ATE211733T1 - Dihydropyridine als npy-antagonisten: piperidinderivate - Google Patents
Dihydropyridine als npy-antagonisten: piperidinderivateInfo
- Publication number
- ATE211733T1 ATE211733T1 AT96109043T AT96109043T ATE211733T1 AT E211733 T1 ATE211733 T1 AT E211733T1 AT 96109043 T AT96109043 T AT 96109043T AT 96109043 T AT96109043 T AT 96109043T AT E211733 T1 ATE211733 T1 AT E211733T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydropyridines
- npy
- antagonists
- piperidine derivatives
- npy antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48235395A | 1995-06-07 | 1995-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE211733T1 true ATE211733T1 (de) | 2002-01-15 |
Family
ID=23915711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96109043T ATE211733T1 (de) | 1995-06-07 | 1996-06-05 | Dihydropyridine als npy-antagonisten: piperidinderivate |
Country Status (10)
Country | Link |
---|---|
US (1) | US5668151A (de) |
EP (1) | EP0747357B1 (de) |
JP (1) | JPH093045A (de) |
AT (1) | ATE211733T1 (de) |
AU (1) | AU720923B2 (de) |
CA (1) | CA2177110A1 (de) |
DE (1) | DE69618383T2 (de) |
DK (1) | DK0747357T3 (de) |
ES (1) | ES2169774T3 (de) |
PT (1) | PT747357E (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU729590B2 (en) * | 1996-10-23 | 2001-02-08 | Sanofi-Aventis | Cosmetic composition containing a neuropeptide Y receptor antagonist |
WO1998035957A1 (en) * | 1997-02-14 | 1998-08-20 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
US6245817B1 (en) | 1997-02-14 | 2001-06-12 | Bayer Corporation | NPY5 receptor antagonists and methods for using same |
US6048900A (en) | 1998-02-13 | 2000-04-11 | Bayer Corporation | Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists |
US6001836A (en) * | 1997-05-28 | 1999-12-14 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: cyanoguanidine derivatives |
US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6525069B1 (en) * | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
DE69926919D1 (de) | 1998-12-18 | 2005-09-29 | Bristol Myers Squibb Pharma Co | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren |
AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
CA2347912A1 (en) | 1998-12-18 | 2000-06-22 | Soo S. Ko | Heterocyclic piperidines as modulators of chemokine receptor activity |
IL142768A0 (en) * | 1998-12-18 | 2002-03-10 | Du Pont Pharm Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6331541B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
AU2482100A (en) * | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
WO2000035876A1 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
EP1140086A4 (de) * | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-ureidoalkylpiperidine als modulatoren der chemokin-rezeptor-aktivität |
US6291476B1 (en) | 1999-05-12 | 2001-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
WO2000078319A1 (en) * | 1999-06-21 | 2000-12-28 | Bristol-Myers Squibb Company | Dihydropyrazine derivatives as npy antagonists |
EP1219605B1 (de) | 1999-10-05 | 2006-05-10 | Takeda Pharmaceutical Company Limited | Harnstoff-verbindungen, ein verfahren zu deren herstellung und ihre verwendung |
WO2001028987A1 (en) * | 1999-10-15 | 2001-04-26 | Du Pont Pharmaceuticals Company | Benzylcycloalkyl amines as modulators of chemokine receptor activity |
CA2386049A1 (en) | 1999-10-15 | 2001-04-26 | Daniel S. Gardner | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
US6784200B2 (en) * | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
US6897234B2 (en) * | 1999-12-17 | 2005-05-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
WO2001053477A1 (en) * | 2000-01-20 | 2001-07-26 | Baylor College Of Medicine | Methods and compositions for control of bone formation via modulation of neuropeptide y activity |
US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
US6479482B2 (en) | 2000-05-10 | 2002-11-12 | Bristol-Myers Squibb Company | Alkylamine derivatives of dihydropyridine NPY antagonists |
US6444675B2 (en) * | 2000-05-10 | 2002-09-03 | Bristol-Myers Squibb Company | 4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists |
US6432960B2 (en) * | 2000-05-10 | 2002-08-13 | Bristol-Myers Squibb Company | Squarate derivatives of dihydropyridine NPY antagonists |
US6391881B2 (en) | 2000-05-19 | 2002-05-21 | Bristol-Myers Squibb Company | Thiourea derivatives of dihydropyridine NPY antagonists |
EP1296949A2 (de) * | 2000-06-21 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Piperidinamide zur verwendung als chemokinin-rezeptor-modulatoren |
CN1440402A (zh) | 2000-06-30 | 2003-09-03 | 布里斯托尔-迈尔斯斯奎布公司 | 作为趋化因子受体活性调节剂的n-脲基杂环烷基-哌啶 |
US6596724B2 (en) | 2000-07-07 | 2003-07-22 | Bristol-Myers Squibb Company | Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists |
WO2003024401A2 (en) * | 2001-09-18 | 2003-03-27 | Bristol-Myers Squibb Company | Piperizinones as modulators of chemokine receptor activity |
CA2461345A1 (en) | 2001-09-24 | 2003-04-03 | Imperial College Innovations Ltd. | Use of pyy or agonist thereof to modify feeding behaviour |
AU2002348131A1 (en) | 2001-12-05 | 2003-06-23 | Baylor College Of Medicine | Methods and compositions for control of bone formation via modulation of sympathetic tone |
TW200409630A (en) * | 2002-09-12 | 2004-06-16 | Bristol Myers Squibb Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
AU2003275257A1 (en) * | 2002-09-26 | 2004-04-19 | Bristol-Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
WO2004043396A2 (en) * | 2002-11-09 | 2004-05-27 | Nobex Corporation | Modified carbamate-containing prodrugs and methods of synthesizing same |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
WO2005049027A2 (en) | 2003-11-03 | 2005-06-02 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
US7291744B2 (en) * | 2003-11-13 | 2007-11-06 | Bristol-Myers Squibb Company | N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity |
WO2005051911A1 (en) * | 2003-11-26 | 2005-06-09 | Novartis Ag | 4-phenylpiperidine derivatives as renin inhibitors |
EP1708703A4 (de) | 2003-12-11 | 2008-04-09 | Anormed Inc | Chemokin-rezeptor-bindende verbindungen |
US7498346B2 (en) | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
EP2089383B1 (de) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
EP2542549B1 (de) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Glutaminylcyclase-hemmer |
EA022420B1 (ru) | 2010-03-10 | 2015-12-30 | Пробиодруг Аг | Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5) |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3523950A (en) * | 1967-12-13 | 1970-08-11 | Robins Co Inc A H | Certain 4 - phenyl - 1,2,3,6 - tetrahydropyridyl-n-lower alkylene-ureas and derivatives |
DE3587851D1 (de) * | 1984-09-28 | 1994-07-21 | Byk Gulden Lomberg Chem Fab | Neue Diarylverbindungen. |
DE3500898A1 (de) * | 1985-01-12 | 1986-07-17 | Hoechst Ag, 6230 Frankfurt | Neue propionsaeureamide mit saeuresekretionshemmender wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
HU196755B (en) * | 1986-09-16 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of new substituated amilid derivatives and medical compositions containing them |
EP0276552A1 (de) * | 1986-12-08 | 1988-08-03 | Yamanouchi Pharmaceutical Co. Ltd. | 1,4-Dihydropyridin-Derivate und ihre Herstellung |
JPH0449237A (ja) * | 1990-06-15 | 1992-02-18 | Yamanouchi Pharmaceut Co Ltd | ホスホリパーゼa↓2阻害剤 |
WO1993006082A1 (en) * | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
GB9119983D0 (en) * | 1991-09-19 | 1991-11-06 | Erba Carlo Spa | Dihydropyridine derivatives useful in antitumor therapy |
FR2701480B1 (fr) * | 1993-02-15 | 1995-05-24 | Sanofi Elf | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
-
1996
- 1996-05-08 US US08/639,968 patent/US5668151A/en not_active Expired - Fee Related
- 1996-05-22 CA CA002177110A patent/CA2177110A1/en not_active Abandoned
- 1996-06-05 DK DK96109043T patent/DK0747357T3/da active
- 1996-06-05 AT AT96109043T patent/ATE211733T1/de not_active IP Right Cessation
- 1996-06-05 DE DE69618383T patent/DE69618383T2/de not_active Expired - Fee Related
- 1996-06-05 EP EP96109043A patent/EP0747357B1/de not_active Expired - Lifetime
- 1996-06-05 ES ES96109043T patent/ES2169774T3/es not_active Expired - Lifetime
- 1996-06-05 PT PT96109043T patent/PT747357E/pt unknown
- 1996-06-06 AU AU54758/96A patent/AU720923B2/en not_active Ceased
- 1996-06-07 JP JP8145272A patent/JPH093045A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US5668151A (en) | 1997-09-16 |
PT747357E (pt) | 2002-06-28 |
AU5475896A (en) | 1996-12-19 |
CA2177110A1 (en) | 1996-12-08 |
EP0747357A2 (de) | 1996-12-11 |
EP0747357A3 (de) | 1998-12-16 |
DE69618383T2 (de) | 2002-09-26 |
EP0747357B1 (de) | 2002-01-09 |
DK0747357T3 (da) | 2002-04-29 |
AU720923B2 (en) | 2000-06-15 |
DE69618383D1 (de) | 2002-02-14 |
JPH093045A (ja) | 1997-01-07 |
ES2169774T3 (es) | 2002-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |