ATE224367T1 - Verfahren zur herstellung von indolderivaten - Google Patents
Verfahren zur herstellung von indolderivatenInfo
- Publication number
- ATE224367T1 ATE224367T1 AT98933651T AT98933651T ATE224367T1 AT E224367 T1 ATE224367 T1 AT E224367T1 AT 98933651 T AT98933651 T AT 98933651T AT 98933651 T AT98933651 T AT 98933651T AT E224367 T1 ATE224367 T1 AT E224367T1
- Authority
- AT
- Austria
- Prior art keywords
- indole derivatives
- producing indole
- producing
- derivatives
- indole
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9714383.8A GB9714383D0 (en) | 1997-07-08 | 1997-07-08 | Improved process |
| PCT/EP1998/003996 WO1999002493A1 (en) | 1997-07-08 | 1998-06-16 | Process for the production of indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224367T1 true ATE224367T1 (de) | 2002-10-15 |
Family
ID=10815557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98933651T ATE224367T1 (de) | 1997-07-08 | 1998-06-16 | Verfahren zur herstellung von indolderivaten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6281357B1 (de) |
| EP (1) | EP0975594B1 (de) |
| AR (1) | AR013183A1 (de) |
| AT (1) | ATE224367T1 (de) |
| AU (1) | AU8339798A (de) |
| CA (1) | CA2286720A1 (de) |
| DE (1) | DE69808068T2 (de) |
| DK (1) | DK0975594T3 (de) |
| ES (1) | ES2182342T3 (de) |
| GB (1) | GB9714383D0 (de) |
| IL (1) | IL132442A0 (de) |
| PL (1) | PL337000A1 (de) |
| PT (1) | PT975594E (de) |
| WO (1) | WO1999002493A1 (de) |
| ZA (1) | ZA985918B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9801690D0 (en) * | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
| US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| CN1729174B (zh) | 2002-12-20 | 2015-10-21 | 西巴特殊化学品控股有限公司 | 胺的合成以及用于合成胺的中间体 |
| US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
| CN102775342A (zh) * | 2011-05-12 | 2012-11-14 | 上海医药工业研究院 | 一种抗偏头痛药物阿莫曲坦的制备方法 |
| EP3680241A1 (de) | 2017-03-20 | 2020-07-15 | Forma Therapeutics, Inc. | Pyrrolopyrrolzusammensetzungen als pyruvatkinase(pkr)-aktivatoren |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US10675274B2 (en) | 2018-09-19 | 2020-06-09 | Forma Therapeutics, Inc. | Activating pyruvate kinase R |
| CN110483341A (zh) * | 2019-07-23 | 2019-11-22 | 上海药明康德新药开发有限公司 | 一种1-氰基-n-甲基甲磺酰胺的合成方法 |
| HUE072832T2 (hu) | 2019-09-19 | 2025-12-28 | Novo Nordisk Healthcare Ag | Piruvát kináz R-t (PKR) aktiváló készítmények |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
| CA2091562C (en) * | 1990-10-15 | 2001-03-27 | John Eugene Macor | Indole derivatives useful in psychotherapeutics |
| GB9103770D0 (en) * | 1991-02-22 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
-
1997
- 1997-07-08 GB GBGB9714383.8A patent/GB9714383D0/en active Pending
-
1998
- 1998-06-16 IL IL13244298A patent/IL132442A0/xx unknown
- 1998-06-16 CA CA002286720A patent/CA2286720A1/en not_active Abandoned
- 1998-06-16 AT AT98933651T patent/ATE224367T1/de not_active IP Right Cessation
- 1998-06-16 DK DK98933651T patent/DK0975594T3/da active
- 1998-06-16 PL PL98337000A patent/PL337000A1/xx unknown
- 1998-06-16 DE DE69808068T patent/DE69808068T2/de not_active Expired - Fee Related
- 1998-06-16 PT PT98933651T patent/PT975594E/pt unknown
- 1998-06-16 ES ES98933651T patent/ES2182342T3/es not_active Expired - Lifetime
- 1998-06-16 US US09/381,072 patent/US6281357B1/en not_active Expired - Fee Related
- 1998-06-16 EP EP98933651A patent/EP0975594B1/de not_active Expired - Lifetime
- 1998-06-16 WO PCT/EP1998/003996 patent/WO1999002493A1/en not_active Ceased
- 1998-06-16 AU AU83397/98A patent/AU8339798A/en not_active Abandoned
- 1998-07-06 ZA ZA9805918A patent/ZA985918B/xx unknown
- 1998-07-06 AR ARP980103279A patent/AR013183A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU8339798A (en) | 1999-02-08 |
| DK0975594T3 (da) | 2002-10-14 |
| DE69808068D1 (de) | 2002-10-24 |
| ES2182342T3 (es) | 2003-03-01 |
| GB9714383D0 (en) | 1997-09-10 |
| AR013183A1 (es) | 2000-12-13 |
| PL337000A1 (en) | 2000-07-31 |
| IL132442A0 (en) | 2001-03-19 |
| US6281357B1 (en) | 2001-08-28 |
| CA2286720A1 (en) | 1999-01-21 |
| ZA985918B (en) | 2000-01-10 |
| DE69808068T2 (de) | 2003-02-06 |
| EP0975594B1 (de) | 2002-09-18 |
| EP0975594A1 (de) | 2000-02-02 |
| PT975594E (pt) | 2002-12-31 |
| WO1999002493A1 (en) | 1999-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |