ATE21173T1 - Methode zur fluoreszenz-spektroskopischen bestimmung von biologisch aktiven substanzen. - Google Patents

Methode zur fluoreszenz-spektroskopischen bestimmung von biologisch aktiven substanzen.

Info

Publication number
ATE21173T1
ATE21173T1 AT82850077T AT82850077T ATE21173T1 AT E21173 T1 ATE21173 T1 AT E21173T1 AT 82850077 T AT82850077 T AT 82850077T AT 82850077 T AT82850077 T AT 82850077T AT E21173 T1 ATE21173 T1 AT E21173T1
Authority
AT
Austria
Prior art keywords
fluorescence
lantanide
chelate
biologically active
active substances
Prior art date
Application number
AT82850077T
Other languages
English (en)
Inventor
Ilkka Hemmilae
Salifu Dakubu
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Application granted granted Critical
Publication of ATE21173T1 publication Critical patent/ATE21173T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT82850077T 1981-04-30 1982-04-08 Methode zur fluoreszenz-spektroskopischen bestimmung von biologisch aktiven substanzen. ATE21173T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8102753A SE425439B (sv) 1981-04-30 1981-04-30 Immunologisk analys med lantanidkelatkomplex som markor
EP82850077A EP0064484B1 (de) 1981-04-30 1982-04-08 Methode zur fluoreszenz-spektroskopischen Bestimmung von biologisch aktiven Substanzen

Publications (1)

Publication Number Publication Date
ATE21173T1 true ATE21173T1 (de) 1986-08-15

Family

ID=20343715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82850077T ATE21173T1 (de) 1981-04-30 1982-04-08 Methode zur fluoreszenz-spektroskopischen bestimmung von biologisch aktiven substanzen.

Country Status (6)

Country Link
US (1) US4565790A (de)
EP (2) EP0159066A1 (de)
JP (1) JPS57186170A (de)
AT (1) ATE21173T1 (de)
DE (1) DE3272260D1 (de)
SE (1) SE425439B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4629693A (en) * 1984-03-27 1986-12-16 Syntex (U.S.A.) Inc. Sensitivity in fluorescence assays in icteric samples
US5830769A (en) * 1985-03-18 1998-11-03 Wieder; Irwin Homogeneous fluorassay methods employing fluorescent background rejection and water-soluble rare earth metal chelates
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
IT1186733B (it) * 1985-06-05 1987-12-16 Eniricerche Spa Composti tripeptidici ad azione ipotensiva
US5155216A (en) * 1985-08-15 1992-10-13 Amoco Corporation Nucleic acids labeled with a chemiluminescent acridine ester
EP0244471A4 (de) * 1985-10-24 1988-01-28 Siska Diagnostics Inc Mit lanthanidenchelat markierte nukleinsäureproben.
GB8601646D0 (en) * 1986-01-23 1986-02-26 Davidson R S Binding assay & reagent
US5585279A (en) * 1986-01-23 1996-12-17 Davidson; Robert S. Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium
US4727024A (en) * 1986-05-12 1988-02-23 Martin Koocher Binding assays involving formation and detection of light scattering crystals
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
DE3789430T2 (de) 1986-06-17 1994-10-27 Baxter Diagnostics Inc Homogenes fluortestverfahren mit abstoss des fluorzenten hintergrundes.
GB8622855D0 (en) * 1986-09-23 1986-10-29 Ekins R P Determining biological substance
SE8703682L (sv) * 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
US4978625A (en) * 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
AU2714988A (en) * 1987-10-23 1989-06-01 Siska Diagnostics, Inc. Lanthanide chelate-tagged nucleic acid probes
EP0493745A1 (de) * 1990-12-21 1992-07-08 Dojindo Laboratories Fluoreszierende Verbindung, Komplex, Reagenz und spezifische Bindungtest
FI88545C (fi) * 1991-03-12 1993-05-25 Jouko Kankare Bestaemningsmetod
US5792330A (en) * 1995-05-31 1998-08-11 Board Of Regents, The University Of Texas System Lanthanide metal cations for concurrent detection and separation in capillary electrophoresis
JP3538277B2 (ja) 1996-03-08 2004-06-14 和子 松本 免疫測定用標識試薬及びそれに用いる蛍光性化合物及び錯体、及びそれらを用いる生物物質の免疫測定法
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US6030840A (en) * 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
US6838292B1 (en) 1999-04-19 2005-01-04 Alion Science And Technology Corporation Detection of biological warfare agents
WO2001036663A2 (en) 1999-11-15 2001-05-25 Chemclean Corporation Bio-burden visualization system
JP4545337B2 (ja) * 2001-03-23 2010-09-15 オリンパス株式会社 顕微鏡
AU2002322351A1 (en) * 2001-06-28 2003-03-03 Ia, Inc. Fiber-optic sensor array
JP4117248B2 (ja) * 2001-10-10 2008-07-16 株式会社日立ハイテクノロジーズ 発光性化合物及びそれを用いた標識試薬
US7211440B2 (en) 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
WO2006039505A2 (en) * 2004-09-30 2006-04-13 Molecular Devices Corporation Luminescent lanthanide complexes
US20060166376A1 (en) * 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
US7482444B2 (en) * 2006-03-13 2009-01-27 Wallac Oy Terminating substrates for DNA polymerases
US8778614B2 (en) 2010-08-24 2014-07-15 Enzo Life Sciences, Inc. Assays for detecting modified compounds
CN103969432B (zh) * 2014-03-27 2016-02-17 中国科学院福建物质结构研究所 一种稀土纳米材料溶解增强时间分辨荧光免疫分析方法
US9834808B2 (en) 2016-01-21 2017-12-05 SeLux Diagnostics, Inc. Methods for rapid antibiotic susceptibility testing
CN109072280B (zh) 2016-01-21 2022-10-14 赛录科试诊断公司 用于快速抗微生物剂敏感性测试的方法
CA3048213A1 (en) 2016-12-23 2018-06-28 Eric Stern Methods for improved rapid antimicrobial susceptibility testing
US11845976B2 (en) 2019-08-27 2023-12-19 SeLux Diagnostics, Inc. Systems and methods for performing antimicrobial susceptibility testing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
US4341957A (en) * 1975-11-26 1982-07-27 Analytical Radiation Corporation Fluorescent antibody composition for immunofluorometric assay
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
US4283382A (en) * 1977-12-28 1981-08-11 Eastman Kodak Company Fluorescent labels comprising rare earth chelates
US4259313A (en) * 1978-10-18 1981-03-31 Eastman Kodak Company Fluorescent labels

Also Published As

Publication number Publication date
JPS57186170A (en) 1982-11-16
SE425439B (sv) 1982-09-27
EP0064484A2 (de) 1982-11-10
EP0064484B1 (de) 1986-07-30
EP0064484A3 (en) 1983-01-19
US4565790A (en) 1986-01-21
EP0159066A1 (de) 1985-10-23
JPH049263B2 (de) 1992-02-19
DE3272260D1 (en) 1986-09-04

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Legal Events

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UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time