ATE186545T1 - Hydroxyalkylammonium-pyrimidine und purine und nukleosidderivate zur inhibierung entzündlicher cytokine - Google Patents
Hydroxyalkylammonium-pyrimidine und purine und nukleosidderivate zur inhibierung entzündlicher cytokineInfo
- Publication number
- ATE186545T1 ATE186545T1 AT95924641T AT95924641T ATE186545T1 AT E186545 T1 ATE186545 T1 AT E186545T1 AT 95924641 T AT95924641 T AT 95924641T AT 95924641 T AT95924641 T AT 95924641T AT E186545 T1 ATE186545 T1 AT E186545T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxyalkylammonium
- purines
- pyrimidines
- nucleoside derivatives
- inflammatory cytokine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/264,026 US5550132A (en) | 1994-06-22 | 1994-06-22 | Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE186545T1 true ATE186545T1 (de) | 1999-11-15 |
Family
ID=23004241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95924641T ATE186545T1 (de) | 1994-06-22 | 1995-06-21 | Hydroxyalkylammonium-pyrimidine und purine und nukleosidderivate zur inhibierung entzündlicher cytokine |
Country Status (11)
Country | Link |
---|---|
US (2) | US5550132A (de) |
EP (1) | EP0766691B1 (de) |
JP (1) | JPH10509416A (de) |
AT (1) | ATE186545T1 (de) |
AU (1) | AU2906795A (de) |
CA (1) | CA2193645A1 (de) |
DE (1) | DE69513285D1 (de) |
FI (1) | FI965140A (de) |
HU (1) | HUT76332A (de) |
NO (1) | NO965520L (de) |
WO (1) | WO1995035304A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5739109A (en) * | 1988-12-16 | 1998-04-14 | Advanced Immunit Inc. | Method of treating neuroinflammatory degenerative diseases |
US7772432B2 (en) | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
DE19516247A1 (de) * | 1995-05-03 | 1996-11-07 | Albrecht Prof Dr Wendel | Pyrogen-Untersuchungsverfahren |
US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
PL186769B1 (pl) * | 1995-09-07 | 2004-02-27 | Oreal | Zastosowanie wyciągu z Iridaceae i kompozycja zawierająca taki wyciąg |
FR2746647B1 (fr) * | 1996-03-27 | 1998-05-15 | Oreal | Composition apaisante comprenant un extrait d'iridacee |
GB9615202D0 (en) * | 1996-07-19 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
CA2271767A1 (en) | 1996-11-19 | 1998-05-28 | Nathan B. Mantlo | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents |
US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
US6096753A (en) | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
NZ502752A (en) * | 1997-07-15 | 2001-01-26 | Japan Energy Corp | Purine derivatives and their use in the treatment of nephritis |
US5998386A (en) * | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
PT1117653E (pt) | 1998-10-01 | 2003-06-30 | Astrazeneca Ab | Derivados de quinolina e quinazolina e sua utilizacao como inibidores de doencas mediadas pela citosina |
DK1163237T3 (da) | 1999-03-17 | 2004-08-02 | Astrazeneca Ab | Amidderivater |
GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
US6280633B1 (en) | 1999-12-01 | 2001-08-28 | Fantom Technologies Inc. | Ozone sensor and method for use of same in water purification system |
EP1277747A4 (de) * | 2000-03-28 | 2009-07-29 | Michio Ishibashi | Selektive vorsorge- und heilmittel zur behandlung progressiver schäden bei organverletzungen |
ES2381775T3 (es) | 2000-08-04 | 2012-05-31 | Dmi Biosciences, Inc. | Procedimiento del uso de dicetopiperazinas y composición que las contiene |
WO2004030522A2 (en) * | 2002-10-02 | 2004-04-15 | Dmi Biosciences, Inc. | Diagnosis and monitoring of diseases |
AU2004241101B2 (en) | 2003-05-15 | 2010-05-13 | Ampio Pharmaceuticals, Inc. | Treatment of T-cell mediated diseases |
US7745227B2 (en) * | 2003-08-12 | 2010-06-29 | Lawrence Livermore National Security, Llc | System for analysis of explosives |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
US20060086388A1 (en) * | 2004-10-27 | 2006-04-27 | Blake Fye | Venting device for degassing a flow of liquid in a closed system |
US8217047B2 (en) * | 2008-05-27 | 2012-07-10 | Dmi Acquisition Corp. | Therapeutic methods and compounds |
WO2012033792A2 (en) | 2010-09-07 | 2012-03-15 | Dmi Acquisition Corp. | Treatment of diseases |
JP2014530063A (ja) | 2011-10-10 | 2014-11-17 | アンピオ ファーマシューティカルズ,インコーポレイテッド | 免疫寛容が高められた埋込み型医療用デバイス、ならびに製造方法および埋込み方法 |
WO2013055734A1 (en) | 2011-10-10 | 2013-04-18 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
AU2012328605B9 (en) | 2011-10-28 | 2017-08-03 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
SG11201506267XA (en) | 2013-03-15 | 2015-09-29 | Ampio Pharmaceuticals Inc | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
CA2958080A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
EP3310375A4 (de) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | Verwendung von niedermolekularen fraktionen von humanem serumalbumin bei der behandlung von erkrankungen |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
JPS60181075A (ja) * | 1984-02-28 | 1985-09-14 | Shoichiro Ozaki | ピリミジン類,その製法およびその利用法 |
DK163128C (da) * | 1986-08-12 | 1992-06-15 | Hoffmann La Roche | Pyrimidinnucleosider, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende pyrimidinnucleosiderne og anvendelse af pyrimidinnucleosiderne |
GB8926611D0 (en) * | 1989-11-24 | 1990-01-17 | Xenova Ltd | Compound and its use |
US5362732A (en) * | 1989-12-20 | 1994-11-08 | University Of North Carolina At Chapel Hill | Boronated compounds |
US5130302A (en) * | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
ATE161179T1 (de) * | 1991-04-05 | 1998-01-15 | Wisconsin Alumni Res Found | Verwendung von substanzen zur verhütung von endotoxinschock |
US5306722A (en) * | 1992-09-02 | 1994-04-26 | Bristol-Myers Squibb Company | Thymidine derivatives and therapeutic method of use |
-
1994
- 1994-06-22 US US08/264,026 patent/US5550132A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/476,704 patent/US5679684A/en not_active Expired - Fee Related
- 1995-06-21 WO PCT/US1995/007896 patent/WO1995035304A1/en active IP Right Grant
- 1995-06-21 AU AU29067/95A patent/AU2906795A/en not_active Abandoned
- 1995-06-21 CA CA002193645A patent/CA2193645A1/en not_active Abandoned
- 1995-06-21 DE DE69513285T patent/DE69513285D1/de not_active Expired - Lifetime
- 1995-06-21 JP JP8502585A patent/JPH10509416A/ja active Pending
- 1995-06-21 HU HU9603535A patent/HUT76332A/hu unknown
- 1995-06-21 AT AT95924641T patent/ATE186545T1/de not_active IP Right Cessation
- 1995-06-21 EP EP95924641A patent/EP0766691B1/de not_active Expired - Lifetime
-
1996
- 1996-12-20 NO NO965520A patent/NO965520L/no unknown
- 1996-12-20 FI FI965140A patent/FI965140A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1995035304A1 (en) | 1995-12-28 |
EP0766691A1 (de) | 1997-04-09 |
EP0766691B1 (de) | 1999-11-10 |
AU2906795A (en) | 1996-01-15 |
HUT76332A (en) | 1997-08-28 |
HU9603535D0 (en) | 1997-02-28 |
CA2193645A1 (en) | 1995-12-28 |
FI965140A0 (fi) | 1996-12-20 |
JPH10509416A (ja) | 1998-09-14 |
US5679684A (en) | 1997-10-21 |
FI965140A (fi) | 1996-12-20 |
US5550132A (en) | 1996-08-27 |
DE69513285D1 (de) | 1999-12-16 |
NO965520L (no) | 1997-02-21 |
NO965520D0 (no) | 1996-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE186545T1 (de) | Hydroxyalkylammonium-pyrimidine und purine und nukleosidderivate zur inhibierung entzündlicher cytokine | |
DK0767793T3 (da) | N-substituerede-(dihydroxyboryl)alkylderivater af purin, indol og pyrimidin, som er nyttige som inhibitorer af inflammatoriske cytokiner | |
EA199801047A1 (ru) | Замешенные призводные инлазола и их применение в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и фактора некроза опухоли (фно) | |
DK1070056T3 (da) | Phthalazinon-PDE III/IV-inhibitorer | |
GR3026231T3 (en) | 3-aminopiperidine derivatives and related nitrogen containing heterocycles. | |
DK0679160T3 (da) | Pyrimidinnucleotidpræcursorer til behandling af inflammatorisk hepatitis | |
AU2003248978A1 (en) | Fused heteroaryl derivatives for use as p38 kinase inhibitors in the treatment of i.a. rheumatoid arthristis | |
DK1123296T3 (da) | Pyrazolopyrimidinon cGMP PDE5-inhibitorer til behandling af seksuel forstyrrelse | |
AU3564193A (en) | Method of inhibiting the activity of leukocyte derived cytokines | |
CA2299399A1 (en) | Benzenesulfonamide inhibitors of pde-iv and their therapeutic use | |
DK0944616T3 (da) | Bicykliske arylcarboxamider og deres terapeutiske anvendelse | |
NO922524D0 (no) | Pyrimidinderivater, deres fremstilling og anvendelse | |
ES547856A0 (es) | Procedimiento de preparar derivados de nucleosidos y purinas8-substituidos | |
DK0579968T3 (da) | 4-Iminoquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse | |
DK1068209T3 (da) | Fremgangsmåde til fremstilling af purinderivater og deres mellemprodukter | |
MX9706014A (es) | Derivados de xanteno y acridina y su empleo. | |
BR0309135A (pt) | Derivados de ácido hidroxâmico | |
EA200100065A1 (ru) | Производные гидроксамовой кислоты как ингибиторы продуцирования cd23 человека и высвобождения tnf | |
DK0440324T3 (da) | Substiturede alfa-diketoner og deres anvendelse til behandling af inflammatorisk tarmsygdom | |
PT1294729E (pt) | 2-aminoalquil-tieno[2,3-d]pirimidinas | |
FI971177A (fi) | Bisyklisiä karboksiamideja 5-HT1A-antagonisteina | |
IL72681A0 (en) | 4-alkylimidazole derivatives,their preparation and their use as nitrification inhibitors | |
IL169334A0 (en) | Phthalazine derivatives as phosphodiesterase 4 inhibitors | |
WO2005021489A3 (en) | Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors | |
CA2272138A1 (en) | Pyrazolopyrimidine and pyrazolopyridine compounds having crf antagonist activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |