DE69622933T2 - Prodrugs von Paclitaxel-Derivaten - Google Patents

Prodrugs von Paclitaxel-Derivaten

Info

Publication number
DE69622933T2
DE69622933T2 DE69622933T DE69622933T DE69622933T2 DE 69622933 T2 DE69622933 T2 DE 69622933T2 DE 69622933 T DE69622933 T DE 69622933T DE 69622933 T DE69622933 T DE 69622933T DE 69622933 T2 DE69622933 T2 DE 69622933T2
Authority
DE
Germany
Prior art keywords
prodrugs
paclitaxel derivatives
paclitaxel
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69622933T
Other languages
English (en)
Other versions
DE69622933D1 (de
Inventor
Paul M Scola
John F Kadow
Dolatrai M Vyas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69622933D1 publication Critical patent/DE69622933D1/de
Publication of DE69622933T2 publication Critical patent/DE69622933T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69622933T 1995-06-06 1996-06-05 Prodrugs von Paclitaxel-Derivaten Expired - Fee Related DE69622933T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46924795A 1995-06-06 1995-06-06

Publications (2)

Publication Number Publication Date
DE69622933D1 DE69622933D1 (de) 2002-09-19
DE69622933T2 true DE69622933T2 (de) 2003-04-24

Family

ID=23863053

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69622933T Expired - Fee Related DE69622933T2 (de) 1995-06-06 1996-06-05 Prodrugs von Paclitaxel-Derivaten

Country Status (23)

Country Link
EP (1) EP0747385B1 (de)
JP (1) JPH08337589A (de)
KR (1) KR100375956B1 (de)
CN (1) CN1066151C (de)
AR (1) AR002756A1 (de)
AT (1) ATE222259T1 (de)
AU (1) AU695959B2 (de)
CA (1) CA2176191A1 (de)
CZ (1) CZ291516B6 (de)
DE (1) DE69622933T2 (de)
DK (1) DK0747385T3 (de)
ES (1) ES2181824T3 (de)
HU (1) HUP9601524A3 (de)
IL (1) IL118526A (de)
MX (1) MX9601994A (de)
NO (1) NO315233B1 (de)
NZ (1) NZ286723A (de)
PL (1) PL187883B1 (de)
PT (1) PT747385E (de)
RU (1) RU2162082C2 (de)
SG (1) SG72692A1 (de)
TW (1) TW354293B (de)
ZA (1) ZA964261B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395770B1 (en) * 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
BR9809694A (pt) * 1997-05-27 2000-10-03 Baker Norton Pharma Processo e composição para administração de taxanos oralmente a pacientes humanos
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2000048606A1 (en) * 1999-02-18 2000-08-24 Oxigene, Inc. Compositions and methods for use in targeting vascular destruction
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
IL145637A0 (en) 2000-02-02 2002-06-30 Univ Florida State Res Found C7 carbonate substituted taxanes as antitumor agents
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
KR20030049023A (ko) * 2001-12-13 2003-06-25 주식회사 코오롱 방사선 감작제용 파클리탁셀 유도체
EP1737444A4 (de) 2004-03-05 2008-05-21 Univ Florida State Res Found C7-lactyloxa-substituierte taxane
CN103143069B (zh) * 2005-02-18 2016-05-04 阿布拉西斯生物科学公司 用于整合入医疗装置的疏水性改善的药物
EA032094B1 (ru) 2013-03-15 2019-04-30 Консерт Фармасьютикалс, Инк. Дейтерированный палбоциклиб
WO2015009889A1 (en) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Deuterated intedanib derivatives and their use for the treatment of proliferative disorders
US20180318268A1 (en) * 2015-11-19 2018-11-08 Biohaven Pharmaceutical Holding Company Ltd. Amine prodrugs of pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives

Also Published As

Publication number Publication date
MX9601994A (es) 1997-08-30
ES2181824T3 (es) 2003-03-01
AU5471896A (en) 1996-12-19
NO315233B1 (no) 2003-08-04
CN1066151C (zh) 2001-05-23
NZ286723A (en) 1998-03-25
HUP9601524A3 (en) 2000-03-28
DK0747385T3 (da) 2002-12-16
PT747385E (pt) 2002-11-29
KR100375956B1 (ko) 2003-04-21
NO962231L (no) 1996-12-09
AU695959B2 (en) 1998-08-27
KR970000222A (ko) 1997-01-21
EP0747385A1 (de) 1996-12-11
SG72692A1 (en) 2000-05-23
CZ156396A3 (en) 1996-12-11
HU9601524D0 (en) 1996-07-29
CZ291516B6 (cs) 2003-03-12
PL187883B1 (pl) 2004-10-29
CN1144805A (zh) 1997-03-12
IL118526A0 (en) 1996-10-16
RU2162082C2 (ru) 2001-01-20
PL314637A1 (en) 1996-12-09
ZA964261B (en) 1997-11-27
HUP9601524A2 (en) 1997-05-28
TW354293B (en) 1999-03-11
AR002756A1 (es) 1998-04-29
DE69622933D1 (de) 2002-09-19
IL118526A (en) 2001-05-20
ATE222259T1 (de) 2002-08-15
EP0747385B1 (de) 2002-08-14
NO962231D0 (no) 1996-05-31
CA2176191A1 (en) 1996-12-07
JPH08337589A (ja) 1996-12-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee