ATE218553T1 - 1,4-disubstituierte cyclohexan-derivate als liganden der 5ht1a rezeptoren - Google Patents
1,4-disubstituierte cyclohexan-derivate als liganden der 5ht1a rezeptorenInfo
- Publication number
- ATE218553T1 ATE218553T1 AT98949063T AT98949063T ATE218553T1 AT E218553 T1 ATE218553 T1 AT E218553T1 AT 98949063 T AT98949063 T AT 98949063T AT 98949063 T AT98949063 T AT 98949063T AT E218553 T1 ATE218553 T1 AT E218553T1
- Authority
- AT
- Austria
- Prior art keywords
- triazine
- cyclohexane derivatives
- concerns
- ligands
- dioxo
- Prior art date
Links
- -1 1,4-DISUBSTITUTED CYCLOHEXANE Chemical class 0.000 title 1
- 102000017911 HTR1A Human genes 0.000 title 1
- 101150015707 HTR1A gene Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- HFBHPHBIBAUDNE-UHFFFAOYSA-N 2h-1,2,4-triazin-3-one Chemical group O=C1N=CC=NN1 HFBHPHBIBAUDNE-UHFFFAOYSA-N 0.000 abstract 1
- GFJDLRANNRSMCK-UHFFFAOYSA-N 6-amino-2h-1,2,4-triazine-3,5-dione Chemical compound NC1=NNC(=O)NC1=O GFJDLRANNRSMCK-UHFFFAOYSA-N 0.000 abstract 1
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical group O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9712954A FR2769913B1 (fr) | 1997-10-16 | 1997-10-16 | Nouveaux derives cyclohexaniques difonctionnalises en 1, 4, leur preparation et leur application therapeutique humaine |
| PCT/FR1998/002207 WO1999020613A1 (fr) | 1997-10-16 | 1998-10-14 | Derives cyclohexaniques difonctionnalises en 1,4, en tant que ligands des recepteurs 5ht1a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218553T1 true ATE218553T1 (de) | 2002-06-15 |
Family
ID=9512297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98949063T ATE218553T1 (de) | 1997-10-16 | 1998-10-14 | 1,4-disubstituierte cyclohexan-derivate als liganden der 5ht1a rezeptoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6191130B1 (de) |
| EP (1) | EP1023273B1 (de) |
| JP (1) | JP4454848B2 (de) |
| CN (1) | CN1127490C (de) |
| AT (1) | ATE218553T1 (de) |
| AU (1) | AU737178B2 (de) |
| BR (1) | BR9812939B1 (de) |
| CA (1) | CA2306429C (de) |
| DE (1) | DE69805831T2 (de) |
| DK (1) | DK1023273T3 (de) |
| ES (1) | ES2177064T3 (de) |
| FR (1) | FR2769913B1 (de) |
| PT (1) | PT1023273E (de) |
| WO (1) | WO1999020613A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11307553A (ja) * | 1998-04-21 | 1999-11-05 | Shinkawa Ltd | 半導体ペレットの位置決め方法及びその装置 |
| PA8802101A1 (es) * | 2007-11-02 | 2009-08-26 | Abbott Gmbh & Co Kg | Compuestos de 1,2,4-3,5-diona adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina d3 |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| US9505753B2 (en) | 2012-08-08 | 2016-11-29 | The Johns Hopkins University | Inhibitors of D-amino acid oxidase |
| US11311552B2 (en) | 2015-04-02 | 2022-04-26 | Proximagen, Llc | Therapies for cancer |
| CN111454250B (zh) * | 2019-01-21 | 2021-05-07 | 华东理工大学 | 多靶点活性化合物及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
| FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
-
1997
- 1997-10-16 FR FR9712954A patent/FR2769913B1/fr not_active Expired - Fee Related
-
1998
- 1998-10-14 DE DE69805831T patent/DE69805831T2/de not_active Expired - Lifetime
- 1998-10-14 PT PT98949063T patent/PT1023273E/pt unknown
- 1998-10-14 US US09/529,783 patent/US6191130B1/en not_active Expired - Lifetime
- 1998-10-14 CA CA2306429A patent/CA2306429C/fr not_active Expired - Fee Related
- 1998-10-14 AT AT98949063T patent/ATE218553T1/de active
- 1998-10-14 BR BRPI9812939-2A patent/BR9812939B1/pt not_active IP Right Cessation
- 1998-10-14 EP EP98949063A patent/EP1023273B1/de not_active Expired - Lifetime
- 1998-10-14 DK DK98949063T patent/DK1023273T3/da active
- 1998-10-14 WO PCT/FR1998/002207 patent/WO1999020613A1/fr not_active Ceased
- 1998-10-14 JP JP2000516955A patent/JP4454848B2/ja not_active Expired - Fee Related
- 1998-10-14 ES ES98949063T patent/ES2177064T3/es not_active Expired - Lifetime
- 1998-10-14 CN CN98811038A patent/CN1127490C/zh not_active Expired - Fee Related
- 1998-10-14 AU AU95458/98A patent/AU737178B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001520223A (ja) | 2001-10-30 |
| CA2306429A1 (fr) | 1999-04-29 |
| FR2769913A1 (fr) | 1999-04-23 |
| BR9812939B1 (pt) | 2009-12-01 |
| US6191130B1 (en) | 2001-02-20 |
| AU9545898A (en) | 1999-05-10 |
| DE69805831T2 (de) | 2003-01-23 |
| CN1278800A (zh) | 2001-01-03 |
| EP1023273A1 (de) | 2000-08-02 |
| FR2769913B1 (fr) | 2000-03-10 |
| ES2177064T3 (es) | 2002-12-01 |
| EP1023273B1 (de) | 2002-06-05 |
| DK1023273T3 (da) | 2002-09-30 |
| BR9812939A (pt) | 2000-08-08 |
| PT1023273E (pt) | 2002-10-31 |
| CN1127490C (zh) | 2003-11-12 |
| CA2306429C (fr) | 2010-03-30 |
| JP4454848B2 (ja) | 2010-04-21 |
| DE69805831D1 (de) | 2002-07-11 |
| WO1999020613A1 (fr) | 1999-04-29 |
| AU737178B2 (en) | 2001-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |