU6392894A (en) * | 1993-02-26 | 1994-09-14 | Magainin Pharmaceuticals, Inc. | Chemical synthesis of squalamine |
| WO1994020520A1 (en) * | 1993-03-10 | 1994-09-15 | Magainin Pharmaceuticals Inc. | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
| ES2164110T3 (es) * | 1994-03-10 | 2002-02-16 | Magainin Pharma | Usos farmaceuticos de derivados de esteroides. |
| US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
| AU723663C (en) * | 1995-06-07 | 2001-11-01 | Magainin Pharmaceuticals, Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds |
-
1997
- 1997-04-25 PT PT97921396T patent/PT910382E/pt unknown
- 1997-04-25 WO PCT/US1997/007011 patent/WO1997040835A1/en not_active Ceased
- 1997-04-25 DK DK97921396T patent/DK0910382T3/da active
- 1997-04-25 AT AT97921396T patent/ATE242635T1/de not_active IP Right Cessation
- 1997-04-25 DE DE69722793T patent/DE69722793T2/de not_active Expired - Lifetime
- 1997-04-25 US US08/840,706 patent/US6147060A/en not_active Expired - Lifetime
- 1997-04-25 ES ES97921396T patent/ES2201296T3/es not_active Expired - Lifetime
- 1997-04-25 AU AU27441/97A patent/AU735884B2/en not_active Ceased
- 1997-04-25 EP EP97921396A patent/EP0910382B1/en not_active Expired - Lifetime
- 1997-04-25 JP JP09539076A patent/JP2000510460A/ja active Pending
- 1997-04-25 CA CA002252584A patent/CA2252584C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997040835A1 (en) | 1997-11-06 |
| EP0910382B1 (en) | 2003-06-11 |
| ES2201296T3 (es) | 2004-03-16 |
| DE69722793D1 (de) | 2003-07-17 |
| AU735884B2 (en) | 2001-07-19 |
| DK0910382T3 (da) | 2003-10-06 |
| AU2744197A (en) | 1997-11-19 |
| EP0910382A1 (en) | 1999-04-28 |
| CA2252584C (en) | 2008-06-10 |
| PT910382E (pt) | 2003-10-31 |
| JP2000510460A (ja) | 2000-08-15 |
| US6147060A (en) | 2000-11-14 |
| DE69722793T2 (de) | 2004-05-19 |
| CA2252584A1 (en) | 1997-11-06 |
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