ATE203024T1 - Heterozyklische verbindungen, ihre herstellung und verwendung - Google Patents

Heterozyklische verbindungen, ihre herstellung und verwendung

Info

Publication number
ATE203024T1
ATE203024T1 AT94117576T AT94117576T ATE203024T1 AT E203024 T1 ATE203024 T1 AT E203024T1 AT 94117576 T AT94117576 T AT 94117576T AT 94117576 T AT94117576 T AT 94117576T AT E203024 T1 ATE203024 T1 AT E203024T1
Authority
AT
Austria
Prior art keywords
stands
optionally substituted
ring
hydrogen atom
hydrocarbon residue
Prior art date
Application number
AT94117576T
Other languages
German (de)
English (en)
Inventor
Hideaki Natsugari
Takenori Ishimaru
Takayuki Doi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE203024T1 publication Critical patent/ATE203024T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT94117576T 1993-11-10 1994-11-08 Heterozyklische verbindungen, ihre herstellung und verwendung ATE203024T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP28117893 1993-11-10
JP33748893 1993-12-28
JP3363794 1994-03-03
JP13855194 1994-06-21

Publications (1)

Publication Number Publication Date
ATE203024T1 true ATE203024T1 (de) 2001-07-15

Family

ID=27459814

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94117576T ATE203024T1 (de) 1993-11-10 1994-11-08 Heterozyklische verbindungen, ihre herstellung und verwendung

Country Status (16)

Country Link
US (1) US5585385A (index.php)
EP (1) EP0652218B1 (index.php)
KR (1) KR950014108A (index.php)
CN (1) CN1052004C (index.php)
AT (1) ATE203024T1 (index.php)
AU (1) AU678295B2 (index.php)
BR (1) BR9404403A (index.php)
CA (1) CA2135440A1 (index.php)
DE (1) DE69427675T2 (index.php)
FI (1) FI945281A7 (index.php)
HU (1) HUT68810A (index.php)
IL (1) IL111590A0 (index.php)
NO (1) NO301764B1 (index.php)
NZ (1) NZ264887A (index.php)
RU (1) RU2135471C1 (index.php)
TW (1) TW263498B (index.php)

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US6727258B2 (en) * 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
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WO2000023443A1 (en) * 1998-10-22 2000-04-27 Akzo Nobel N.V. Tetrahydropyridopyridine derivatives and intermediates for producing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
AU5451400A (en) 1999-06-04 2000-12-28 Merck & Co., Inc. Thrombin inhibitors
US20040152727A1 (en) * 2001-05-18 2004-08-05 Hay Douglas William Pierre Novel use
WO2003050123A1 (en) * 2001-12-10 2003-06-19 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyridine derivatives as tachykinin receptor antagonists
JP4417720B2 (ja) 2002-01-18 2010-02-17 杏林製薬株式会社 縮合二環式ピリミジン誘導体
US7402595B2 (en) * 2002-02-13 2008-07-22 Takeda Pharmaceutical Company Limited JNK inhibitor
ATE409187T1 (de) * 2002-03-15 2008-10-15 Merck & Co Inc N-(substituierte benzyl)-8-hydroxy-1,6- naphthyridin-7- carbonsäureamide als hiv- integrase-hemmer
KR20040099367A (ko) * 2002-03-26 2004-11-26 교린 세이야꾸 가부시키 가이샤 타키키닌 수용체 길항제로서의 축합 바이사이클릭 피리딘 유도체
CA2509233A1 (en) * 2002-12-13 2004-07-01 Neurogen Corporation 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
WO2005030792A2 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Quinoline potassium channel inhibitors
CA2539541C (en) * 2003-09-23 2010-06-29 Merck & Co., Inc. Isoquinolinone potassium channel inhibitors
CA2552965A1 (en) * 2004-01-14 2005-07-28 Takeda Pharmaceutical Company Limited Carboxamide derivative and use thereof
KR100781704B1 (ko) * 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR056048A1 (es) * 2005-09-01 2007-09-12 Tanabe Seiyaku Co Compuesto tiomorfolina y procedimiento para preparar el mismo
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида
ES2786298T3 (es) * 2011-03-03 2020-10-09 Zalicus Pharmaceuticals Ltd Inhibidores de benzimidazol del canal de sodio
CN102358730A (zh) * 2011-08-24 2012-02-22 济南赛文医药技术有限公司 一种小分子mek蛋白激酶抑制剂
WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
EP2920183B1 (en) 2012-11-14 2017-03-08 Glaxosmithkline LLC Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors
US10131657B2 (en) * 2013-06-28 2018-11-20 Abbvie Inc. Bromodomain inhibitors
MX385788B (es) 2015-03-04 2025-03-18 Vanda Pharmaceuticals Inc Método de tratamiento con tradipitant.
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
UA124764C2 (uk) 2016-04-15 2021-11-17 Еббві Інк. Інгібітори бромодомену
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
WO2019055225A1 (en) 2017-09-13 2019-03-21 Vanda Pharmaceuticals Inc. ENHANCED TREATMENT OF ATOPIC DERMATITIS USING TRADIPITANT
KR20230012616A (ko) 2020-05-20 2023-01-26 에이엠오 아일랜드 광학 활성 장치에 사용하기 위한 아자쿠마린 및 아자티오쿠마린 유도체
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
EP4620469A3 (en) 2020-07-02 2025-10-01 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
CN119173514A (zh) 2022-03-17 2024-12-20 因赛特公司 作为jak2 v617f抑制剂的三环脲化合物

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HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
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Also Published As

Publication number Publication date
AU678295B2 (en) 1997-05-22
CA2135440A1 (en) 1995-05-11
EP0652218B1 (en) 2001-07-11
CN1052004C (zh) 2000-05-03
NO944252D0 (no) 1994-11-08
RU94040174A (ru) 1996-10-10
KR950014108A (ko) 1995-06-15
BR9404403A (pt) 1995-07-18
DE69427675T2 (de) 2002-05-16
FI945281L (fi) 1995-05-11
HUT68810A (en) 1995-05-19
AU7773894A (en) 1995-05-18
CN1107476A (zh) 1995-08-30
IL111590A0 (en) 1995-01-24
NO944252L (no) 1995-05-11
NZ264887A (en) 1996-12-20
RU2135471C1 (ru) 1999-08-27
FI945281A7 (fi) 1995-05-11
FI945281A0 (fi) 1994-11-09
US5585385A (en) 1996-12-17
EP0652218A1 (en) 1995-05-10
TW263498B (index.php) 1995-11-21
HU9403230D0 (en) 1995-01-30
NO301764B1 (no) 1997-12-08
DE69427675D1 (de) 2001-08-16

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties