ATE222259T1 - Prodrugs von paclitaxel-derivaten - Google Patents

Prodrugs von paclitaxel-derivaten

Info

Publication number
ATE222259T1
ATE222259T1 AT96109044T AT96109044T ATE222259T1 AT E222259 T1 ATE222259 T1 AT E222259T1 AT 96109044 T AT96109044 T AT 96109044T AT 96109044 T AT96109044 T AT 96109044T AT E222259 T1 ATE222259 T1 AT E222259T1
Authority
AT
Austria
Prior art keywords
prodrugs
paclitaxel derivatives
paclitaxel
derivatives
Prior art date
Application number
AT96109044T
Other languages
English (en)
Inventor
Paul M Scola
John F Kadow
Dolatrai M Vyas
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE222259T1 publication Critical patent/ATE222259T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
AT96109044T 1995-06-06 1996-06-05 Prodrugs von paclitaxel-derivaten ATE222259T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46924795A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
ATE222259T1 true ATE222259T1 (de) 2002-08-15

Family

ID=23863053

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96109044T ATE222259T1 (de) 1995-06-06 1996-06-05 Prodrugs von paclitaxel-derivaten

Country Status (23)

Country Link
EP (1) EP0747385B1 (de)
JP (1) JPH08337589A (de)
KR (1) KR100375956B1 (de)
CN (1) CN1066151C (de)
AR (1) AR002756A1 (de)
AT (1) ATE222259T1 (de)
AU (1) AU695959B2 (de)
CA (1) CA2176191A1 (de)
CZ (1) CZ291516B6 (de)
DE (1) DE69622933T2 (de)
DK (1) DK0747385T3 (de)
ES (1) ES2181824T3 (de)
HU (1) HUP9601524A3 (de)
IL (1) IL118526A (de)
MX (1) MX9601994A (de)
NO (1) NO315233B1 (de)
NZ (1) NZ286723A (de)
PL (1) PL187883B1 (de)
PT (1) PT747385E (de)
RU (1) RU2162082C2 (de)
SG (1) SG72692A1 (de)
TW (1) TW354293B (de)
ZA (1) ZA964261B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395770B1 (en) * 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
IL132992A0 (en) * 1997-05-27 2001-03-19 Baker Norton Pharma Method and compositions for administering taxanes orally to human patients
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2000048606A1 (en) * 1999-02-18 2000-08-24 Oxigene, Inc. Compositions and methods for use in targeting vascular destruction
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
SK13702001A3 (sk) 2000-02-02 2002-06-04 Florida State University Research Foundation, Inc. Taxány substituované v polohe C7 karbonátom ako protinádorové činidlo
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
KR20030049023A (ko) * 2001-12-13 2003-06-25 주식회사 코오롱 방사선 감작제용 파클리탁셀 유도체
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
EA201892726A1 (ru) 2013-03-15 2019-04-30 Консерт Фармасьютикалс, Инк. Дейтерированный палбоциклиб
WO2015009889A1 (en) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Deuterated intedanib derivatives and their use for the treatment of proliferative disorders
SG11201803645PA (en) * 2015-11-19 2018-06-28 Biohaven Pharm Holding Co Ltd Amine prodrugs of pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9308012A (es) * 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives

Also Published As

Publication number Publication date
CN1066151C (zh) 2001-05-23
EP0747385B1 (de) 2002-08-14
CA2176191A1 (en) 1996-12-07
RU2162082C2 (ru) 2001-01-20
NO962231L (no) 1996-12-09
PL314637A1 (en) 1996-12-09
HU9601524D0 (en) 1996-07-29
NO315233B1 (no) 2003-08-04
AU5471896A (en) 1996-12-19
TW354293B (en) 1999-03-11
AU695959B2 (en) 1998-08-27
KR970000222A (ko) 1997-01-21
PT747385E (pt) 2002-11-29
KR100375956B1 (ko) 2003-04-21
CN1144805A (zh) 1997-03-12
EP0747385A1 (de) 1996-12-11
NZ286723A (en) 1998-03-25
HUP9601524A2 (en) 1997-05-28
NO962231D0 (no) 1996-05-31
HUP9601524A3 (en) 2000-03-28
PL187883B1 (pl) 2004-10-29
DK0747385T3 (da) 2002-12-16
SG72692A1 (en) 2000-05-23
IL118526A0 (en) 1996-10-16
JPH08337589A (ja) 1996-12-24
ES2181824T3 (es) 2003-03-01
MX9601994A (es) 1997-08-30
DE69622933T2 (de) 2003-04-24
DE69622933D1 (de) 2002-09-19
ZA964261B (en) 1997-11-27
AR002756A1 (es) 1998-04-29
CZ156396A3 (en) 1996-12-11
IL118526A (en) 2001-05-20
CZ291516B6 (cs) 2003-03-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee