ATE219044T1 - Fluorosubstituierte adamantan-derivate - Google Patents
Fluorosubstituierte adamantan-derivateInfo
- Publication number
- ATE219044T1 ATE219044T1 AT98302196T AT98302196T ATE219044T1 AT E219044 T1 ATE219044 T1 AT E219044T1 AT 98302196 T AT98302196 T AT 98302196T AT 98302196 T AT98302196 T AT 98302196T AT E219044 T1 ATE219044 T1 AT E219044T1
- Authority
- AT
- Austria
- Prior art keywords
- relates
- adamantane
- formula
- fluorosubstituted
- containing pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/15—Saturated compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4465897P | 1997-04-10 | 1997-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE219044T1 true ATE219044T1 (de) | 2002-06-15 |
Family
ID=21933590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98302196T ATE219044T1 (de) | 1997-04-10 | 1998-03-24 | Fluorosubstituierte adamantan-derivate |
Country Status (10)
Country | Link |
---|---|
US (1) | US6057364A (de) |
EP (1) | EP0870757B1 (de) |
JP (2) | JP2951313B2 (de) |
AT (1) | ATE219044T1 (de) |
BR (1) | BR9801157A (de) |
CA (1) | CA2234319C (de) |
DE (1) | DE69805909T2 (de) |
DK (1) | DK0870757T3 (de) |
ES (1) | ES2175614T3 (de) |
PT (1) | PT870757E (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6444702B1 (en) * | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
JP2002040648A (ja) * | 2000-07-28 | 2002-02-06 | Sony Corp | 露光方法 |
US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
US7795468B2 (en) * | 2001-01-19 | 2010-09-14 | Chevron U.S.A. Inc. | Functionalized higher diamondoids |
EP1757575A4 (de) * | 2004-06-16 | 2008-05-07 | Asahi Glass Co Ltd | Fluoradamantanderivat |
WO2005123650A1 (ja) * | 2004-06-16 | 2005-12-29 | Asahi Glass Company, Limited | 新規なフッ素化されたアダマンタン誘導体 |
US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
PL1874282T3 (pl) | 2005-04-06 | 2011-04-29 | Adamas Pharmaceuticals Inc | Sposoby i kompozycje do leczenia zaburzeń OUN |
EP1924562A2 (de) * | 2005-08-31 | 2008-05-28 | F.Hoffmann-La Roche Ag | Pyrazolonderivate |
JP5132238B2 (ja) * | 2007-10-05 | 2013-01-30 | 国立大学法人北海道大学 | フッ素化アダマンタン化合物の製造方法 |
US8399519B2 (en) | 2008-12-19 | 2013-03-19 | Merz Pharma Gmbh & Co. Kgaa | 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases |
TWI432188B (zh) * | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類 |
CN102883601A (zh) | 2009-12-02 | 2013-01-16 | 阿达玛斯医药公司 | 金刚烷胺组合物及其使用方法 |
EP2744771B1 (de) * | 2011-08-19 | 2020-10-21 | The Trustees of Princeton University | Herstellung einer c-halogen-bindung |
GB201206984D0 (en) * | 2012-04-20 | 2012-06-06 | Univ Manchester | New therapeutic use |
WO2014204933A1 (en) | 2013-06-17 | 2014-12-24 | Adamas Pharmaceuticals, Inc. | Amantadine compositions and methods of use |
RU2616255C1 (ru) * | 2016-05-16 | 2017-04-13 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | ПРИМЕНЕНИЕ (1S,3aR,4R,7aS)-N-(2,2,4,7a-ТЕТРАМЕТИЛОКТАГИДРО-1,4-ЭТАНОИНДЕН-3а-ИЛ)-АЦЕТАМИДА В КАЧЕСТВЕ ИНГИБИТОРА РЕПРОДУКЦИИ ВИРУСА ГРИППА |
US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2937211A (en) * | 1958-10-17 | 1960-05-17 | Du Pont | Chemical process |
US3352912A (en) * | 1963-07-24 | 1967-11-14 | Du Pont | Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes |
US3391142A (en) * | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
US4030994A (en) * | 1971-06-18 | 1977-06-21 | Merck & Co., Inc. | Substitutive fluorination of organic compounds |
GB1513135A (en) * | 1974-06-04 | 1978-06-07 | Res Inst For Med & Chem Inc | Fluorination process and fluoro steroids |
FR2514006A1 (fr) * | 1981-10-05 | 1983-04-08 | Nativelle Sa Ets | Acylamino-4 aza-1 adamantanes, procede pour leur preparation, et application en therapeutique |
ES8206435A1 (es) * | 1981-10-29 | 1982-08-16 | Especialidades Farmaco Terape | Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico |
US4829086A (en) * | 1984-03-14 | 1989-05-09 | Bodor Nicholas S | Soft β-adrenergic blocking agents |
FR2572399B1 (fr) * | 1984-10-31 | 1987-01-16 | Panmedica Sa | Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant |
LU85849A1 (fr) * | 1985-04-11 | 1986-11-05 | Cird | Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques |
US5482940A (en) * | 1988-05-24 | 1996-01-09 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
JP3136206B2 (ja) * | 1991-10-22 | 2001-02-19 | 中外製薬株式会社 | ベンゾジオキサン誘導体 |
PT757685E (pt) * | 1994-04-29 | 2004-10-29 | Pfizer | Novas amidas ciclicas como incrementadores de libertacao de neurotransmissores |
US5599998A (en) * | 1994-10-24 | 1997-02-04 | Iowa State University Research Foundation, Inc. | Method for the synthesis of adamantane amines |
-
1998
- 1998-03-24 DE DE69805909T patent/DE69805909T2/de not_active Expired - Fee Related
- 1998-03-24 DK DK98302196T patent/DK0870757T3/da active
- 1998-03-24 AT AT98302196T patent/ATE219044T1/de not_active IP Right Cessation
- 1998-03-24 PT PT98302196T patent/PT870757E/pt unknown
- 1998-03-24 EP EP98302196A patent/EP0870757B1/de not_active Expired - Lifetime
- 1998-03-24 ES ES98302196T patent/ES2175614T3/es not_active Expired - Lifetime
- 1998-04-08 CA CA002234319A patent/CA2234319C/en not_active Expired - Fee Related
- 1998-04-08 BR BR9801157A patent/BR9801157A/pt not_active Application Discontinuation
- 1998-04-09 US US09/057,694 patent/US6057364A/en not_active Expired - Fee Related
- 1998-04-09 JP JP10097707A patent/JP2951313B2/ja not_active Expired - Fee Related
-
1999
- 1999-04-27 JP JP11990499A patent/JP3338400B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6057364A (en) | 2000-05-02 |
DE69805909D1 (de) | 2002-07-18 |
JP2951313B2 (ja) | 1999-09-20 |
EP0870757A2 (de) | 1998-10-14 |
JP2000026367A (ja) | 2000-01-25 |
CA2234319A1 (en) | 1998-10-10 |
EP0870757A3 (de) | 2000-06-07 |
BR9801157A (pt) | 2000-03-21 |
JPH10298135A (ja) | 1998-11-10 |
EP0870757B1 (de) | 2002-06-12 |
DE69805909T2 (de) | 2002-09-26 |
ES2175614T3 (es) | 2002-11-16 |
CA2234319C (en) | 2003-03-25 |
DK0870757T3 (da) | 2002-07-15 |
JP3338400B2 (ja) | 2002-10-28 |
PT870757E (pt) | 2002-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |