DE69328701D1 - Diazabicycloderivate als 5-HT3-Antagonisten - Google Patents

Diazabicycloderivate als 5-HT3-Antagonisten

Info

Publication number
DE69328701D1
DE69328701D1 DE69328701T DE69328701T DE69328701D1 DE 69328701 D1 DE69328701 D1 DE 69328701D1 DE 69328701 T DE69328701 T DE 69328701T DE 69328701 T DE69328701 T DE 69328701T DE 69328701 D1 DE69328701 D1 DE 69328701D1
Authority
DE
Germany
Prior art keywords
antagonists
diazabicyclo derivatives
diazabicyclo
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69328701T
Other languages
English (en)
Other versions
DE69328701T2 (de
Inventor
Hiroaki Satoh
Haruhiko Kikuchi
Kazuhiko Yamada
Ruta Fukutomi
Masashi Suzuki
Koichiro Hagihara
Toru Hayakawa
Takeo Arai
Setsuko Mino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Publication of DE69328701D1 publication Critical patent/DE69328701D1/de
Application granted granted Critical
Publication of DE69328701T2 publication Critical patent/DE69328701T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69328701T 1992-01-31 1993-01-29 Diazabicycloderivate als 5-HT3-Antagonisten Expired - Lifetime DE69328701T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1617292 1992-01-31

Publications (2)

Publication Number Publication Date
DE69328701D1 true DE69328701D1 (de) 2000-06-29
DE69328701T2 DE69328701T2 (de) 2000-11-02

Family

ID=11909094

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328701T Expired - Lifetime DE69328701T2 (de) 1992-01-31 1993-01-29 Diazabicycloderivate als 5-HT3-Antagonisten

Country Status (8)

Country Link
US (1) US5344831A (de)
EP (1) EP0558923B1 (de)
KR (1) KR100251604B1 (de)
BR (1) BR9300390A (de)
CA (1) CA2088454C (de)
DE (1) DE69328701T2 (de)
ES (1) ES2147733T3 (de)
TW (1) TW240228B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013503A1 (en) * 1993-01-06 1996-05-09 Neurogen Corporation Certain tricyclic substituted diazabicyclo[3.2.1] octane derivatives
GEP20043368B (en) * 1998-07-17 2004-04-13 Agouron Pharma Compounds, Compositions, and Methods For Stimulating Neuronal Growth and Elongation
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
EP1581503A4 (de) * 2002-11-08 2007-07-25 Merck & Co Inc Ophthalmische zusammensetzungen zur behandlung der okularen hypertonie
BRPI0907963A2 (pt) * 2008-02-29 2015-08-04 Pfizer Derivados de indazola
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
JP7055017B2 (ja) 2014-09-29 2022-04-15 武田薬品工業株式会社 結晶形の１－（１－メチル－１ｈ－ピラゾール－４－イル）－ｎ－（（１ｒ，５ｓ，７ｓ）－９－メチル－３－オキサ－９－アザビシクロ［３．３．１］ノナン－７－イル）－１ｈ－インドール－３－カルボキサミド

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0498466B1 (de) * 1985-04-27 2002-07-24 F. Hoffmann-La Roche Ag Derivate von Indazole-3-carboxamide und -3-carboxylsäure
GB8607163D0 (en) * 1986-03-22 1986-04-30 Beecham Group Plc Chemical compound
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
US5256656A (en) * 1990-07-31 1993-10-26 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
GB9020927D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Pharmaceuticals
US5224487A (en) * 1991-07-22 1993-07-06 Healthscan Products, Inc. Portable peak flow meter
GB9121170D0 (en) * 1991-10-05 1991-11-20 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
KR100251604B1 (ko) 2000-09-01
ES2147733T3 (es) 2000-10-01
KR930016420A (ko) 1993-08-26
US5344831A (en) 1994-09-06
BR9300390A (pt) 1993-08-03
TW240228B (de) 1995-02-11
EP0558923A1 (de) 1993-09-08
DE69328701T2 (de) 2000-11-02
EP0558923B1 (de) 2000-05-24
CA2088454A1 (en) 1993-08-01
CA2088454C (en) 2003-08-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NISSHIN SEIFUN GROUP INC., TOKIO/TOKYO, JP

R071 Expiry of right

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