ATE232394T1 - Verwendung von modifiziertem c-reaktiven protein zur herstellung eines medikaments zur behandlung von krebs - Google Patents
Verwendung von modifiziertem c-reaktiven protein zur herstellung eines medikaments zur behandlung von krebsInfo
- Publication number
- ATE232394T1 ATE232394T1 AT93910710T AT93910710T ATE232394T1 AT E232394 T1 ATE232394 T1 AT E232394T1 AT 93910710 T AT93910710 T AT 93910710T AT 93910710 T AT93910710 T AT 93910710T AT E232394 T1 ATE232394 T1 AT E232394T1
- Authority
- AT
- Austria
- Prior art keywords
- mammal
- mcrp
- modified
- cancer
- reactive protein
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 108010074051 C-Reactive Protein Proteins 0.000 title abstract 2
- 102100032752 C-reactive protein Human genes 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 230000001571 immunoadjuvant effect Effects 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/874,263 US5283238A (en) | 1992-04-24 | 1992-04-24 | Methods of treating cancer using modified C-reactive protein |
| PCT/US1993/003769 WO1993021944A1 (en) | 1992-04-24 | 1993-04-22 | Methods of treating cancer using modified c-reactive protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE232394T1 true ATE232394T1 (de) | 2003-02-15 |
Family
ID=25363358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93910710T ATE232394T1 (de) | 1992-04-24 | 1993-04-22 | Verwendung von modifiziertem c-reaktiven protein zur herstellung eines medikaments zur behandlung von krebs |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5283238A (de) |
| EP (1) | EP0637246B1 (de) |
| JP (2) | JPH07505905A (de) |
| AT (1) | ATE232394T1 (de) |
| AU (1) | AU668168B2 (de) |
| CA (1) | CA2132001C (de) |
| DE (1) | DE69332688T2 (de) |
| WO (1) | WO1993021944A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593897A (en) * | 1988-04-04 | 1997-01-14 | Northwestern University | Binding of immune complexes by modified forms of C-reactive protein |
| US5405832A (en) * | 1991-11-27 | 1995-04-11 | Immtech International Inc. | Method of treating non-streptococcal bacterial infections |
| DE69230643T2 (de) * | 1991-11-27 | 2000-06-21 | Immtech International Inc., Evanston | Methode zur behandlung von viralen infektionen |
| US5874238A (en) * | 1993-02-26 | 1999-02-23 | Immtech International Inc. | Mutant protein and methods and materials for making and using it |
| US6703219B1 (en) | 1993-02-26 | 2004-03-09 | Immtech International Inc. | Mutant protein and methods and materials for making and using it |
| US5547931A (en) * | 1994-02-23 | 1996-08-20 | Immtech International Inc. | Methods of stimulatory thrombocytopoiesis using modified C-reactive protein |
| CA2341309A1 (en) * | 1998-08-19 | 2000-03-02 | Edward E. Diehl | Use of mcrp for delivery of materials into cells |
| US6331403B1 (en) | 1998-08-19 | 2001-12-18 | Lawrence A. Potempa | Use of mCRP to slow cell growth and to promote maturation of cells |
| US6190670B1 (en) | 1999-04-12 | 2001-02-20 | Immtech International Inc. | Use of mCRP to enhance immune responses |
| US7115665B1 (en) | 2000-11-16 | 2006-10-03 | Onocozyme Pharma, Inc. | Inhibitors of endo-exonuclease activity for treating cancer |
| DE60042245D1 (de) * | 1999-11-16 | 2009-07-02 | Oncozyme Pharma Inc | Pentamidine zur behandlung von krebs |
| US20030232394A1 (en) * | 2002-06-12 | 2003-12-18 | Aventis Pharma Deutschland Gmbh | High throughput screening method and assay system for determining the interaction between C-reactive protein and components binding to it |
| DE10226011A1 (de) * | 2002-06-12 | 2004-01-08 | Aventis Pharma Deutschland Gmbh | HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen c-reaktivem Protein und an C-reaktives Protein bindenden Komponenten |
| ITMI20022307A1 (it) * | 2002-10-30 | 2004-04-30 | Zetesis Spa | Associazioni anti-tumorali comprendenti proteine e chemioterapici. |
| JP5959440B2 (ja) | 2010-01-19 | 2016-08-02 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 病原体の検出および治療のための改変オプソニン |
| AU2012284097B2 (en) | 2011-07-18 | 2017-08-03 | President And Fellows Of Harvard College | Engineered microbe-targeting molecules and uses thereof |
| JP5713306B2 (ja) * | 2013-01-30 | 2015-05-07 | 国立大学法人秋田大学 | ガンのリンパ節転移抑制剤 |
| WO2014144325A1 (en) | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Methods and compositions for improving detection and/or capture of a target entity |
| WO2014190040A1 (en) | 2013-05-21 | 2014-11-27 | President And Fellows Of Harvard College | Engineered heme-binding compositions and uses thereof |
| EP3083658B1 (de) | 2013-12-18 | 2019-05-08 | President and Fellows of Harvard College | Detektion gram-positiver bakterien mit crp |
| EP3020726A1 (de) * | 2014-11-12 | 2016-05-18 | Pentracor GmbH | Verwendung einer Citrat-Lösung zur affinitätschromatographischen Aufreinigung von CRP mittels Phosphocholin und dessen Derivaten |
| EP3763378A1 (de) | 2015-08-06 | 2021-01-13 | President and Fellows of Harvard College | Verbesserte mikrobenbindende moleküle und verwendungen davon |
| TWI892737B (zh) | 2020-03-17 | 2025-08-01 | 日商紀和化學工業股份有限公司 | 染料組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444744A (en) * | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| US4816402A (en) * | 1986-01-07 | 1989-03-28 | Northwestern University | Murine hybridoma and diagnostic antibody produced thereby |
| US4857314A (en) * | 1986-07-18 | 1989-08-15 | Health Research , Inc. | C-reactive proteins in treatment of animal and human cancers |
| AU633488B2 (en) * | 1988-04-04 | 1993-02-04 | Northwestern University | Binding of immune complexes by modified forms of c-reactive protein |
-
1992
- 1992-04-24 US US07/874,263 patent/US5283238A/en not_active Expired - Fee Related
-
1993
- 1993-04-22 DE DE69332688T patent/DE69332688T2/de not_active Expired - Fee Related
- 1993-04-22 AT AT93910710T patent/ATE232394T1/de not_active IP Right Cessation
- 1993-04-22 CA CA002132001A patent/CA2132001C/en not_active Expired - Fee Related
- 1993-04-22 WO PCT/US1993/003769 patent/WO1993021944A1/en not_active Ceased
- 1993-04-22 AU AU41109/93A patent/AU668168B2/en not_active Ceased
- 1993-04-22 EP EP93910710A patent/EP0637246B1/de not_active Expired - Lifetime
- 1993-04-22 JP JP5519361A patent/JPH07505905A/ja active Pending
- 1993-11-09 US US08/149,663 patent/US5474904A/en not_active Expired - Fee Related
-
2003
- 2003-01-06 JP JP2003000624A patent/JP3810741B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0637246A4 (de) | 1996-03-27 |
| JP3810741B2 (ja) | 2006-08-16 |
| US5283238A (en) | 1994-02-01 |
| DE69332688T2 (de) | 2003-10-16 |
| AU668168B2 (en) | 1996-04-26 |
| EP0637246B1 (de) | 2003-02-12 |
| WO1993021944A1 (en) | 1993-11-11 |
| JPH07505905A (ja) | 1995-06-29 |
| CA2132001A1 (en) | 1993-11-11 |
| JP2003267894A (ja) | 2003-09-25 |
| DE69332688D1 (de) | 2003-03-20 |
| CA2132001C (en) | 2000-02-15 |
| EP0637246A1 (de) | 1995-02-08 |
| AU4110993A (en) | 1993-11-29 |
| US5474904A (en) | 1995-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee | ||
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |