CA2036977A1 - Imidazopyridazines, their production and use - Google Patents

Imidazopyridazines, their production and use

Info

Publication number
CA2036977A1
CA2036977A1 CA002036977A CA2036977A CA2036977A1 CA 2036977 A1 CA2036977 A1 CA 2036977A1 CA 002036977 A CA002036977 A CA 002036977A CA 2036977 A CA2036977 A CA 2036977A CA 2036977 A1 CA2036977 A1 CA 2036977A1
Authority
CA
Canada
Prior art keywords
substituent
group optionally
integer
lower alkyl
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002036977A
Other languages
French (fr)
Other versions
CA2036977C (en
Inventor
Akio Miyake
Yasuko Ashida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CA2036977A1 publication Critical patent/CA2036977A1/en
Application granted granted Critical
Publication of CA2036977C publication Critical patent/CA2036977C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An imidazo [1,2-b]pyridazine compound of the formula (I):
wherein R1 is a halogen atom or a lower alkyl group optionally having substituent(s), R2 and R3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R2 and R3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O)k (k is zero to two), a group
CA002036977A 1990-03-01 1991-02-25 Imidazopyridazines, their production and use Expired - Fee Related CA2036977C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP51072/1990 1990-03-01
JP5107290 1990-03-01
JP41868290 1990-12-28
JP418682/1990 1990-12-28

Publications (2)

Publication Number Publication Date
CA2036977A1 true CA2036977A1 (en) 1991-09-02
CA2036977C CA2036977C (en) 2001-10-16

Family

ID=26391598

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002036977A Expired - Fee Related CA2036977C (en) 1990-03-01 1991-02-25 Imidazopyridazines, their production and use

Country Status (6)

Country Link
US (1) US5145850A (en)
EP (1) EP0444549B1 (en)
JP (1) JP3040182B2 (en)
AT (1) ATE117690T1 (en)
CA (1) CA2036977C (en)
DE (1) DE69106902T2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
TW211013B (en) * 1991-12-27 1993-08-11 Takeda Pharm Industry Co Ltd
ATE174916T1 (en) * 1992-03-18 1999-01-15 Takeda Chemical Industries Ltd IMIDAZOPYRIDAZINE AS ANTIASTHMATICS
US5482939A (en) * 1992-03-18 1996-01-09 Takeda Chemical Industries, Ltd. Triazolopyridazine compounds, their production and use
LT3200B (en) * 1992-03-18 1995-03-27 Takeda Chemical Industries Ltd Triazolopyridazine methodfor production thereof and use
EP0600847B2 (en) * 1992-11-26 2001-10-31 The Procter & Gamble Company Cleaning compositions with combined highly hydrophilic and highly hydrophobic nonionic surfactants
ATE168376T1 (en) * 1993-04-12 1998-08-15 Takeda Chemical Industries Ltd TRIAZOLOPYRIDAZINE DERIVATIVES, THEIR PREPARATION AND USE
TW304878B (en) * 1993-09-21 1997-05-11 Takeda Pharm Industry Co Ltd
AU7079998A (en) 1997-04-25 1998-11-24 Takeda Chemical Industries Ltd. Condensed pyridazine derivatives, their production and use
US6610694B1 (en) 1998-10-06 2003-08-26 Takeda Chemical Industries, Ltd. Condensed pyridazine compounds, their production and use
US6627630B1 (en) 1998-10-21 2003-09-30 Takeda Chemical Industries, Ltd. Condensed pyridazine derivatives, their production and use
EA027573B1 (en) 2005-12-23 2017-08-31 Ариад Фармасьютикалз, Инк. Bicyclic heteroaryl compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464372A (en) * 1982-08-16 1984-08-07 Schering Corporation Imidazo[1,2-b]pyridazines
NO165842C (en) * 1984-04-23 1991-04-17 Takeda Chemical Industries Ltd ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE CEFEM COMPOUNDS.
EP0203271B1 (en) * 1985-03-01 1993-05-26 Takeda Chemical Industries, Ltd. Antibacterial compounds, their production and use
DE3542661A1 (en) * 1985-12-03 1987-06-04 Bayer Ag IMIDAZOPYRIDAZINALKENSAEUREAMIDE, METHOD FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use

Also Published As

Publication number Publication date
EP0444549A1 (en) 1991-09-04
ATE117690T1 (en) 1995-02-15
CA2036977C (en) 2001-10-16
EP0444549B1 (en) 1995-01-25
DE69106902D1 (en) 1995-03-09
JPH04211084A (en) 1992-08-03
US5145850A (en) 1992-09-08
DE69106902T2 (en) 1995-07-06
JP3040182B2 (en) 2000-05-08

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Legal Events

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