SE9303574D0 - Composition for drug delivery and method the manufacturing thereof - Google Patents

Composition for drug delivery and method the manufacturing thereof

Info

Publication number
SE9303574D0
SE9303574D0 SE9303574A SE9303574A SE9303574D0 SE 9303574 D0 SE9303574 D0 SE 9303574D0 SE 9303574 A SE9303574 A SE 9303574A SE 9303574 A SE9303574 A SE 9303574A SE 9303574 D0 SE9303574 D0 SE 9303574D0
Authority
SE
Sweden
Prior art keywords
pct
manufacturing
pharmaceutical composition
around
starch microspheres
Prior art date
Application number
SE9303574A
Other languages
English (en)
Swedish (sv)
Inventor
Sten Albrechtsen
Lene Orup-Jacobsen
Jens Hansen
Birgitte Moellgaard
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Priority to SE9303574A priority Critical patent/SE9303574D0/xx
Publication of SE9303574D0 publication Critical patent/SE9303574D0/xx
Priority to EP95900330A priority patent/EP0739206B1/de
Priority to ES95900330T priority patent/ES2160689T3/es
Priority to AT95900330T priority patent/ATE203407T1/de
Priority to PT95900330T priority patent/PT739206E/pt
Priority to DE69427832T priority patent/DE69427832T2/de
Priority to JP7513154A priority patent/JPH09504305A/ja
Priority to US08/640,873 priority patent/US5939100A/en
Priority to PCT/SE1994/000917 priority patent/WO1995012399A1/en
Priority to CA002173504A priority patent/CA2173504C/en
Priority to NZ275903A priority patent/NZ275903A/en
Priority to DK95900330T priority patent/DK0739206T3/da
Priority to AU81184/94A priority patent/AU682228B2/en
Priority to GR20010401834T priority patent/GR3036964T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SE9303574A 1993-11-01 1993-11-01 Composition for drug delivery and method the manufacturing thereof SE9303574D0 (sv)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SE9303574A SE9303574D0 (sv) 1993-11-01 1993-11-01 Composition for drug delivery and method the manufacturing thereof
AU81184/94A AU682228B2 (en) 1993-11-01 1994-10-03 Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
JP7513154A JPH09504305A (ja) 1993-11-01 1994-10-03 ニコチンまたはその誘導体およびデンプン微小球からなるドラッグデリバリー用組成物およびその製法
ES95900330T ES2160689T3 (es) 1993-11-01 1994-10-03 Composicion para aporte de farmacos que comprende nicotina o un derivado de la misma y microesferas de almidon y metodo para la fabricacion de la misma.
AT95900330T ATE203407T1 (de) 1993-11-01 1994-10-03 Arzneistoffabgabepräparat, das nikotin oder ein derivat davon und stärkemikrokügelchen enthält, und verfahren für seine herstellung
PT95900330T PT739206E (pt) 1993-11-01 1994-10-03 Composicoes para a entrega de medicamentos que compreende nicotina ou um seu derivado e microsferas de amido e um metodo de procedimento
DE69427832T DE69427832T2 (de) 1993-11-01 1994-10-03 Arzneistoffabgabepräparat, das nikotin oder ein derivat davon und stärkemikrokügelchen enthält, und verfahren für seine herstellung
EP95900330A EP0739206B1 (de) 1993-11-01 1994-10-03 Arzneistoffabgabepräparat, das nikotin oder ein derivat davon und stärkemikrokügelchen enthält, und verfahren für seine herstellung
US08/640,873 US5939100A (en) 1993-11-01 1994-10-03 Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
PCT/SE1994/000917 WO1995012399A1 (en) 1993-11-01 1994-10-03 Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
CA002173504A CA2173504C (en) 1993-11-01 1994-10-03 Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
NZ275903A NZ275903A (en) 1993-11-01 1994-10-03 Nicotine bound to starch microspheres in a composition that is suitable for oral or nasal administration by smokers
DK95900330T DK0739206T3 (da) 1993-11-01 1994-10-03 Præparat til afgivelse af lægemiddel indeholdende nikotin eller et derivat deraf og stivelsesmikrokugler, samt fremgangsmåde til fremstilling heraf
GR20010401834T GR3036964T3 (en) 1993-11-01 2001-10-22 Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9303574A SE9303574D0 (sv) 1993-11-01 1993-11-01 Composition for drug delivery and method the manufacturing thereof

Publications (1)

Publication Number Publication Date
SE9303574D0 true SE9303574D0 (sv) 1993-11-01

Family

ID=20391581

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9303574A SE9303574D0 (sv) 1993-11-01 1993-11-01 Composition for drug delivery and method the manufacturing thereof

Country Status (13)

Country Link
US (1) US5939100A (de)
EP (1) EP0739206B1 (de)
JP (1) JPH09504305A (de)
AT (1) ATE203407T1 (de)
AU (1) AU682228B2 (de)
DE (1) DE69427832T2 (de)
DK (1) DK0739206T3 (de)
ES (1) ES2160689T3 (de)
GR (1) GR3036964T3 (de)
NZ (1) NZ275903A (de)
PT (1) PT739206E (de)
SE (1) SE9303574D0 (de)
WO (1) WO1995012399A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2231968A1 (en) * 1998-03-11 1999-09-11 Smoke-Stop, A Partnership Consisting Of Art Slutsky Method of producing a nicotine medicament
US6344222B1 (en) 1998-09-03 2002-02-05 Jsr Llc Medicated chewing gum delivery system for nicotine
US6358060B2 (en) 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US6799576B2 (en) * 1999-07-16 2004-10-05 Aradigm Corporation System for effecting smoking cessation
US20080138399A1 (en) * 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US20080138398A1 (en) * 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US20080138294A1 (en) * 1999-07-16 2008-06-12 Igor Gonda Systems and methods for effecting cessation of tobacco use
AU777326B2 (en) * 1999-07-16 2004-10-14 Aradigm Corporation System for effecting smoke cessation
US8256433B2 (en) * 1999-07-16 2012-09-04 Aradigm Corporation Systems and methods for effecting cessation of tobacco use
AU2001261744A1 (en) * 2000-05-19 2001-12-03 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US7037528B2 (en) * 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
SE0102197D0 (sv) * 2001-06-20 2001-06-20 Pharmacia Ab New product and use and manufacture thereof
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US20030111088A1 (en) * 2001-10-29 2003-06-19 Addiction Therapies, Inc. Device and method for treating combination dependencies
US20030159702A1 (en) * 2002-01-21 2003-08-28 Lindell Katarina E.A. Formulation and use manufacture thereof
US7767698B2 (en) * 2002-06-03 2010-08-03 Mcneil Ab Formulation and use thereof
US20040091581A1 (en) * 2002-11-08 2004-05-13 Ghislaine Joly Starch/collagen casings for co-extruded food products
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1575563B1 (de) * 2002-12-19 2007-02-14 Pharmacia Corporation Nicht-hygroskopische formulierung, die einen hygroskopischen wirkstoff enthält
ES2708551T3 (es) 2002-12-20 2019-04-10 Niconovum Ab Material particulado que contiene nicotina con una celulosa cristalina
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
KR100974482B1 (ko) 2003-03-27 2010-08-10 가부시키가이샤 바이오악티스 비강용 분말 약제 투약 장치
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
CA2537488A1 (en) * 2003-09-08 2005-03-17 Pfizer Health Ab Nicotine formulations and use thereof
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
JP4931596B2 (ja) 2003-11-07 2012-05-16 ユーエス スモークレス タバコ カンパニー リミテッド ライアビリティ カンパニー タバコ組成物
RU2334507C2 (ru) * 2004-03-19 2008-09-27 Макнейл Аб Средство для чрескожного введения никотина
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US8673360B2 (en) * 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
AU2004322756B2 (en) 2004-08-12 2011-04-14 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US8322350B2 (en) 2004-12-30 2012-12-04 Philip Morris Usa Inc. Aerosol generator
US8323683B2 (en) * 2005-05-18 2012-12-04 Mcneil-Ppc, Inc. Flavoring of drug-containing chewing gums
WO2006127748A1 (en) * 2005-05-23 2006-11-30 President & Fellows Of Harvard College Use of huperzine for disorders
EP1998748B1 (de) 2006-03-16 2015-01-14 NicoNovum AB Verbesserte schnupftabakzusammensetzung
US20070269386A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
US20070269492A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
US8642016B2 (en) 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
EP2324837A1 (de) 2006-12-21 2011-05-25 Trustees Of Tufts College Synthetische lipophile Inositolglycane zur Behandlung von Glucosemetabolismusstörungen
ES2652415T3 (es) 2006-12-26 2018-02-02 Shin Nippon Biomedical Laboratories, Ltd. Preparación para aplicación transnasal
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US20080286340A1 (en) * 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
US20080286341A1 (en) * 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered coated nicotine containing products
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US20110224245A1 (en) * 2008-09-04 2011-09-15 President And Fellows Of Harvard College Treatment Of Neurological Disorders Using Huperzine
US20100124560A1 (en) * 2008-11-14 2010-05-20 Mcneil Ab Multi portion intra-oral dosage form and use thereof
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
EP2233134A1 (de) 2009-03-27 2010-09-29 McNeil AB Mehrteilige intraorale Darreichungsform mit organoleptischen Eigenschaften
WO2010131486A1 (en) * 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US8827946B2 (en) * 2009-07-31 2014-09-09 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
HRP20160835T1 (hr) * 2009-12-04 2016-09-23 Magle Ab Mikrosfere hidroliziranog škroba s endogenim, nabijenim ligandima
US20110182831A1 (en) * 2010-01-25 2011-07-28 Aradigm Corporation Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
EA201390660A1 (ru) 2010-11-05 2013-11-29 Селекта Байосайенсиз, Инк. Модифицированные никотиновые соединения и связанные способы
US9084439B2 (en) 2011-09-22 2015-07-21 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9474303B2 (en) 2011-09-22 2016-10-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9629392B2 (en) 2011-09-22 2017-04-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
US9763928B2 (en) 2012-02-10 2017-09-19 Niconovum Usa, Inc. Multi-layer nicotine-containing pharmaceutical composition
US20140255452A1 (en) 2013-03-11 2014-09-11 Niconovum Usa, Inc. Method and apparatus for differentiating oral pouch products
EP3021691B1 (de) 2013-07-19 2019-09-04 Altria Client Services LLC Verfahren und systeme zur einfügung von nikotin in orale produkte
CA2921021C (en) * 2013-08-15 2022-12-13 Antivirus Therapeutics Methods and compositions for increasing the effectiveness of antiviral agents
US20170165252A1 (en) 2015-12-10 2017-06-15 Niconovum Usa Inc. Protein-enriched therapeutic composition
SE541358C2 (en) 2017-05-30 2019-08-13 Enorama Pharma Ab Nicotine-containing chewing gum compositions
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
EP3807260B1 (de) 2018-06-15 2024-09-18 R. J. Reynolds Tobacco Company Reinigung von nikotin
CA3204459A1 (en) * 2020-12-16 2022-06-23 Liw Innovation Ab A new powder composition

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US865026A (en) * 1906-12-15 1907-09-03 Ellis Foster Co Masticable tobacco preparation.
US940521A (en) * 1909-05-06 1909-11-16 George A Endicott Wire-stretching appliance.
US3877468A (en) * 1970-07-22 1975-04-15 Leo Ab Chewable tobacco substitute composition
US3901248A (en) * 1970-07-22 1975-08-26 Leo Ab Chewable smoking substitute composition
US3845217A (en) * 1972-11-16 1974-10-29 Helsingborg L Ab Buffered smoking substitute compositions
SE420565B (sv) * 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
GB1528391A (en) * 1976-01-05 1978-10-11 Gildemeister V Aerosol compositions
GB2030862A (en) * 1978-04-10 1980-04-16 Smith A A composition for treating drug addiction such as smoking nicotine-containing products
GB8301659D0 (en) * 1983-01-21 1983-02-23 Leo Ab Smoking substitutes
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
AU587863B2 (en) * 1985-10-07 1989-08-31 Basf Aktiengesellschaft Vitamin-containing granules and production thereof
GB8712176D0 (en) * 1987-05-22 1987-06-24 Cosmas Damian Ltd Drug delivery system
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
SE8904295D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Smoking substitute
US5026697A (en) * 1990-05-30 1991-06-25 Nda International, Inc. Rapid method for interrupting or attenuating the nicotine/tobacco dependency syndrome
US5167242A (en) * 1990-06-08 1992-12-01 Kabi Pharmacia Aktiebolaq Nicotine-impermeable container and method of fabricating the same
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system

Also Published As

Publication number Publication date
DK0739206T3 (da) 2001-10-01
DE69427832D1 (de) 2001-08-30
AU8118494A (en) 1995-05-23
EP0739206A1 (de) 1996-10-30
AU682228B2 (en) 1997-09-25
PT739206E (pt) 2002-01-30
DE69427832T2 (de) 2001-11-22
WO1995012399A1 (en) 1995-05-11
EP0739206B1 (de) 2001-07-25
ATE203407T1 (de) 2001-08-15
GR3036964T3 (en) 2002-01-31
ES2160689T3 (es) 2001-11-16
NZ275903A (en) 1998-01-26
JPH09504305A (ja) 1997-04-28
US5939100A (en) 1999-08-17

Similar Documents

Publication Publication Date Title
SE9303574D0 (sv) Composition for drug delivery and method the manufacturing thereof
MY137348A (en) Highly selective norepinephrine reuptake inhibitors and methods of using the same
NO954582L (no) Blanding for nasal administrering av nikotin
IL127244A (en) Substituted amines, methods of their preparation and pharmaceutical compositions containing them
MX9703429A (es) Composiciones hermorroidales y metodos de uso.
DK0862416T3 (da) Ikke-polymert indgivelsessystem med forhalet frigørelse
HU9401106D0 (en) Enhanced skin penetration system for imporoved topical delivery of drugs
DE69928554D1 (de) Therapeutische formulierung enthaltende dosierungsform
SI0801564T1 (en) Use of nebivolol as an anti-atherogenic
BG103430A (en) FACTOR Xa INHIBITING HETEROCYCLIC DERIVATIVES
BG104877A (en) N-substituted anminotetralins as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders
ATE424810T1 (de) Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung
UA88270C2 (ru) Фармацевтический препарат и его применение для профилактики удара, диабета
NO304113B1 (no) Krystallinsk tiagabinhydrokloridmonohydrat, farmas°ytisk preparat som omfatter det, og anvendelse derav for fremstilling av et medikament
ATE213633T1 (de) Lamotrigin haltiges arzneimittel
BG105275A (en) Tan-1057 derivatives
CA2340734A1 (en) Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
FR2763592B1 (fr) Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant
HUP9701284A2 (hu) 2,3-Benzodiazepin-származékok felhasználása az endogén opioid rendszerrel összefüggő betegségek és állapotok kezelésére, és megelőzésére alkalmas gyógyászati készítmények előállítására
EA200200914A1 (ru) Система контроля дозирования для однократного ежедневного приема назначенного ципрофлоксацина
SE9403905D0 (sv) New formulations
EP0856519A3 (de) Antibakterielles Insektenprotein
ATE256134T1 (de) Sulfatierte phosphatidylinositole, ihre herstellung und verwendung
CA2173504A1 (en) Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
FR2751967B1 (fr) Agents antipaludeens et antibabesioses et compositions pharmaceutiques les contenant