ATE203407T1 - Arzneistoffabgabepräparat, das nikotin oder ein derivat davon und stärkemikrokügelchen enthält, und verfahren für seine herstellung - Google Patents
Arzneistoffabgabepräparat, das nikotin oder ein derivat davon und stärkemikrokügelchen enthält, und verfahren für seine herstellungInfo
- Publication number
- ATE203407T1 ATE203407T1 AT95900330T AT95900330T ATE203407T1 AT E203407 T1 ATE203407 T1 AT E203407T1 AT 95900330 T AT95900330 T AT 95900330T AT 95900330 T AT95900330 T AT 95900330T AT E203407 T1 ATE203407 T1 AT E203407T1
- Authority
- AT
- Austria
- Prior art keywords
- starch
- derivative
- pct
- microbeads
- production
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229960002715 nicotine Drugs 0.000 title abstract 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000012377 drug delivery Methods 0.000 title 1
- 239000011325 microbead Substances 0.000 title 1
- 239000004005 microsphere Substances 0.000 abstract 5
- 229920002472 Starch Polymers 0.000 abstract 4
- 235000019698 starch Nutrition 0.000 abstract 4
- 239000008107 starch Substances 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000208125 Nicotiana Species 0.000 abstract 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9303574A SE9303574D0 (sv) | 1993-11-01 | 1993-11-01 | Composition for drug delivery and method the manufacturing thereof |
| PCT/SE1994/000917 WO1995012399A1 (en) | 1993-11-01 | 1994-10-03 | Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE203407T1 true ATE203407T1 (de) | 2001-08-15 |
Family
ID=20391581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95900330T ATE203407T1 (de) | 1993-11-01 | 1994-10-03 | Arzneistoffabgabepräparat, das nikotin oder ein derivat davon und stärkemikrokügelchen enthält, und verfahren für seine herstellung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5939100A (de) |
| EP (1) | EP0739206B1 (de) |
| JP (1) | JPH09504305A (de) |
| AT (1) | ATE203407T1 (de) |
| AU (1) | AU682228B2 (de) |
| DE (1) | DE69427832T2 (de) |
| DK (1) | DK0739206T3 (de) |
| ES (1) | ES2160689T3 (de) |
| GR (1) | GR3036964T3 (de) |
| NZ (1) | NZ275903A (de) |
| PT (1) | PT739206E (de) |
| SE (1) | SE9303574D0 (de) |
| WO (1) | WO1995012399A1 (de) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2231968A1 (en) * | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US20080138294A1 (en) * | 1999-07-16 | 2008-06-12 | Igor Gonda | Systems and methods for effecting cessation of tobacco use |
| JP4999245B2 (ja) * | 1999-07-16 | 2012-08-15 | アラディグム コーポレイション | 禁煙を達成するためのシステム |
| US8256433B2 (en) * | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US20080138399A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US20080138398A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US6799576B2 (en) * | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| WO2001089476A1 (en) * | 2000-05-19 | 2001-11-29 | Npd Llc | Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| US6951656B2 (en) * | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US7037528B2 (en) * | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6884436B2 (en) * | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6977085B2 (en) * | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| SE0102197D0 (sv) * | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| CN1558755A (zh) | 2001-09-26 | 2004-12-29 | ���ع��ʹ�˾ | 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒 |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| US20030111088A1 (en) * | 2001-10-29 | 2003-06-19 | Addiction Therapies, Inc. | Device and method for treating combination dependencies |
| US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
| US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| US20040091581A1 (en) * | 2002-11-08 | 2004-05-13 | Ghislaine Joly | Starch/collagen casings for co-extruded food products |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| ATE353633T1 (de) * | 2002-12-19 | 2007-03-15 | Pharmacia Corp | Nicht-hygroskopische formulierung, die einen hygroskopischen wirkstoff enthält |
| FI3473251T3 (fi) | 2002-12-20 | 2024-01-09 | Niconovum Ab | Nikotiini-selluloosa-kombinaatio |
| SE0302947D0 (sv) | 2003-01-24 | 2003-11-07 | Magle Ab | A composition material for transmucosal delivery |
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| CA2519287A1 (en) | 2003-03-27 | 2004-10-14 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| CA2526432A1 (en) | 2003-05-21 | 2004-12-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
| DE602004019430D1 (de) * | 2003-09-08 | 2009-03-26 | Mcneil Ab | Nikotinformulierungen und ihre verwendung |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| AU2004289248B2 (en) | 2003-11-07 | 2012-05-03 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| NZ549939A (en) * | 2004-03-19 | 2009-12-24 | Mcneil Ab | Means for transdermal administration of nicotine |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| WO2006016530A1 (ja) | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| WO2006022714A1 (en) | 2004-08-12 | 2006-03-02 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| US8322350B2 (en) * | 2004-12-30 | 2012-12-04 | Philip Morris Usa Inc. | Aerosol generator |
| US8323683B2 (en) | 2005-05-18 | 2012-12-04 | Mcneil-Ppc, Inc. | Flavoring of drug-containing chewing gums |
| CA2609612C (en) | 2005-05-23 | 2014-09-23 | President & Fellows Of Harvard College | Use of huperzine to treat epilepsy |
| CA2646942C (en) | 2006-03-16 | 2014-07-29 | Niconovum Ab | Improved snuff composition |
| US20070269386A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| US20070269492A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| US20100197625A1 (en) | 2006-12-21 | 2010-08-05 | D Alarcao Marc | Synthetic lipophilic inositol glycans for treatment of cancer and glucose-metabolism disorders |
| ES2652415T3 (es) | 2006-12-26 | 2018-02-02 | Shin Nippon Biomedical Laboratories, Ltd. | Preparación para aplicación transnasal |
| US20080216828A1 (en) | 2007-03-09 | 2008-09-11 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| US20080286340A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| US20080286341A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| WO2010028134A2 (en) * | 2008-09-04 | 2010-03-11 | President And Fellows Of Harvard College | Treatment of neurological disorders using huperzine |
| US20100124560A1 (en) * | 2008-11-14 | 2010-05-20 | Mcneil Ab | Multi portion intra-oral dosage form and use thereof |
| EP2233134A1 (de) | 2009-03-27 | 2010-09-29 | McNeil AB | Mehrteilige intraorale Darreichungsform mit organoleptischen Eigenschaften |
| US20100247586A1 (en) * | 2009-03-27 | 2010-09-30 | Andreas Hugerth | Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties |
| EP2429495A4 (de) * | 2009-05-15 | 2014-01-22 | Shin Nippon Biomedical Lab Ltd | Intranasale pharmazeutische zusammensetzung mit verbesserter pharmakokinetik |
| US8827946B2 (en) | 2009-07-31 | 2014-09-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| CA2781593C (en) * | 2009-12-04 | 2018-01-23 | Magle Ab | Microspheres of hydrolysed starch with endogenous, charged ligands |
| US20110182831A1 (en) * | 2010-01-25 | 2011-07-28 | Aradigm Corporation | Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| EP2640190A4 (de) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | Modifizierte nikotinische verbindungen und zugehörige verfahren |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US20140255452A1 (en) | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
| WO2015009913A1 (en) | 2013-07-19 | 2015-01-22 | Altria Client Services Inc. | Methods and systems for incorporating nicotine into oral products |
| EP3033080A4 (de) * | 2013-08-15 | 2017-01-11 | Antivirus Therapeutics | Verfahren und zusammensetzungen zur erhöhung der wirksamkeit von viruziden |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| SE541358C2 (en) | 2017-05-30 | 2019-08-13 | Enorama Pharma Ab | Nicotine-containing chewing gum compositions |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| US12214118B2 (en) | 2018-02-02 | 2025-02-04 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| WO2019239356A1 (en) | 2018-06-15 | 2019-12-19 | R. J. Reynolds Tobacco Company | Purification of nicotine |
| EP4232006A4 (de) * | 2020-12-16 | 2024-05-08 | LIW Innovation AB | Neue pulverzusammensetzung |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US865026A (en) * | 1906-12-15 | 1907-09-03 | Ellis Foster Co | Masticable tobacco preparation. |
| US940521A (en) * | 1909-05-06 | 1909-11-16 | George A Endicott | Wire-stretching appliance. |
| US3901248A (en) * | 1970-07-22 | 1975-08-26 | Leo Ab | Chewable smoking substitute composition |
| US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
| US3845217A (en) * | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
| SE420565B (sv) * | 1974-06-06 | 1981-10-19 | Pharmacia Ab | Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel |
| GB1528391A (en) * | 1976-01-05 | 1978-10-11 | Gildemeister V | Aerosol compositions |
| GB2030862A (en) * | 1978-04-10 | 1980-04-16 | Smith A | A composition for treating drug addiction such as smoking nicotine-containing products |
| GB8301659D0 (en) * | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| AU587863B2 (en) * | 1985-10-07 | 1989-08-31 | Basf Aktiengesellschaft | Vitamin-containing granules and production thereof |
| GB8712176D0 (en) * | 1987-05-22 | 1987-06-24 | Cosmas Damian Ltd | Drug delivery system |
| GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| US4915950A (en) * | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
| SE8904295D0 (sv) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Smoking substitute |
| US5026697A (en) * | 1990-05-30 | 1991-06-25 | Nda International, Inc. | Rapid method for interrupting or attenuating the nicotine/tobacco dependency syndrome |
| US5167242A (en) * | 1990-06-08 | 1992-12-01 | Kabi Pharmacia Aktiebolaq | Nicotine-impermeable container and method of fabricating the same |
| GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
-
1993
- 1993-11-01 SE SE9303574A patent/SE9303574D0/xx unknown
-
1994
- 1994-10-03 PT PT95900330T patent/PT739206E/pt unknown
- 1994-10-03 AT AT95900330T patent/ATE203407T1/de not_active IP Right Cessation
- 1994-10-03 EP EP95900330A patent/EP0739206B1/de not_active Expired - Lifetime
- 1994-10-03 US US08/640,873 patent/US5939100A/en not_active Expired - Lifetime
- 1994-10-03 DE DE69427832T patent/DE69427832T2/de not_active Expired - Lifetime
- 1994-10-03 JP JP7513154A patent/JPH09504305A/ja active Pending
- 1994-10-03 WO PCT/SE1994/000917 patent/WO1995012399A1/en not_active Ceased
- 1994-10-03 DK DK95900330T patent/DK0739206T3/da active
- 1994-10-03 ES ES95900330T patent/ES2160689T3/es not_active Expired - Lifetime
- 1994-10-03 AU AU81184/94A patent/AU682228B2/en not_active Expired
- 1994-10-03 NZ NZ275903A patent/NZ275903A/en not_active IP Right Cessation
-
2001
- 2001-10-22 GR GR20010401834T patent/GR3036964T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3036964T3 (en) | 2002-01-31 |
| DK0739206T3 (da) | 2001-10-01 |
| ES2160689T3 (es) | 2001-11-16 |
| WO1995012399A1 (en) | 1995-05-11 |
| PT739206E (pt) | 2002-01-30 |
| AU682228B2 (en) | 1997-09-25 |
| JPH09504305A (ja) | 1997-04-28 |
| DE69427832D1 (de) | 2001-08-30 |
| NZ275903A (en) | 1998-01-26 |
| SE9303574D0 (sv) | 1993-11-01 |
| DE69427832T2 (de) | 2001-11-22 |
| EP0739206A1 (de) | 1996-10-30 |
| AU8118494A (en) | 1995-05-23 |
| US5939100A (en) | 1999-08-17 |
| EP0739206B1 (de) | 2001-07-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |