ATE241140T1 - Verfahren zur herstellung einer probe in einer scan-kapillare für immunofluoreszenzuntersuchung - Google Patents
Verfahren zur herstellung einer probe in einer scan-kapillare für immunofluoreszenzuntersuchungInfo
- Publication number
- ATE241140T1 ATE241140T1 AT95935134T AT95935134T ATE241140T1 AT E241140 T1 ATE241140 T1 AT E241140T1 AT 95935134 T AT95935134 T AT 95935134T AT 95935134 T AT95935134 T AT 95935134T AT E241140 T1 ATE241140 T1 AT E241140T1
- Authority
- AT
- Austria
- Prior art keywords
- target components
- sample
- fluorescent
- whole blood
- complex
- Prior art date
Links
- 238000010166 immunofluorescence Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000004369 blood Anatomy 0.000 abstract 4
- 239000008280 blood Substances 0.000 abstract 4
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 238000005534 hematocrit Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000005464 sample preparation method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/328,241 US5585246A (en) | 1993-02-17 | 1994-10-24 | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
PCT/US1995/012305 WO1996012963A1 (en) | 1994-10-24 | 1995-09-22 | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE241140T1 true ATE241140T1 (de) | 2003-06-15 |
Family
ID=23280142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95935134T ATE241140T1 (de) | 1994-10-24 | 1995-09-22 | Verfahren zur herstellung einer probe in einer scan-kapillare für immunofluoreszenzuntersuchung |
Country Status (8)
Country | Link |
---|---|
US (2) | US5585246A (de) |
EP (1) | EP0788604B1 (de) |
JP (1) | JP3623513B2 (de) |
AT (1) | ATE241140T1 (de) |
AU (1) | AU704473B2 (de) |
CA (1) | CA2203098A1 (de) |
DE (1) | DE69530855T2 (de) |
WO (1) | WO1996012963A1 (de) |
Families Citing this family (65)
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US5585246A (en) * | 1993-02-17 | 1996-12-17 | Biometric Imaging, Inc. | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
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US6235536B1 (en) * | 1998-03-07 | 2001-05-22 | Robert A. Levine | Analysis of quiescent anticoagulated whole blood samples |
US6350613B1 (en) * | 1998-03-07 | 2002-02-26 | Belton Dickinson & Co. | Determination of white blood cell differential and reticulocyte counts |
US5948686A (en) * | 1998-03-07 | 1999-09-07 | Robert A. Leuine | Method for performing blood cell counts |
US6127184A (en) | 1998-03-07 | 2000-10-03 | Robert A. Levine | Calibration of a whole blood sample analyzer |
US6200766B1 (en) | 1998-12-03 | 2001-03-13 | Becton Dickinson And Company | Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells |
US6423505B1 (en) * | 1998-12-03 | 2002-07-23 | Becton Dickinson And Company | Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells |
US20030235920A1 (en) * | 2000-02-28 | 2003-12-25 | James Wyatt | Diagnostic device and method |
US6937330B2 (en) | 1999-04-23 | 2005-08-30 | Ppd Biomarker Discovery Sciences, Llc | Disposable optical cuvette cartridge with low fluorescence material |
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SE530750C2 (sv) * | 2006-07-19 | 2008-09-02 | Hemocue Ab | En mätapparat, en metod och ett datorprogram |
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WO2008132755A1 (en) * | 2007-04-27 | 2008-11-06 | Mahatma Gandhi Mission's University Of Health Sciences | A test kit for estimating cd4 + /cd8 + t-cells in a human blood sample |
CN101520401B (zh) * | 2008-02-29 | 2012-08-29 | 鸿富锦精密工业(深圳)有限公司 | 粒子统计方法及装置 |
CN101566630A (zh) * | 2009-02-19 | 2009-10-28 | 浙江海洋学院 | 状黄姑鱼细菌性烂鳃病的预警方法 |
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US20140152801A1 (en) | 2009-10-28 | 2014-06-05 | Alentic Microscience Inc. | Detecting and Using Light Representative of a Sample |
US9075225B2 (en) | 2009-10-28 | 2015-07-07 | Alentic Microscience Inc. | Microscopy imaging |
WO2011075667A2 (en) | 2009-12-18 | 2011-06-23 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge |
EP2526114B1 (de) * | 2010-01-22 | 2014-06-18 | Boehringer Ingelheim International GmbH | Chromatographisches verfahren zur aufreinigung von fc enthaltenden proteinen |
US10114020B2 (en) | 2010-10-11 | 2018-10-30 | Mbio Diagnostics, Inc. | System and device for analyzing a fluidic sample |
WO2012059786A1 (en) * | 2010-11-03 | 2012-05-10 | Reametrix Inc. | Measurement system for fluorescent detection, and method therefor |
EP2658653B1 (de) | 2010-12-30 | 2015-03-04 | Abbott Point Of Care, Inc. | Kassette zur analyse biologischer proben mit probebehandlungsteil und analysekammerteil |
EP2748618A1 (de) | 2011-08-24 | 2014-07-02 | Abbott Point of Care Inc. | Kartusche zur analyse einer biologischen flüssigkeit |
EP2780707B1 (de) | 2012-05-02 | 2016-02-24 | Charles River Laboratories, Inc. | Nachweisverfahren für lebenfähige zellen in einer zellprobe |
WO2013166336A1 (en) | 2012-05-02 | 2013-11-07 | Charles River Laboratories, Inc. | Viability staining method |
JP6240162B2 (ja) | 2012-05-02 | 2017-11-29 | チャールズ リバー ラボラトリーズ, インコーポレイテッド | 細胞収集システムおよびその使用 |
WO2014018805A2 (en) | 2012-07-25 | 2014-01-30 | Theranos,Inc. | Image analysis and measurement of biological samples |
US9739714B2 (en) | 2012-10-29 | 2017-08-22 | Mbio Diagnostics, Inc. | Particle identification system, cartridge and associated methods |
US10502666B2 (en) | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
BR112015020098B1 (pt) | 2013-03-15 | 2020-10-27 | Iris International, Inc. | composição de agente de contraste de partículas para colorir uma amostra de fluido sanguíneo e método para tratar partículas de uma amostra de fluido sanguíneo |
KR102053487B1 (ko) | 2013-03-15 | 2019-12-06 | 아이리스 인터내셔널 인크. | 혈액 샘플에서의 입자 분석을 위한 시스 유체 시스템 및 방법 |
CA3080335C (en) | 2013-06-26 | 2023-06-13 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
JP6383216B2 (ja) * | 2014-08-08 | 2018-08-29 | シスメックス株式会社 | 血液分析方法、血液分析装置およびプログラム |
US10768105B1 (en) | 2016-07-29 | 2020-09-08 | Labrador Diagnostics Llc | Image analysis and measurement of biological samples |
US20210181085A1 (en) * | 2017-10-26 | 2021-06-17 | Essenlix Corporation | Rapid measurement of platelets |
US10914913B2 (en) | 2018-03-30 | 2021-02-09 | Idexx Laboratories, Inc. | Flow cytometer, laser optics assembly thereof, and methods of assembling the same |
AU2021293085A1 (en) | 2020-06-17 | 2023-02-16 | Idexx Laboratories Inc. | Flow cytometer and laser optics assembly thereof |
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US5585246A (en) * | 1993-02-17 | 1996-12-17 | Biometric Imaging, Inc. | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
-
1994
- 1994-10-24 US US08/328,241 patent/US5585246A/en not_active Expired - Lifetime
-
1995
- 1995-09-22 CA CA002203098A patent/CA2203098A1/en not_active Abandoned
- 1995-09-22 JP JP51391796A patent/JP3623513B2/ja not_active Expired - Lifetime
- 1995-09-22 DE DE69530855T patent/DE69530855T2/de not_active Expired - Lifetime
- 1995-09-22 EP EP95935134A patent/EP0788604B1/de not_active Expired - Lifetime
- 1995-09-22 AU AU37268/95A patent/AU704473B2/en not_active Ceased
- 1995-09-22 WO PCT/US1995/012305 patent/WO1996012963A1/en active IP Right Grant
- 1995-09-22 AT AT95935134T patent/ATE241140T1/de not_active IP Right Cessation
-
1996
- 1996-10-28 US US08/739,131 patent/US5932428A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU3726895A (en) | 1996-05-15 |
US5932428A (en) | 1999-08-03 |
EP0788604B1 (de) | 2003-05-21 |
JP2000510572A (ja) | 2000-08-15 |
WO1996012963A1 (en) | 1996-05-02 |
DE69530855D1 (de) | 2003-06-26 |
DE69530855T2 (de) | 2004-02-26 |
EP0788604A1 (de) | 1997-08-13 |
US5585246A (en) | 1996-12-17 |
AU704473B2 (en) | 1999-04-22 |
JP3623513B2 (ja) | 2005-02-23 |
EP0788604A4 (de) | 1998-12-30 |
CA2203098A1 (en) | 1996-05-02 |
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