ATE191452T1 - Dichtgepackte polykationische ammonium, sulfonium und phosphonium lipide - Google Patents
Dichtgepackte polykationische ammonium, sulfonium und phosphonium lipideInfo
- Publication number
- ATE191452T1 ATE191452T1 AT95905957T AT95905957T ATE191452T1 AT E191452 T1 ATE191452 T1 AT E191452T1 AT 95905957 T AT95905957 T AT 95905957T AT 95905957 T AT95905957 T AT 95905957T AT E191452 T1 ATE191452 T1 AT E191452T1
- Authority
- AT
- Austria
- Prior art keywords
- sulfonium
- tightly packed
- polycationic ammonium
- phosphonium
- packed polycationic
- Prior art date
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 title abstract 2
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 title abstract 2
- 150000004714 phosphonium salts Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940124447 delivery agent Drugs 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 phosphonium lipid compounds Chemical class 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/12—Sulfonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5449—Polyphosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5463—Compounds of the type "quasi-phosphonium", e.g. (C)a-P-(Y)b wherein a+b=4, b>=1 and Y=heteroatom, generally N or O
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/829—Alcaligenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/171,232 US5674908A (en) | 1993-12-20 | 1993-12-20 | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
PCT/US1994/014475 WO1995017373A1 (en) | 1993-12-20 | 1994-12-14 | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE191452T1 true ATE191452T1 (de) | 2000-04-15 |
Family
ID=22623027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95905957T ATE191452T1 (de) | 1993-12-20 | 1994-12-14 | Dichtgepackte polykationische ammonium, sulfonium und phosphonium lipide |
Country Status (8)
Country | Link |
---|---|
US (8) | US5674908A (de) |
EP (1) | EP0741689B1 (de) |
JP (1) | JPH09510435A (de) |
AT (1) | ATE191452T1 (de) |
AU (1) | AU693507B2 (de) |
CA (1) | CA2179611A1 (de) |
DE (1) | DE69423915T2 (de) |
WO (1) | WO1995017373A1 (de) |
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-
1993
- 1993-12-20 US US08/171,232 patent/US5674908A/en not_active Expired - Lifetime
-
1994
- 1994-12-14 AU AU14372/95A patent/AU693507B2/en not_active Ceased
- 1994-12-14 DE DE69423915T patent/DE69423915T2/de not_active Expired - Lifetime
- 1994-12-14 WO PCT/US1994/014475 patent/WO1995017373A1/en active IP Right Grant
- 1994-12-14 AT AT95905957T patent/ATE191452T1/de active
- 1994-12-14 CA CA002179611A patent/CA2179611A1/en not_active Abandoned
- 1994-12-14 EP EP95905957A patent/EP0741689B1/de not_active Expired - Lifetime
- 1994-12-14 JP JP7517507A patent/JPH09510435A/ja not_active Withdrawn
-
1997
- 1997-01-13 US US08/782,783 patent/US5834439A/en not_active Expired - Lifetime
-
1998
- 1998-11-06 US US09/187,676 patent/US6110916A/en not_active Expired - Lifetime
-
2000
- 2000-08-25 US US09/648,492 patent/US6399663B1/en not_active Expired - Lifetime
-
2002
- 2002-04-23 US US10/131,539 patent/US6716882B2/en not_active Expired - Fee Related
-
2004
- 2004-01-21 US US10/762,914 patent/US7501542B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/931,075 patent/US20080207776A1/en not_active Abandoned
-
2009
- 2009-05-21 US US12/470,285 patent/US20090317908A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0741689B1 (de) | 2000-04-05 |
US20040152770A1 (en) | 2004-08-05 |
US20090317908A1 (en) | 2009-12-24 |
EP0741689A1 (de) | 1996-11-13 |
US6110916A (en) | 2000-08-29 |
US20080207776A1 (en) | 2008-08-28 |
WO1995017373A1 (en) | 1995-06-29 |
US6399663B1 (en) | 2002-06-04 |
US6716882B2 (en) | 2004-04-06 |
US5674908A (en) | 1997-10-07 |
JPH09510435A (ja) | 1997-10-21 |
US7501542B2 (en) | 2009-03-10 |
DE69423915T2 (de) | 2000-10-12 |
AU1437295A (en) | 1995-07-10 |
CA2179611A1 (en) | 1995-06-29 |
AU693507B2 (en) | 1998-07-02 |
US20020156049A1 (en) | 2002-10-24 |
DE69423915D1 (de) | 2000-05-11 |
US5834439A (en) | 1998-11-10 |
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