ATE233243T1 - Salze von chinolinderivaten als nk3 antagonisten - Google Patents
Salze von chinolinderivaten als nk3 antagonistenInfo
- Publication number
- ATE233243T1 ATE233243T1 AT96941026T AT96941026T ATE233243T1 AT E233243 T1 ATE233243 T1 AT E233243T1 AT 96941026 T AT96941026 T AT 96941026T AT 96941026 T AT96941026 T AT 96941026T AT E233243 T1 ATE233243 T1 AT E233243T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonists
- salts
- quinoline derivatives
- quinoline
- derivatives
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9524137.8A GB9524137D0 (en) | 1995-11-24 | 1995-11-24 | Novel compounds |
| PCT/EP1996/005210 WO1997019928A1 (en) | 1995-11-24 | 1996-11-22 | Salts of quinoline derivatives as nk3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233243T1 true ATE233243T1 (de) | 2003-03-15 |
Family
ID=10784449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96941026T ATE233243T1 (de) | 1995-11-24 | 1996-11-22 | Salze von chinolinderivaten als nk3 antagonisten |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6355654B1 (de) |
| EP (1) | EP0876348B1 (de) |
| JP (1) | JP4377454B2 (de) |
| KR (1) | KR19990071599A (de) |
| CN (1) | CN1207728A (de) |
| AR (1) | AR004970A1 (de) |
| AT (1) | ATE233243T1 (de) |
| AU (1) | AU722451B2 (de) |
| BR (1) | BR9611729A (de) |
| CA (1) | CA2238312A1 (de) |
| CZ (1) | CZ158198A3 (de) |
| DE (1) | DE69626416T2 (de) |
| ES (1) | ES2192621T3 (de) |
| GB (1) | GB9524137D0 (de) |
| HU (1) | HUP9903584A3 (de) |
| IL (1) | IL124352A0 (de) |
| MX (1) | MX9804106A (de) |
| NO (1) | NO310866B1 (de) |
| NZ (1) | NZ323389A (de) |
| PL (1) | PL326927A1 (de) |
| TR (1) | TR199800925T2 (de) |
| WO (1) | WO1997019928A1 (de) |
| ZA (1) | ZA969812B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| US7037922B1 (en) | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| WO2000058313A1 (en) | 1999-03-29 | 2000-10-05 | Neurogen Corporation | 4-substituted quinoline derivatives as gaba receptor ligands |
| AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| RU2229475C1 (ru) * | 2003-03-06 | 2004-05-27 | ООО "Исследовательский институт химического разнообразия | 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека |
| AU2006253054A1 (en) * | 2005-06-03 | 2006-12-07 | Astrazeneca Ab | Quinoline derivatives as NK3 anatgonists |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| WO2007016609A2 (en) * | 2005-08-02 | 2007-02-08 | Smithkline Beecham Corporation | Method for the synthesis of quinoliνe derivatives |
| EP1915363A1 (de) * | 2005-08-11 | 2008-04-30 | AstraZeneca AB | Oxopyridylchinolinamide als modulatoren des nk3-rezeptors |
| AR057130A1 (es) * | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| US20080234269A1 (en) * | 2005-09-21 | 2008-09-25 | Astrazeneca Ab | N-Oxo-Heterocycle and N-Oxo-Alkyl Quinoline-4-Carboxamides as Nk-3 Receptor Ligands |
| TW201018662A (en) | 2005-12-12 | 2010-05-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| WO2007086799A1 (en) * | 2006-01-27 | 2007-08-02 | Astrazeneca Ab | Amide substituted quinolines |
| FR2979173B1 (fr) * | 2011-08-19 | 2013-08-16 | St Microelectronics Grenoble 2 | Commutateur analogique basse tension |
| MX344308B (es) * | 2011-11-03 | 2016-12-13 | Merck Sharp & Dohme | Derivados de quinolina carboxamida y quinolina carbonitrilo como moduladores alostericos negativos de mglur2, composiciones y su uso. |
| WO2014170648A1 (en) | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos) |
| WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO114445B1 (ro) * | 1994-05-27 | 1999-04-30 | Smithkline Beecham S.P.A. | Derivaţi de chinolină antagonişti ai receptorului nk3 tachichinină,procedeu de preparare,compoziţii farmaceutice pe baza acestora şi metodă de tratament |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1995
- 1995-11-24 GB GBGB9524137.8A patent/GB9524137D0/en active Pending
-
1996
- 1996-11-21 AR ARP960105281A patent/AR004970A1/es unknown
- 1996-11-22 PL PL96326927A patent/PL326927A1/xx unknown
- 1996-11-22 WO PCT/EP1996/005210 patent/WO1997019928A1/en not_active Ceased
- 1996-11-22 IL IL12435296A patent/IL124352A0/xx unknown
- 1996-11-22 CA CA002238312A patent/CA2238312A1/en not_active Abandoned
- 1996-11-22 EP EP96941026A patent/EP0876348B1/de not_active Expired - Lifetime
- 1996-11-22 NZ NZ323389A patent/NZ323389A/en unknown
- 1996-11-22 TR TR1998/00925T patent/TR199800925T2/xx unknown
- 1996-11-22 US US09/077,152 patent/US6355654B1/en not_active Expired - Fee Related
- 1996-11-22 ZA ZA9609812A patent/ZA969812B/xx unknown
- 1996-11-22 JP JP52016097A patent/JP4377454B2/ja not_active Expired - Fee Related
- 1996-11-22 AU AU10319/97A patent/AU722451B2/en not_active Ceased
- 1996-11-22 KR KR1019980703875A patent/KR19990071599A/ko not_active Ceased
- 1996-11-22 HU HU9903584A patent/HUP9903584A3/hu unknown
- 1996-11-22 BR BR9611729A patent/BR9611729A/pt unknown
- 1996-11-22 CZ CZ981581A patent/CZ158198A3/cs unknown
- 1996-11-22 ES ES96941026T patent/ES2192621T3/es not_active Expired - Lifetime
- 1996-11-22 DE DE69626416T patent/DE69626416T2/de not_active Expired - Lifetime
- 1996-11-22 CN CN96199611A patent/CN1207728A/zh active Pending
- 1996-11-22 AT AT96941026T patent/ATE233243T1/de not_active IP Right Cessation
-
1998
- 1998-05-22 NO NO19982332A patent/NO310866B1/no not_active IP Right Cessation
- 1998-05-22 MX MX9804106A patent/MX9804106A/es unknown
-
2001
- 2001-11-06 US US09/994,076 patent/US6432977B1/en not_active Expired - Fee Related
-
2002
- 2002-06-12 US US10/167,881 patent/US20020156097A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4377454B2 (ja) | 2009-12-02 |
| DE69626416T2 (de) | 2003-12-24 |
| DE69626416D1 (de) | 2003-04-03 |
| IL124352A0 (en) | 1998-12-06 |
| US20020077335A1 (en) | 2002-06-20 |
| KR19990071599A (ko) | 1999-09-27 |
| US20020156097A1 (en) | 2002-10-24 |
| ES2192621T3 (es) | 2003-10-16 |
| HUP9903584A2 (hu) | 2000-02-28 |
| US6355654B1 (en) | 2002-03-12 |
| TR199800925T2 (xx) | 2001-05-21 |
| HUP9903584A3 (en) | 2001-10-29 |
| JP2000500770A (ja) | 2000-01-25 |
| WO1997019928A1 (en) | 1997-06-05 |
| PL326927A1 (en) | 1998-11-09 |
| NO310866B1 (no) | 2001-09-10 |
| EP0876348B1 (de) | 2003-02-26 |
| US6432977B1 (en) | 2002-08-13 |
| BR9611729A (pt) | 1999-04-06 |
| AU722451B2 (en) | 2000-08-03 |
| NO982332L (no) | 1998-05-22 |
| CA2238312A1 (en) | 1997-06-05 |
| NO982332D0 (no) | 1998-05-22 |
| AR004970A1 (es) | 1999-04-07 |
| ZA969812B (en) | 1998-05-22 |
| CZ158198A3 (cs) | 1998-10-14 |
| AU1031997A (en) | 1997-06-19 |
| EP0876348A1 (de) | 1998-11-11 |
| MX9804106A (es) | 1998-09-30 |
| NZ323389A (en) | 2000-02-28 |
| CN1207728A (zh) | 1999-02-10 |
| GB9524137D0 (en) | 1996-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE246677T1 (de) | Chinolinderivate als tachykinin nk3 rezeptor antagonisten | |
| DE69628334D1 (de) | Chinolin derivate als nk3 antagoniste | |
| DE69304243D1 (de) | Chinolin-Verbindungen als Angiotensin-II-Antagoniste | |
| FI944734L (fi) | Kinoliinijohdannaiset leukotrieeniantagonisteina | |
| DE69431604D1 (de) | Benzofuranderivate als tachykininantagonisten | |
| ATE289994T1 (de) | Chinolin-derivate | |
| DE69626416D1 (de) | Salze von chinolinderivaten als nk3 antagonisten | |
| ATE187172T1 (de) | Chinolin-2-on derivate als serotonin antagonisten | |
| FI960727L (fi) | Neurokiniiniantagonisteina käyttökelpoiset heterosyklit | |
| ATE201199T1 (de) | Benzo(g)chinolinderivate | |
| NO974605D0 (no) | Nye heterosykliske forbindelser | |
| DE69617995D1 (de) | Indolalkylderivate von benzodioxanmenthylamin als 5-ht1a rezeptor liganden | |
| FI950089A7 (fi) | Dioksosyklobuteenijohdannaiset angiotensiini-II-antagonisteina | |
| FI962639A7 (fi) | Diaryyli-5,6-fuusioituneita heterosyklisiä happoja leukotrieeniantagon isteina | |
| ATE325118T1 (de) | Piperazinoderivate als neurokinin-antagonisten | |
| BR9205939A (pt) | Derivados de 4-aril-3-(heteroalilureído)quinolina | |
| DE69328701D1 (de) | Diazabicycloderivate als 5-HT3-Antagonisten | |
| DE69617010D1 (de) | Isazole derivate als fibrinogen-rezeptor-antagonisten | |
| NO981216D0 (no) | Nye heterosykliske forbindelser | |
| DK0946548T3 (da) | Nye heterocykliske substituerede pyrrolidinamidderivater | |
| KR950700884A (ko) | 루코트리엔 길항제로서의 퀴놀린 유도체(Quinoline derivatives as leukotriene antagonists) | |
| DE69621706D1 (de) | Verwendung von Piperazinverbindungen als narkotische Antagonisten | |
| FI970143A7 (fi) | Kinoliinijohdannaiset leukotrieeniantagonisteina | |
| DK0940391T3 (da) | Quinolinderivater som tachykinin-NK3-receptor-antagonister |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |