ATE226451T1 - Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger - Google Patents

Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger

Info

Publication number
ATE226451T1
ATE226451T1 AT98937757T AT98937757T ATE226451T1 AT E226451 T1 ATE226451 T1 AT E226451T1 AT 98937757 T AT98937757 T AT 98937757T AT 98937757 T AT98937757 T AT 98937757T AT E226451 T1 ATE226451 T1 AT E226451T1
Authority
AT
Austria
Prior art keywords
water
complex
pharmaceutically active
active ingredients
pharmaceutical active
Prior art date
Application number
AT98937757T
Other languages
English (en)
Inventor
Marco Fabrizio Saettone
Boris Giannaccini
Enrico Boldrini
Pietro Bianchini
Original Assignee
Farmigea Spa
Marco Fabrizio Saettone
Boris Giannaccini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmigea Spa, Marco Fabrizio Saettone, Boris Giannaccini filed Critical Farmigea Spa
Application granted granted Critical
Publication of ATE226451T1 publication Critical patent/ATE226451T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
AT98937757T 1997-07-23 1998-07-22 Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger ATE226451T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000456A IT1294205B1 (it) 1997-07-23 1997-07-23 Procedimento per la solubilizzazione in acqua e in veicoli acquosi di sostanze farmacologicamente attive
PCT/IT1998/000206 WO1999004823A1 (en) 1997-07-23 1998-07-22 Process for solubilizing pharmaceutically active ingredients in water and in aqueous vehicles

Publications (1)

Publication Number Publication Date
ATE226451T1 true ATE226451T1 (de) 2002-11-15

Family

ID=11405192

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98937757T ATE226451T1 (de) 1997-07-23 1998-07-22 Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger

Country Status (11)

Country Link
US (1) US6346273B1 (de)
EP (1) EP0994727B1 (de)
JP (1) JP2001510810A (de)
AT (1) ATE226451T1 (de)
AU (1) AU8645098A (de)
DE (1) DE69808911T2 (de)
EA (1) EA002326B1 (de)
ES (1) ES2186197T3 (de)
IT (1) IT1294205B1 (de)
PT (1) PT994727E (de)
WO (1) WO1999004823A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845305A1 (de) * 1998-10-01 2000-04-06 Beiersdorf Ag Verwendung von oberflächenaktiven Citronensäureestern zur Stabilisierung von Flavonen, Flavanonen bzw. Flavonoiden, synergistische Gemische aus Flavonen, Flavanonen bzw. Flavonoiden und oberflächenaktiven Substanzen sowie kosmetische und dermatologische Zubereitungen mit einem Gehalt an solchen Gemischen
WO2002028363A1 (en) * 2000-10-05 2002-04-11 Unimed Pharma Spol S.R.O. Eye instillation with decongestant effect
US6866396B2 (en) * 2002-10-09 2005-03-15 Jji Lighting Group, Inc. Illuminating device with rotatably adjustable support
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
JP2007510621A (ja) * 2003-07-29 2007-04-26 シグニチャー アールアンドディー ホールディングス，エルエルシー． アミノ酸プロドラッグ
US6960300B2 (en) * 2003-09-08 2005-11-01 Sami Labs Limited Process for preparing water soluble diterpenes and their applications
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
CA2571554A1 (en) * 2004-06-28 2006-01-19 Alza Corporation A drug/polymer complex, preferably ciprofloxacin/hpmc, its method of manufacturing using lyophilization and its use in an osmotic device
US20100260691A1 (en) * 2006-07-31 2010-10-14 Narayanan Kolazi S Aqueous compositions containing a hydrophobic material
US20100239629A1 (en) * 2006-07-31 2010-09-23 Isp Investments Inc. Delivery system for delivering bioactive materials
WO2008035109A1 (en) 2006-09-22 2008-03-27 Cipla Limited Rifaximin
US8747871B2 (en) * 2006-09-28 2014-06-10 Isp Investments Inc. Synergistic matrix composite for making stable microemulsions of active ingredients
US9717584B2 (en) * 2007-04-13 2017-08-01 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
KR20110107806A (ko) * 2008-12-10 2011-10-04 시플라 리미티드 리팍시민 복합체
RU2523562C1 (ru) * 2013-05-23 2014-07-20 Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России) Способ получения таблеток рутина
US9814560B2 (en) 2013-12-05 2017-11-14 W. L. Gore & Associates, Inc. Tapered implantable device and methods for making such devices
CN110946684B (zh) 2015-06-05 2022-06-03 W.L.戈尔及同仁股份有限公司 带有渐缩部的低渗血量可植入假体
WO2017103840A1 (en) * 2015-12-16 2017-06-22 MOHAMED ABDULLA ANZAR, Cheppattu A water soluble 10% w/w forskolin composition and a method of synthesizing the same
PL3565602T3 (pl) * 2017-01-09 2021-09-13 SciPharm S.à r.l. Nowy sposób wytwarzania rozpuszczalnej w wodzie forskoliny
JP6506787B2 (ja) 2017-03-06 2019-04-24 ストローブ株式会社 成膜方法
AU2021211146A1 (en) 2020-01-23 2022-09-01 SciPharm S.à r.l. Complex of 7-deacetyforskoline and PVP
KR20220149987A (ko) * 2021-05-03 2022-11-10 연세대학교 산학협력단 안구건조증 또는 안구건조증 연관 안과 질환의 예방, 개선 또는 치료용 조성물
WO2023027670A2 (en) * 2021-08-23 2023-03-02 Tum Ekip Ilac Anonim Sirketi Lyophilized levosimendan compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883785A (en) * 1984-07-27 1989-11-28 Chow Wing Sun Complex of anti-fungal agent and cyclodextrin and method
US4900775A (en) 1988-02-29 1990-02-13 Gaf Chemicals Corporation Solubilization of complexes of water-insoluble organic compounds by aqueous solutions of polyvinylpyrrolidone
AU5036590A (en) 1989-02-24 1990-09-26 Gaf Chemicals Corporation Solubilization of indomethacin and piroxicam by a quaternized polymer
IL89530A0 (en) 1989-03-08 1989-09-10 Jeffrey J Feigenbaum Compositions containing forskolin
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
AU2531295A (en) * 1994-05-27 1995-12-21 Farmarc Nederland Bv Pharmaceutical composition
CZ301382B6 (cs) * 1997-03-12 2010-02-10 Abbott Laboratories Chad377/Ap6D-2 Hydrofilní binární systémy pro podávání cyklosporinu

Also Published As

Publication number Publication date
ITRM970456A0 (de) 1997-07-23
EP0994727A1 (de) 2000-04-26
PT994727E (pt) 2003-03-31
WO1999004823A1 (en) 1999-02-04
DE69808911D1 (de) 2002-11-28
AU8645098A (en) 1999-02-16
EA002326B1 (ru) 2002-04-25
US6346273B1 (en) 2002-02-12
ES2186197T3 (es) 2003-05-01
DE69808911T2 (de) 2003-06-12
EA200000154A1 (ru) 2000-10-30
JP2001510810A (ja) 2001-08-07
IT1294205B1 (it) 1999-03-24
ITRM970456A1 (it) 1999-01-23
EP0994727B1 (de) 2002-10-23

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