CA2272138A1 - Pyrazolopyrimidine and pyrazolopyridine compounds having crf antagonist activity - Google Patents
Pyrazolopyrimidine and pyrazolopyridine compounds having crf antagonist activity Download PDFInfo
- Publication number
- CA2272138A1 CA2272138A1 CA002272138A CA2272138A CA2272138A1 CA 2272138 A1 CA2272138 A1 CA 2272138A1 CA 002272138 A CA002272138 A CA 002272138A CA 2272138 A CA2272138 A CA 2272138A CA 2272138 A1 CA2272138 A1 CA 2272138A1
- Authority
- CA
- Canada
- Prior art keywords
- antagonist activity
- pyrazolopyrimidine
- crf
- crf antagonist
- pyrazolopyridine compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940122010 Corticotropin releasing factor antagonist Drugs 0.000 title 1
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical compound C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
- 239000002769 corticotropin releasing factor antagonist Substances 0.000 title 1
- 150000005229 pyrazolopyridines Chemical class 0.000 title 1
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 3
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 3
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Disclosed are compounds of the formula:
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99222592A | 1992-12-17 | 1992-12-17 | |
| US07/992,225 | 1992-12-17 | ||
| CA002150483A CA2150483C (en) | 1992-12-17 | 1993-11-03 | Pyrazoles and pyrazolopyrimidines |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002150483A Division CA2150483C (en) | 1992-12-17 | 1993-11-03 | Pyrazoles and pyrazolopyrimidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2272138A1 true CA2272138A1 (en) | 1994-06-23 |
| CA2272138C CA2272138C (en) | 2002-03-05 |
Family
ID=25677980
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002272136A Expired - Fee Related CA2272136C (en) | 1992-12-17 | 1993-11-03 | Pyrazole derivatives having crf antagonist activity |
| CA002272138A Expired - Fee Related CA2272138C (en) | 1992-12-17 | 1993-11-03 | Pyrazolopyrimidine and pyrazolopyridine compounds having crf antagonist activity |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002272136A Expired - Fee Related CA2272136C (en) | 1992-12-17 | 1993-11-03 | Pyrazole derivatives having crf antagonist activity |
Country Status (1)
| Country | Link |
|---|---|
| CA (2) | CA2272136C (en) |
-
1993
- 1993-11-03 CA CA002272136A patent/CA2272136C/en not_active Expired - Fee Related
- 1993-11-03 CA CA002272138A patent/CA2272138C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2272136A1 (en) | 1994-06-23 |
| CA2272136C (en) | 2004-12-07 |
| CA2272138C (en) | 2002-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |