ATE227343T1 - Protease und verwandte dns-verbindungen - Google Patents
Protease und verwandte dns-verbindungenInfo
- Publication number
- ATE227343T1 ATE227343T1 AT93304103T AT93304103T ATE227343T1 AT E227343 T1 ATE227343 T1 AT E227343T1 AT 93304103 T AT93304103 T AT 93304103T AT 93304103 T AT93304103 T AT 93304103T AT E227343 T1 ATE227343 T1 AT E227343T1
- Authority
- AT
- Austria
- Prior art keywords
- protease
- related dna
- dna compounds
- compounds
- provides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Neurology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89154292A | 1992-05-28 | 1992-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE227343T1 true ATE227343T1 (de) | 2002-11-15 |
Family
ID=25398377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93304103T ATE227343T1 (de) | 1992-05-28 | 1993-05-26 | Protease und verwandte dns-verbindungen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5733768A (de) |
| EP (1) | EP0576152B1 (de) |
| JP (1) | JP3568552B2 (de) |
| KR (1) | KR930023465A (de) |
| AT (1) | ATE227343T1 (de) |
| AU (1) | AU670080B2 (de) |
| BR (1) | BR9302075A (de) |
| CA (1) | CA2096911C (de) |
| CZ (1) | CZ98293A3 (de) |
| DE (1) | DE69332462T2 (de) |
| ES (1) | ES2185621T3 (de) |
| FI (1) | FI932425L (de) |
| HU (1) | HUT69612A (de) |
| IL (1) | IL105793A0 (de) |
| MX (1) | MX9303082A (de) |
| NO (1) | NO931889L (de) |
| PL (1) | PL299053A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531586B1 (en) | 1995-04-28 | 2003-03-11 | The Hospital For Sick Children | Genetic sequences related to Alzheimer's Disease |
| US6210919B1 (en) | 1995-04-28 | 2001-04-03 | Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease |
| US5986054A (en) * | 1995-04-28 | 1999-11-16 | The Hospital For Sick Children, Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease |
| JPH11507538A (ja) * | 1995-06-07 | 1999-07-06 | アテナ ニューロサイエンシズ インコーポレイティド | β−セクレターゼ、β−セクレターゼに対する抗体、及びβ−セクレターゼ阻害を検出するためのアッセイ |
| US5744346A (en) * | 1995-06-07 | 1998-04-28 | Athena Neurosciences, Inc. | β-secretase |
| US6329163B1 (en) | 1995-06-07 | 2001-12-11 | Elan Pharmaceuticals, Inc. | Assays for detecting β-secretase inhibition |
| JP2000506375A (ja) * | 1996-01-26 | 2000-05-30 | エイチエスシー リサーチ アンド デベロップメント リミテッド パートナーシップ | アルツハイマー病に関連する核酸およびタンパク質、ならびにその使用 |
| AU4480797A (en) * | 1996-09-13 | 1998-04-02 | Dana-Farber Cancer Institute | Protease m, a novel serine protease |
| CA2330242A1 (fr) * | 1998-06-05 | 1999-12-16 | Aventis Pharma S.A. | Polypeptides possedant une activite de type beta-secretase |
| FR2779444A1 (fr) * | 1998-06-05 | 1999-12-10 | Rhone Poulenc Rorer Sa | Polypeptides possedant une activite de type beta-secretase et capables de cliver le precurseur naturel du peptide beta-amyloide (app) |
| WO2000001807A1 (en) * | 1998-07-02 | 2000-01-13 | Fuso Pharmaceutical Industries, Ltd. | Serine protease-specific monoclonal antibody and utilization thereof |
| US20040234976A1 (en) * | 1998-09-24 | 2004-11-25 | Gurney Mark E. | Alzheimer's disease secretase, app substrates therefor, and uses therefor |
| US6699671B1 (en) | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
| NZ510708A (en) * | 1998-09-24 | 2003-12-19 | Upjohn Co | Alzheimer's disease and Asp1 and Asp2 cleaving APP site (beta secretase) |
| US6844148B1 (en) | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
| US6245884B1 (en) | 1998-10-16 | 2001-06-12 | Vivian Y. H. Hook | Secretases related to alzheimer's dementia |
| US6313268B1 (en) | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
| US7456007B1 (en) | 1998-12-31 | 2008-11-25 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| US7115410B1 (en) * | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| HK1044545A1 (zh) | 1999-02-10 | 2002-10-25 | Elan Pharmaceuticals, Inc. | 贝他分泌酶组合物及其方法 |
| US20020049303A1 (en) * | 1999-06-28 | 2002-04-25 | Tang Jordan J. N. | Catalytically active recombinant memapsin and methods of use thereof |
| EP1194449B1 (de) * | 1999-06-28 | 2010-09-22 | Oklahoma Medical Research Foundation | Inhibitoren des memapsin 2 und ihre verwendung |
| US20090162883A1 (en) * | 1999-09-23 | 2009-06-25 | Pharmacia & Upjohn Company | Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof |
| US7514408B1 (en) | 1999-12-02 | 2009-04-07 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| CA2360219A1 (en) | 2000-10-27 | 2002-04-27 | Mount Sinai Hospital | Method for detecting alzheimer's disease |
| EP1330652B1 (de) * | 2000-10-27 | 2007-06-27 | Mount Sinai Hospital | Verfahren zur erkennung von eierstockkrebs mittels menschlichem kallikrein (hk6) |
| US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
| AU2002359301B2 (en) * | 2001-10-23 | 2008-07-03 | Comentis, Inc. | Beta-secretase inhibitors and methods of use |
| US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
| US20050106586A1 (en) * | 2003-06-13 | 2005-05-19 | Mount Sinai Hospital | Detection of neurodegenerative diseases |
| AU2006279896A1 (en) * | 2005-08-10 | 2007-02-22 | Oklahoma Medical Research Foundation | Truncated memapsin 2 for use for treating Alzheimer's disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT62312A (en) * | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
| US5252463A (en) * | 1990-06-22 | 1993-10-12 | The Du Pont Merck Pharmaceutical Company | Clipsin, a chymotrypsin-like protease and method of using same |
| HUT69771A (en) * | 1990-08-17 | 1995-09-28 | Univ Boston | Proteases causing abnormal degradation of amyloid beta-proteine precursors |
| US5292652A (en) * | 1990-10-05 | 1994-03-08 | Athena Neurosciences, Inc. | Amyloidin protease and uses thereof |
-
1993
- 1993-05-24 IL IL105793A patent/IL105793A0/xx unknown
- 1993-05-25 CA CA002096911A patent/CA2096911C/en not_active Expired - Lifetime
- 1993-05-25 NO NO931889A patent/NO931889L/no unknown
- 1993-05-25 PL PL29905393A patent/PL299053A1/xx unknown
- 1993-05-26 ES ES93304103T patent/ES2185621T3/es not_active Expired - Lifetime
- 1993-05-26 DE DE69332462T patent/DE69332462T2/de not_active Expired - Lifetime
- 1993-05-26 MX MX9303082A patent/MX9303082A/es unknown
- 1993-05-26 AT AT93304103T patent/ATE227343T1/de not_active IP Right Cessation
- 1993-05-26 EP EP93304103A patent/EP0576152B1/de not_active Expired - Lifetime
- 1993-05-26 BR BR9302075A patent/BR9302075A/pt not_active Application Discontinuation
- 1993-05-27 KR KR1019930009456A patent/KR930023465A/ko not_active Withdrawn
- 1993-05-27 AU AU39864/93A patent/AU670080B2/en not_active Ceased
- 1993-05-27 JP JP12576093A patent/JP3568552B2/ja not_active Expired - Lifetime
- 1993-05-27 FI FI932425A patent/FI932425L/fi not_active Application Discontinuation
- 1993-05-27 HU HU9301557A patent/HUT69612A/hu unknown
- 1993-06-23 CZ CZ93982A patent/CZ98293A3/cs unknown
-
1994
- 1994-12-22 US US08/361,395 patent/US5733768A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MX9303082A (es) | 1994-06-30 |
| KR930023465A (ko) | 1993-12-18 |
| AU670080B2 (en) | 1996-07-04 |
| CZ98293A3 (en) | 1994-02-16 |
| DE69332462D1 (de) | 2002-12-12 |
| EP0576152A1 (de) | 1993-12-29 |
| ES2185621T3 (es) | 2003-05-01 |
| HU9301557D0 (en) | 1993-10-28 |
| NO931889D0 (no) | 1993-05-25 |
| NO931889L (no) | 1993-11-29 |
| BR9302075A (pt) | 1993-11-30 |
| FI932425A7 (fi) | 1993-11-29 |
| DE69332462T2 (de) | 2003-07-10 |
| US5733768A (en) | 1998-03-31 |
| HUT69612A (en) | 1995-09-28 |
| PL299053A1 (en) | 1994-02-21 |
| IL105793A0 (en) | 1993-09-22 |
| FI932425L (fi) | 1993-11-29 |
| EP0576152B1 (de) | 2002-11-06 |
| CA2096911C (en) | 2004-11-02 |
| CA2096911A1 (en) | 1993-11-29 |
| FI932425A0 (fi) | 1993-05-27 |
| JPH0662855A (ja) | 1994-03-08 |
| AU3986493A (en) | 1993-12-02 |
| JP3568552B2 (ja) | 2004-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |