HUP9903584A2 - Kinolinszármazékok NK3 antagonistákként alkalmazható sói - Google Patents

Kinolinszármazékok NK3 antagonistákként alkalmazható sói

Info

Publication number
HUP9903584A2
HUP9903584A2 HU9903584A HUP9903584A HUP9903584A2 HU P9903584 A2 HUP9903584 A2 HU P9903584A2 HU 9903584 A HU9903584 A HU 9903584A HU P9903584 A HUP9903584 A HU P9903584A HU P9903584 A2 HUP9903584 A2 HU P9903584A2
Authority
HU
Hungary
Prior art keywords
alkyl
optionally substituted
ring
aminoalkyl
alkoxycarbonyl
Prior art date
Application number
HU9903584A
Other languages
English (en)
Inventor
Carlo Farina
Giuseppe Arnaldo Maria Giardina
Mario Grugni
Luca Francesco Raveglia
Original Assignee
Smithkline Beecham S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham S.P.A. filed Critical Smithkline Beecham S.P.A.
Publication of HUP9903584A2 publication Critical patent/HUP9903584A2/hu
Publication of HUP9903584A3 publication Critical patent/HUP9903584A3/hu

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány egy (I) általánős képletű vegyületnek -, amelynekképletében Ar adőtt esetben szűbsztitűált fenil-, naftil- vagy ciklőalkadienil-vagy heterőciklűsős csőpőrt; R alkil-, ciklőalkil-, ciklőalkil-alkil-, adőtt esetben szűbsztitűáltfenil-, fenil-alkil- vagy heterőarőmás csőpőrt, hidrőxi-alkil-, aminő-alkil-, alkil-aminő-alkil-, dialkil-aminő-alkil-, acil-aminő-alkil-,alkőxi-alkil-, alkil-karbőnil-, karbőxi-, alkőxi-karbőnil-, alkőxi-karbőnil-alkil-, karbamőil-, alkil-aminő-karbőnil-, dialkil-aminő-karbőnil-, halőgén-alkil-csőpőrt vagy az Ar csőpőrtra ciklizált -(CH2)p- csőpőrt, amelyben p értéke 2 vagy 3; R1 és R2 hidrőgénatőm, alkilcsőpőrt vagy együtt -(CH2)n-csőpőrt,amelyben n értéke 3, 4 vagy 5; vagy R1 és R együtt -(CH2)q-csőpőrt, amelyben q értéke 2, 3, 4 vagy 5; R3 és R4 hidrőgénatőm, alkil-, alkenil-, aril-, alkőxi-,hidrőxicsőpőrt, halőgénatőm, nitrő-, cianő-, karbőxi-, karbőxamidő-,szűlfőnamidő-, alkőxi-karbőnil-, triflűőr-metil-, acil-őxi-,ftálimidő-, aminő-, mőnő- vagy dialkil-aminő-, -O(CH2)r -NT2 csőpőrt,amelyben r értéke 2, 3 vagy 4, és T hidrőgénatőm, alkilcsőpőrt vagy a szőmszédős nitrőgénatőmal együttegy csőpőrtőt képez, amelyben V és V1 hidrőgénatőm vagy őxigénatőm, ésű értéke 0, 1 vagy 2; -O(CH2)s-OW2 csőpőrt, amelyben s értéke 2, 3vagy 4, és W hidrőgénatőm vagy alkilcsőpőrt; hidrőxi-alkil-, aminő-alkil-, mőnő- vagy dialkil-aminő-alkil-, acil-aminő-, alkil-szűlfőnil-aminő-, aminő-acil-aminő-csőpőrt, mőnő- vagy dialkil-aminő-acil-aminő-csőpőrt; és egyidejűleg legfeljebb négy R3 szűbsztitűens lehet akinőlinmagőn; vagy R4 az arőmás R5 csőpőrtra ciklizálva -(CH2)t- csőpőrt, amelyben tértéke 1, 2 vagy 3; R5 alkil-, ciklőalkil-, ciklőalkil-alkil-csőpőrt vagy adőtt esetbenszűbsztitűált heterőarilcőspőrt; X őxigén-, kénatőm vagy =N-C=N csőpőrt - egy sójára (a tővábbiakban(találmány szeirnti só) vagy egy ilyen sónak egy szőlvátjáravőnatkőzik, ahől a só egy aniőnős főrmában lévő (I) általánős képletűvegyületből és egy sóképző katiőnból áll. A találmány szerintivegyületek NK3 receptőr antagőnista hatással rendelkeznek, ígyfelhasználhatók - egyebek mellett - pűlmőnalis, közpőnti idegrendszeriés neűrődegeneratív rendellenességek kezelésére. A találmány kiterjeda vegyületek gyógyászati felhasználására, előállítási eljárásaikra,valamint a vegyületeket hatóanyagként tartalmazógyógyszerkészítményekre és ezek előállítási eljárásaira is. ŕ
HU9903584A 1995-11-24 1996-11-22 Salts of quinoline derivatives as nk3 antagonists HUP9903584A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9524137.8A GB9524137D0 (en) 1995-11-24 1995-11-24 Novel compounds
PCT/EP1996/005210 WO1997019928A1 (en) 1995-11-24 1996-11-22 Salts of quinoline derivatives as nk3 antagonists

Publications (2)

Publication Number Publication Date
HUP9903584A2 true HUP9903584A2 (hu) 2000-02-28
HUP9903584A3 HUP9903584A3 (en) 2001-10-29

Family

ID=10784449

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903584A HUP9903584A3 (en) 1995-11-24 1996-11-22 Salts of quinoline derivatives as nk3 antagonists

Country Status (23)

Country Link
US (3) US6355654B1 (hu)
EP (1) EP0876348B1 (hu)
JP (1) JP4377454B2 (hu)
KR (1) KR19990071599A (hu)
CN (1) CN1207728A (hu)
AR (1) AR004970A1 (hu)
AT (1) ATE233243T1 (hu)
AU (1) AU722451B2 (hu)
BR (1) BR9611729A (hu)
CA (1) CA2238312A1 (hu)
CZ (1) CZ158198A3 (hu)
DE (1) DE69626416T2 (hu)
ES (1) ES2192621T3 (hu)
GB (1) GB9524137D0 (hu)
HU (1) HUP9903584A3 (hu)
IL (1) IL124352A0 (hu)
MX (1) MX9804106A (hu)
NO (1) NO310866B1 (hu)
NZ (1) NZ323389A (hu)
PL (1) PL326927A1 (hu)
TR (1) TR199800925T2 (hu)
WO (1) WO1997019928A1 (hu)
ZA (1) ZA969812B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
JP2002540203A (ja) 1999-03-29 2002-11-26 ニューロゲン コーポレイション Nk−3および/またはgaba(a)受容体リガンドとしての4−置換キノリン誘導体
WO2000064877A1 (en) 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
US20080200500A1 (en) * 2005-06-03 2008-08-21 Astrazeneca Ab Quinoline Derivatives as Nk3 Antagonists
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
US20080194623A1 (en) * 2005-08-02 2008-08-14 Labaw Clifford S Method for the Synthesis of Quinoline Derivatives
EP1915363A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Oxopyridyl quinoline amides as nk3 receptor modulators
AR057130A1 (es) * 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
CN101268052A (zh) * 2005-09-21 2008-09-17 阿斯利康(瑞典)有限公司 作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
WO2007086799A1 (en) * 2006-01-27 2007-08-02 Astrazeneca Ab Amide substituted quinolines
FR2979173B1 (fr) * 2011-08-19 2013-08-16 St Microelectronics Grenoble 2 Commutateur analogique basse tension
CN104010504B (zh) 2011-11-03 2016-04-06 默沙东公司 作为mGluR2负变构调节剂的喹啉甲酰胺和喹啉甲腈的衍生物、组合物、及其用途
CA2909752A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2227769T3 (es) * 1994-05-27 2005-04-01 Glaxosmithkline S.P.A. Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina.
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
CN1207728A (zh) 1999-02-10
AU722451B2 (en) 2000-08-03
AU1031997A (en) 1997-06-19
AR004970A1 (es) 1999-04-07
US6432977B1 (en) 2002-08-13
DE69626416T2 (de) 2003-12-24
CZ158198A3 (cs) 1998-10-14
US20020156097A1 (en) 2002-10-24
WO1997019928A1 (en) 1997-06-05
US6355654B1 (en) 2002-03-12
ZA969812B (en) 1998-05-22
EP0876348B1 (en) 2003-02-26
US20020077335A1 (en) 2002-06-20
EP0876348A1 (en) 1998-11-11
ES2192621T3 (es) 2003-10-16
PL326927A1 (en) 1998-11-09
NO982332D0 (no) 1998-05-22
JP4377454B2 (ja) 2009-12-02
CA2238312A1 (en) 1997-06-05
KR19990071599A (ko) 1999-09-27
BR9611729A (pt) 1999-04-06
NO982332L (no) 1998-05-22
JP2000500770A (ja) 2000-01-25
GB9524137D0 (en) 1996-01-24
MX9804106A (es) 1998-09-30
NZ323389A (en) 2000-02-28
DE69626416D1 (de) 2003-04-03
TR199800925T2 (xx) 2001-05-21
HUP9903584A3 (en) 2001-10-29
ATE233243T1 (de) 2003-03-15
IL124352A0 (en) 1998-12-06
NO310866B1 (no) 2001-09-10

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