KR930700163A - 연조직 종양의 치료 및/또는 진단 방법 - Google Patents
연조직 종양의 치료 및/또는 진단 방법Info
- Publication number
- KR930700163A KR930700163A KR1019920702364A KR920702364A KR930700163A KR 930700163 A KR930700163 A KR 930700163A KR 1019920702364 A KR1019920702364 A KR 1019920702364A KR 920702364 A KR920702364 A KR 920702364A KR 930700163 A KR930700163 A KR 930700163A
- Authority
- KR
- South Korea
- Prior art keywords
- metal
- ligand
- molar ratio
- formulation
- soft tissue
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (22)
- (1) 리간드 및 금속 이온을 포함하는 착화합물(여기서, 리간드는 하이드록시에틸에틸렌디아민트리아세트산 또는 그의 약학적으로 허용되는 염이고, 금속 이온은153Sm,166Ho,90Y,165Dy,159Gd,177Lu,111In,115mIn,175Yb,47Sc,52Fe,72Ga.67Ga,68Ga, Gd 또는 Fe이며, 리간드 대 금속의 몰비는 적어도 50 : 1 이다), 및 (2) 생리학적으로 허용되는 액체 담체를 포함하는 효과량의 조성물을 연조직 종양을 가진 포유동물에 투여함을 포함하는, 연조직 종양을 가진 포유동물의 치료학적 및/또는 진단학적 치료방법.
- 제1항에 있어서, 치료학적 치료를 위한 방법.
- 제2항에 있어서, 상기 금속 이온이166Ho,90Y,175Yb,165Dy,115mIn,52Fe 또는72Ga인 방법.
- 제1항에 있어서, 진단학적 치료를 위한 방법.
- 제4항에 있어서, 상기 금속이111In,67Ga,68Ga, Gd 또는 Fe인 방법.
- 제1항에 있어서, 치료학적 치료 및 진단학적 치료 모두를 위한 방법.
- 제6항에 있어서, 상기 금속이153Sm,177Lu,175Yb,159Gd 또는47Sc인 방법.
- 제7항에 있어서, 상기 금속이153Sm인 방법.
- 제1항 내지 제8항 중 어느 한 항에 있어서, 상기 리간드 대 금속의 몰비가 50 : 1 내지 600 : 1인 방법.
- 제9항에 있어서, 상기 리간드 대 금속의 몰비가 100 : 1 내지 500 : 1인 방법.
- 제10항에 있어서, 상기 리간드 대 금속의 몰비가 250 : 1 내지 300 : 1인 방법.
- 제1항 내지 제8항 중 어느 한 항에 있어서, 사용된 금속이 담체가 전혀 첨가되지 않은 형태인 방법.
- 제12항에 있어서, 상기 리간드 대 금속의 몰비가 약 5×107: 1인 방법.
- 제1항 내지 제8항 중 어느 한 항에 있어서, 상기 생리학적으로 허용되는 액체 담체가 물이고, 생성된 용액이 약 7 내지 약 8의 pH를 갖도록 조절된 방법.
- 제1항에 있어서, 상기 리간드가 나트륨염의 형태인 방법.
- 제1항에 있어서, 포유동물에게 투여된 조성물이 2가지 이상의 상이한 방사성 동위원소를 함유할 수 있는 방법.
- (1) 리간드 및 금속 이온을 포함하는 착화합물(여기서, 리간드는 하이드록시에틸에틸렌디아민트리아세트산 또는 그의 약학적으로 허용되는 염이고, 금속 이온은153Sm,166Ho,90Y,165Dy,159Gd,177Lu, In111,115mIn,175Yb,47Sc,52Fe,72Ga,67Ga,68Ga, Gd 또는 Fe이며, 리간드 대 금속의 몰비는 적어도 50 : 1 이다), 및 (2) 생리학적으로 허용되는 액체 담체를 포함하는 효과량의 조성물을 포함하는, 연조직 종양을 가진 포유동물의 치료학적 및/또는 진단학적 치료용 약학 제제.
- 제17항에 있어서, 상기 리간드 대 금속의 몰비가 50 : 1 내지 600 : 1인 제제.
- 제18항에 있어서, 상기 리간드 대 금속의 몰비가 1O0 : 1 내지 500 : 1인 제제.
- 제19항에 있어서, 상기 리간드 대 금속의 몰비가 250 : 1 내지 300 : 1인 제제.
- 제17항에 있어서, 상기 금속이153Sm,177Lu,175Yb,159Gd 또는47Sc인 제제.
- 제21항에 있어서, 상기 금속이153Sm인 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/648,663 US5308606A (en) | 1991-01-30 | 1991-01-30 | Method of treating and/or diagnosing soft tissue tumors |
US648,663 | 1991-01-30 | ||
PCT/US1992/000683 WO1992013571A1 (en) | 1991-01-30 | 1992-01-30 | Method of treating and/or diagnosing soft tissue tumors |
Publications (2)
Publication Number | Publication Date |
---|---|
KR930700163A true KR930700163A (ko) | 1993-03-13 |
KR100219965B1 KR100219965B1 (ko) | 1999-09-01 |
Family
ID=24601702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920702364A KR100219965B1 (ko) | 1991-01-30 | 1992-09-29 | 연조직종양의 치료 및/또는 진단방법 |
Country Status (17)
Country | Link |
---|---|
US (1) | US5308606A (ko) |
EP (1) | EP0499098B1 (ko) |
JP (1) | JPH05505629A (ko) |
KR (1) | KR100219965B1 (ko) |
AT (1) | ATE216266T1 (ko) |
AU (1) | AU650944B2 (ko) |
CA (1) | CA2060332A1 (ko) |
DE (1) | DE69232554T2 (ko) |
FI (1) | FI924363A (ko) |
IE (1) | IE920311A1 (ko) |
IL (1) | IL100800A (ko) |
MX (1) | MX9200413A (ko) |
NZ (1) | NZ241463A (ko) |
SG (1) | SG45366A1 (ko) |
TW (1) | TW205509B (ko) |
WO (1) | WO1992013571A1 (ko) |
ZA (1) | ZA92663B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5739313A (en) * | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
MXPA02003772A (es) | 1999-10-15 | 2005-04-28 | Mayo Foundation | Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes terapeuticos. |
US7591995B2 (en) * | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
AU4243400A (en) * | 1999-10-15 | 2001-04-30 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging agents and as antitumor agents |
EP1334114A2 (en) * | 2000-10-25 | 2003-08-13 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
WO2003000010A2 (en) * | 2001-06-20 | 2003-01-03 | Mayo Foundation For Medical Education And Research | Adenosyl-cobalamin fortified compositions |
US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
CA2461705A1 (en) * | 2001-09-28 | 2003-04-03 | Mayo Foundation For Medical Education And Research | Coadministration of transport protein with conjugated cobalamin to deliver agents |
KR100440725B1 (ko) * | 2002-06-20 | 2004-07-15 | 주식회사 그린진 바이오텍 | 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법 |
WO2007008232A2 (en) * | 2004-09-03 | 2007-01-18 | Board Of Regents, The University Of Texas System | Locoregional internal radionuclide ablation of abnormal tissues. |
US7419654B2 (en) * | 2004-10-08 | 2008-09-02 | Mrinal K. Dewanjee | Charge neutral complexes of paramagnetic metals as intracellular magnetic resonance imaging contrast agents |
WO2006124870A1 (en) * | 2005-05-17 | 2006-11-23 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US421452A (en) * | 1890-02-18 | Island | ||
US4898724A (en) * | 1984-06-04 | 1990-02-06 | The Dow Chemical Company | Organis amine phosphonic acid complexes for the treatment of calcific tumors |
DE3577550D1 (de) * | 1984-09-21 | 1990-06-13 | Dow Chemical Co | Aminocarbonsaeurekomplexe zur behandlung von knochentumoren. |
US4897254A (en) * | 1984-09-21 | 1990-01-30 | The Dow Chemical Company | Radioactive compositions for the treatment of calcific tumors |
NZ222304A (en) * | 1987-05-18 | 1990-10-26 | Dow Chemical Co | Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes |
-
1991
- 1991-01-30 US US07/648,663 patent/US5308606A/en not_active Expired - Lifetime
-
1992
- 1992-01-29 IL IL10080092A patent/IL100800A/en not_active IP Right Cessation
- 1992-01-29 AU AU10543/92A patent/AU650944B2/en not_active Ceased
- 1992-01-30 TW TW081100713A patent/TW205509B/zh active
- 1992-01-30 WO PCT/US1992/000683 patent/WO1992013571A1/en active Application Filing
- 1992-01-30 ZA ZA92663A patent/ZA92663B/xx unknown
- 1992-01-30 JP JP92506262A patent/JPH05505629A/ja not_active Ceased
- 1992-01-30 DE DE69232554T patent/DE69232554T2/de not_active Expired - Fee Related
- 1992-01-30 MX MX9200413A patent/MX9200413A/es not_active IP Right Cessation
- 1992-01-30 SG SG1996004830A patent/SG45366A1/en unknown
- 1992-01-30 NZ NZ241463A patent/NZ241463A/xx unknown
- 1992-01-30 CA CA002060332A patent/CA2060332A1/en not_active Abandoned
- 1992-01-30 IE IE031192A patent/IE920311A1/en unknown
- 1992-01-30 AT AT92101569T patent/ATE216266T1/de not_active IP Right Cessation
- 1992-01-30 EP EP92101569A patent/EP0499098B1/en not_active Expired - Lifetime
- 1992-09-29 FI FI924363A patent/FI924363A/fi unknown
- 1992-09-29 KR KR1019920702364A patent/KR100219965B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU1054392A (en) | 1992-08-06 |
IE920311A1 (en) | 1992-07-29 |
KR100219965B1 (ko) | 1999-09-01 |
SG45366A1 (en) | 1998-01-16 |
NZ241463A (en) | 2000-01-28 |
ZA92663B (en) | 1993-07-30 |
JPH05505629A (ja) | 1993-08-19 |
ATE216266T1 (de) | 2002-05-15 |
IL100800A0 (en) | 1992-09-06 |
WO1992013571A1 (en) | 1992-08-20 |
EP0499098B1 (en) | 2002-04-17 |
TW205509B (ko) | 1993-05-11 |
FI924363A0 (fi) | 1992-09-29 |
CA2060332A1 (en) | 1992-07-31 |
US5308606A (en) | 1994-05-03 |
FI924363A (fi) | 1992-09-29 |
DE69232554T2 (de) | 2002-08-08 |
EP0499098A2 (en) | 1992-08-19 |
AU650944B2 (en) | 1994-07-07 |
DE69232554D1 (de) | 2002-05-23 |
EP0499098A3 (en) | 1992-08-26 |
MX9200413A (es) | 1992-08-01 |
IL100800A (en) | 1996-10-31 |
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