DE69808911T2 - Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger - Google Patents

Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger

Info

Publication number
DE69808911T2
DE69808911T2 DE69808911T DE69808911T DE69808911T2 DE 69808911 T2 DE69808911 T2 DE 69808911T2 DE 69808911 T DE69808911 T DE 69808911T DE 69808911 T DE69808911 T DE 69808911T DE 69808911 T2 DE69808911 T2 DE 69808911T2
Authority
DE
Germany
Prior art keywords
water
complex
active substances
pharmaceutically active
solving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69808911T
Other languages
English (en)
Other versions
DE69808911D1 (de
Inventor
Fabrizio Saettone
Boris Giannaccini
Enrico Boldrini
Pietro Bianchini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmigea SpA
Original Assignee
Farmigea SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmigea SpA filed Critical Farmigea SpA
Publication of DE69808911D1 publication Critical patent/DE69808911D1/de
Application granted granted Critical
Publication of DE69808911T2 publication Critical patent/DE69808911T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69808911T 1997-07-23 1998-07-22 Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger Expired - Fee Related DE69808911T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000456A IT1294205B1 (it) 1997-07-23 1997-07-23 Procedimento per la solubilizzazione in acqua e in veicoli acquosi di sostanze farmacologicamente attive
PCT/IT1998/000206 WO1999004823A1 (en) 1997-07-23 1998-07-22 Process for solubilizing pharmaceutically active ingredients in water and in aqueous vehicles

Publications (2)

Publication Number Publication Date
DE69808911D1 DE69808911D1 (de) 2002-11-28
DE69808911T2 true DE69808911T2 (de) 2003-06-12

Family

ID=11405192

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69808911T Expired - Fee Related DE69808911T2 (de) 1997-07-23 1998-07-22 Verfahren zum lösen von pharmazeutischen wirkstoffen in wasser und in wässrige träger

Country Status (11)

Country Link
US (1) US6346273B1 (de)
EP (1) EP0994727B1 (de)
JP (1) JP2001510810A (de)
AT (1) ATE226451T1 (de)
AU (1) AU8645098A (de)
DE (1) DE69808911T2 (de)
EA (1) EA002326B1 (de)
ES (1) ES2186197T3 (de)
IT (1) IT1294205B1 (de)
PT (1) PT994727E (de)
WO (1) WO1999004823A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845305A1 (de) * 1998-10-01 2000-04-06 Beiersdorf Ag Verwendung von oberflächenaktiven Citronensäureestern zur Stabilisierung von Flavonen, Flavanonen bzw. Flavonoiden, synergistische Gemische aus Flavonen, Flavanonen bzw. Flavonoiden und oberflächenaktiven Substanzen sowie kosmetische und dermatologische Zubereitungen mit einem Gehalt an solchen Gemischen
WO2002028363A1 (en) * 2000-10-05 2002-04-11 Unimed Pharma Spol S.R.O. Eye instillation with decongestant effect
US6866396B2 (en) * 2002-10-09 2005-03-15 Jji Lighting Group, Inc. Illuminating device with rotatably adjustable support
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
KR20120116991A (ko) * 2003-07-29 2012-10-23 시그너쳐 알 앤드 디 홀딩스, 엘엘씨 아미노산 프로드럭
US6960300B2 (en) * 2003-09-08 2005-11-01 Sami Labs Limited Process for preparing water soluble diterpenes and their applications
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
EP1761265A2 (de) * 2004-06-28 2007-03-14 ALZA Corporation Arzneimittel/polymer-komplex, vorzugsweise ciprofloxacin/hpmc, sein herstellungsverfahren mit lyophilisation und seine verwendung in einer osmotischen vorrichtung
US20100239629A1 (en) * 2006-07-31 2010-09-23 Isp Investments Inc. Delivery system for delivering bioactive materials
US20100260691A1 (en) * 2006-07-31 2010-10-14 Narayanan Kolazi S Aqueous compositions containing a hydrophobic material
AU2007298733B2 (en) 2006-09-22 2012-11-08 Cipla Limited Rifaximin
US8747871B2 (en) * 2006-09-28 2014-06-10 Isp Investments Inc. Synergistic matrix composite for making stable microemulsions of active ingredients
US9717584B2 (en) * 2007-04-13 2017-08-01 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
CA2745980C (en) * 2008-12-10 2017-10-31 Cipla Limited Rifaximin complexes
RU2523562C1 (ru) * 2013-05-23 2014-07-20 Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России) Способ получения таблеток рутина
US9814560B2 (en) 2013-12-05 2017-11-14 W. L. Gore & Associates, Inc. Tapered implantable device and methods for making such devices
CN107666882B (zh) 2015-06-05 2020-01-10 W.L.戈尔及同仁股份有限公司 带有渐缩部的低渗血量可植入假体
WO2017103840A1 (en) * 2015-12-16 2017-06-22 MOHAMED ABDULLA ANZAR, Cheppattu A water soluble 10% w/w forskolin composition and a method of synthesizing the same
SI3565602T1 (sl) 2017-01-09 2021-07-30 Scipharm S.A R.L. Nov postopek za pripravo vodotopnega forskolina
JP6506787B2 (ja) 2017-03-06 2019-04-24 ストローブ株式会社 成膜方法
PT4093374T (pt) 2020-01-23 2024-01-23 Scipharm S A R L Complexo de 7- deacetil forscolina e pvp
KR20220149987A (ko) * 2021-05-03 2022-11-10 연세대학교 산학협력단 안구건조증 또는 안구건조증 연관 안과 질환의 예방, 개선 또는 치료용 조성물
WO2023027670A2 (en) * 2021-08-23 2023-03-02 Tum Ekip Ilac Anonim Sirketi Lyophilized levosimendan compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883785A (en) 1984-07-27 1989-11-28 Chow Wing Sun Complex of anti-fungal agent and cyclodextrin and method
US4900775A (en) * 1988-02-29 1990-02-13 Gaf Chemicals Corporation Solubilization of complexes of water-insoluble organic compounds by aqueous solutions of polyvinylpyrrolidone
WO1990010021A1 (en) * 1989-02-24 1990-09-07 Gaf Chemicals Corporation Solubilization of indomethacin and piroxicam by a quaternized polymer
IL89530A0 (en) * 1989-03-08 1989-09-10 Jeffrey J Feigenbaum Compositions containing forskolin
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
AU2531295A (en) * 1994-05-27 1995-12-21 Farmarc Nederland Bv Pharmaceutical composition
IL131609A0 (en) * 1997-03-12 2001-01-28 Abbott Lab Hydrophilic binary systems for the administration of cyclosporine

Also Published As

Publication number Publication date
EA200000154A1 (ru) 2000-10-30
IT1294205B1 (it) 1999-03-24
ITRM970456A1 (it) 1999-01-23
ATE226451T1 (de) 2002-11-15
EA002326B1 (ru) 2002-04-25
ITRM970456A0 (de) 1997-07-23
WO1999004823A1 (en) 1999-02-04
EP0994727B1 (de) 2002-10-23
PT994727E (pt) 2003-03-31
EP0994727A1 (de) 2000-04-26
US6346273B1 (en) 2002-02-12
DE69808911D1 (de) 2002-11-28
ES2186197T3 (es) 2003-05-01
JP2001510810A (ja) 2001-08-07
AU8645098A (en) 1999-02-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee