ATE227341T1 - Trimerisierende polypeptide, deren herstellung und verwendung - Google Patents

Trimerisierende polypeptide, deren herstellung und verwendung

Info

Publication number
ATE227341T1
ATE227341T1 AT95918689T AT95918689T ATE227341T1 AT E227341 T1 ATE227341 T1 AT E227341T1 AT 95918689 T AT95918689 T AT 95918689T AT 95918689 T AT95918689 T AT 95918689T AT E227341 T1 ATE227341 T1 AT E227341T1
Authority
AT
Austria
Prior art keywords
polypeptides
amino acid
amino acids
preparation
heterotrimerization
Prior art date
Application number
AT95918689T
Other languages
English (en)
Inventor
Hans-Juergen Hoppe
Kenneth Bannerman Reid
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE227341T1 publication Critical patent/ATE227341T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
AT95918689T 1994-05-16 1995-05-16 Trimerisierende polypeptide, deren herstellung und verwendung ATE227341T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409768A GB9409768D0 (en) 1994-05-16 1994-05-16 Trimerising polypeptides
PCT/GB1995/001104 WO1995031540A1 (en) 1994-05-16 1995-05-16 Trimerising polypeptides, their manufacture and use

Publications (1)

Publication Number Publication Date
ATE227341T1 true ATE227341T1 (de) 2002-11-15

Family

ID=10755201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918689T ATE227341T1 (de) 1994-05-16 1995-05-16 Trimerisierende polypeptide, deren herstellung und verwendung

Country Status (12)

Country Link
US (1) US6190886B1 (de)
EP (1) EP0757720B1 (de)
JP (2) JPH10500298A (de)
AT (1) ATE227341T1 (de)
AU (1) AU2451995A (de)
CA (1) CA2190264A1 (de)
DE (1) DE69528761T2 (de)
DK (1) DK0757720T3 (de)
ES (1) ES2186718T3 (de)
GB (1) GB9409768D0 (de)
PT (1) PT757720E (de)
WO (1) WO1995031540A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
DE69738670D1 (de) * 1996-10-28 2008-06-19 Inst Suisse De Rech S Experime Verfahren zur oligomerisation von peptiden
WO1998018918A1 (en) * 1996-10-29 1998-05-07 Commonwealth Scientific And Industrial Research Organisation Stable expression of triple helical proteins
ATE282092T1 (de) 1997-06-11 2004-11-15 Borean Pharma As Trimerisierendes modul
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
WO1999027964A1 (en) * 1997-12-01 1999-06-10 Cfy Biomedicals, Inc. Multivalent recombinant antibodies for treating hrv infections
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
US7300774B1 (en) * 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
JP2003502024A (ja) * 1999-05-14 2003-01-21 メディカル リサーチ カウンシル タンパク質骨格および単量体ポリペプチドを多量体化するためのその使用
AU2002213843B2 (en) 2000-11-10 2008-02-07 F. Hoffmann-La Roche Ltd. Apolipoprotein analogues
CA2440235A1 (en) * 2001-03-06 2002-09-12 Mustapha Abdelouahed Carrier chimeric proteins, targeted carrier chimeric proteins and preparation thereof
CA2454358A1 (en) 2001-07-19 2003-07-31 Perlan Therapeutics, Inc. Multimeric proteins and methods of making and using same
DK1440083T3 (da) 2001-10-25 2013-03-25 Medical Res Council Molekyler
AU2002359780B2 (en) * 2001-12-21 2009-08-13 Immunex Corporation Recombinant polypeptides
US20070010658A1 (en) 2002-10-29 2007-01-11 Holtet Thor L Trimeric binding proteins for trimeric cytokines
US20080166798A1 (en) * 2003-08-22 2008-07-10 Barnes-Jewish Hospital Trimerizing Polypeptides and Their Uses
US7268116B2 (en) * 2003-10-02 2007-09-11 Genhunter Corp. Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
US8030448B2 (en) 2004-02-16 2011-10-04 Techno Network Shikoku Co., Ltd. Polypeptide having collagen-like structure
NZ555353A (en) 2004-11-22 2009-12-24 Anaphore Inc TNF antagonists
EP1960525B1 (de) * 2005-09-09 2013-04-24 Zymogenetics, Inc. Verfahren zur herstellung trimerer proteine
US10183986B2 (en) 2005-12-15 2019-01-22 Industrial Technology Research Institute Trimeric collagen scaffold antibodies
US20070264687A1 (en) * 2005-12-15 2007-11-15 Min-Yuan Chou Recombinant triplex scaffold-based polypeptides
EP2674440B1 (de) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Polyvalente bioaktive anordnungen auf immunglobulinbasis
CN103159857B (zh) * 2007-05-21 2014-11-05 财团法人工业技术研究院 以重组的三股螺旋支架为基础的复合物
CA2692802C (en) * 2007-07-10 2017-05-30 Oliver Hill Tnf superfamily collectin fusion proteins
CA2704207A1 (en) 2007-10-29 2009-05-07 Virginia Tech Intellectual Properties, Inc. Porcine dc-sign, icam-3 and lsectin and uses thereof
EP2294202B1 (de) 2008-07-08 2015-05-20 Medicago Inc. Lösliche rekombinante influenza-antigene
EP2379585A2 (de) 2008-10-10 2011-10-26 Anaphore, Inc. Trail-r1 und trail-r2 bindende polypeptide
DK2380979T3 (da) * 2008-12-22 2015-06-22 Univ Hokkaido Nat Univ Corp Proteinstof med trippelhelixstruktur samt fremgangsmåde til dets fremstilling
JP5844158B2 (ja) * 2009-01-09 2016-01-13 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツングＡｐｏｇｅｎｉｘ ＧｍｂＨ 三量体形成融合タンパク質
WO2010122181A1 (es) * 2009-04-20 2010-10-28 Universidad Autónoma de Madrid Proteínas oligoméricas y sus aplicaciones
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
US20110086770A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Combinatorial Libraries Based on C-type Lectin-like Domain
DK2970427T3 (da) 2013-03-15 2020-03-09 Geoffrey W Stone Sammensætning bestående af antigen bundet til en tnf-superfamilieligand
JP2014218510A (ja) * 2014-08-11 2014-11-20 アポゲニクスゲゼルシャフト ミット ベシュレンクテルハフツングＡｐｏｇｅｎｉｘ ＧｍｂＨ 三量体形成融合タンパク質
EP3374378B1 (de) 2015-11-13 2021-02-17 Spiber Technologies AB Ladungsumgekehrte n-terminale spinnenseidenproteindomäne und verwendungen davon
GB201522610D0 (en) * 2015-12-22 2016-02-03 Univ Southampton Protein
JP2016210791A (ja) * 2016-08-03 2016-12-15 アポゲニクス アーゲー 三量体形成融合タンパク質
US11377490B2 (en) 2017-05-31 2022-07-05 Sichuan Clover Biopharmaceuticals, Inc Method for treating cancer using disulfide-linked trimeric 4-1BBL
WO2021249011A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Hiv vaccine compositions, methods, and uses thereof
WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins

Also Published As

Publication number Publication date
WO1995031540A1 (en) 1995-11-23
DK0757720T3 (da) 2003-03-17
DE69528761D1 (de) 2002-12-12
JPH10500298A (ja) 1998-01-13
PT757720E (pt) 2003-03-31
ES2186718T3 (es) 2003-05-16
EP0757720A1 (de) 1997-02-12
CA2190264A1 (en) 1995-11-23
AU2451995A (en) 1995-12-05
GB9409768D0 (en) 1994-07-06
EP0757720B1 (de) 2002-11-06
JP2005328851A (ja) 2005-12-02
DE69528761T2 (de) 2003-07-17
JP3836865B2 (ja) 2006-10-25
US6190886B1 (en) 2001-02-20

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