ATE181567T1 - Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davon - Google Patents
Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davonInfo
- Publication number
- ATE181567T1 ATE181567T1 AT92922597T AT92922597T ATE181567T1 AT E181567 T1 ATE181567 T1 AT E181567T1 AT 92922597 T AT92922597 T AT 92922597T AT 92922597 T AT92922597 T AT 92922597T AT E181567 T1 ATE181567 T1 AT E181567T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- high purity
- producing high
- subjecting
- fatty acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- -1 C20 fatty acids Chemical class 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 235000019197 fats Nutrition 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000004508 fractional distillation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/08—Refining
- C11C1/10—Refining by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
- C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/10—Refining fats or fatty oils by adsorption
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/12—Refining fats or fatty oils by distillation
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/08—Refining
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28168691A JP3400466B2 (ja) | 1991-10-28 | 1991-10-28 | 高純度エイコサペンタエン酸またはそのエステルの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE181567T1 true ATE181567T1 (de) | 1999-07-15 |
Family
ID=17642575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92922597T ATE181567T1 (de) | 1991-10-28 | 1992-10-28 | Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davon |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5840944A (de) |
| EP (1) | EP0610506B1 (de) |
| JP (1) | JP3400466B2 (de) |
| AT (1) | ATE181567T1 (de) |
| AU (1) | AU664866B2 (de) |
| CA (1) | CA2122345C (de) |
| DE (1) | DE69229480T2 (de) |
| DK (1) | DK0610506T3 (de) |
| ES (1) | ES2132133T3 (de) |
| NO (1) | NO302038B1 (de) |
| WO (1) | WO1993009210A1 (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0697034T3 (da) * | 1993-04-29 | 1997-07-14 | Norsk Hydro As | Fremgangsmåder til kromatografisk fraktionering af fedtsyrer og deres derivater |
| ES2195175T3 (es) | 1996-10-11 | 2003-12-01 | Scarista Ltd | Preparacion farmaceutica que comprende acido eicosapentaenoico y/o acido estearidonico. |
| JP2872986B1 (ja) * | 1998-01-21 | 1999-03-24 | 池田食研株式会社 | 高純度高度不飽和脂肪酸の低級アルコールエステル精製方法 |
| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| WO2000050547A1 (en) | 1999-02-26 | 2000-08-31 | Monsanto Company | Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides |
| ES2159257B1 (es) * | 1999-11-19 | 2002-04-16 | Kd Iqa S L | Nuevo procedimiento de preparacion del ester etilico del acido eicosa pentaenoico. |
| EP1125914A1 (de) | 2000-02-14 | 2001-08-22 | Nisshin Flour Milling Co., Ltd. | Verfahren zur Reinigung und Abtrennung von Eicosapentaencarbonsäure oder ihrer Ester |
| FR2833006A1 (fr) | 2001-11-30 | 2003-06-06 | Cognis France Sa | Procede de preparation d'ester methylique d'acide oleique industriel |
| JP4109893B2 (ja) * | 2002-04-24 | 2008-07-02 | 株式会社日本触媒 | アジリジン類およびｎ−ビニルアミド類の製造方法 |
| ITMI20030573A1 (it) * | 2003-03-24 | 2004-09-25 | Nikem Research Srl | Composti ad azione nootropica, loro preparazione, |
| WO2007149577A2 (en) * | 2006-06-23 | 2007-12-27 | The Procter & Gamble Company | Concentrated and odorless omega 3 fatty acids |
| KR101357298B1 (ko) * | 2008-06-20 | 2014-01-28 | 에이케이 앤 엠엔 바이오팜 주식회사 | 오메가-3계 고도불포화 지방산의 고순도 정제방법 |
| PT2334295T (pt) | 2008-09-02 | 2017-09-15 | Amarin Pharmaceuticals Ie Ltd | Composição farmacêutica compreendendo ácido eicosapentanoico e ácido nicotínico e métodos de utilização dos mesmos |
| US8293727B2 (en) | 2009-02-10 | 2012-10-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| CN107233337A (zh) | 2009-04-29 | 2017-10-10 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| SI2424356T1 (en) | 2009-04-29 | 2018-01-31 | Armarin Pharmaceuticals Ireland Limited | A stable pharmaceutical composition and procedures for its use |
| WO2010147994A1 (en) | 2009-06-15 | 2010-12-23 | Amarin Pharma, Inc. | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
| MX2012003555A (es) * | 2009-09-23 | 2012-07-03 | Amarin Corp Plc | Composicion farmaceutica que comprende acido graso omega-3 y derivado hidroxi de una estatina y metodos para usar la misma. |
| ES2459951T3 (es) * | 2009-12-30 | 2014-05-13 | Basf Pharma (Callanish) Limited | Proceso de separación cromatográfico de lecho móvil simulado para la purificación de ácidos grasos poliinsaturados |
| EP2542060B1 (de) * | 2010-03-04 | 2019-10-02 | Amarin Pharmaceuticals Ireland Limited | Zusammensetzungen zur behandlung und/oder prävention von herz-kreislauf-erkrankungen |
| US20130292242A1 (en) * | 2010-10-13 | 2013-11-07 | Cognis Ip Management Gmbh | Device and method for distilling temperature-sensitive substances |
| NZ727980A (en) | 2010-11-29 | 2018-08-31 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US8951514B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
| US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
| CN102391112B (zh) * | 2011-10-31 | 2014-06-04 | 赵永俊 | 一种工业化生产二十碳五烯酸乙酯的方法 |
| EP2775837A4 (de) | 2011-11-07 | 2015-10-28 | Amarin Pharmaceuticals Ie Ltd | Verfahren zur behandlung von hypertriglyceridämie |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| WO2013083482A1 (en) | 2011-12-05 | 2013-06-13 | Chromacon Ag | Chromatographic method for the separation of fatty acid mixtures |
| ES2891473T3 (es) | 2012-01-06 | 2022-01-28 | Amarin Pharmaceuticals Ie Ltd | Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto |
| PE20241184A1 (es) | 2012-05-14 | 2024-06-03 | Nissui Corp | Acido graso altamente insaturado o ester etilico de acido graso altamente insaturado, con reducidos contaminantes ambientales, y metodo para producir el mismo |
| EP3815684B1 (de) | 2012-06-29 | 2024-09-04 | Amarin Pharmaceuticals Ireland Limited | Verfahren zur verringerung des risikos von herz-kreislauf-ereignissen bei einem patienten in einer statintherapie |
| US9539230B2 (en) * | 2012-09-28 | 2017-01-10 | Mochida Pharmaceutical Co., Ltd. | Composition for reducing new-onset diabetes |
| WO2014074552A2 (en) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
| US9629820B2 (en) | 2012-12-24 | 2017-04-25 | Qualitas Health, Ltd. | Eicosapentaenoic acid (EPA) formulations |
| US10123986B2 (en) | 2012-12-24 | 2018-11-13 | Qualitas Health, Ltd. | Eicosapentaenoic acid (EPA) formulations |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| GB201300354D0 (en) | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| EP2801604B1 (de) | 2013-05-07 | 2017-04-12 | Groupe Novasep | Chromatographisches Verfahren zur Herstellung von hochreinen, mehrfach ungesättigten Fettsäuren |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| CN114410374B (zh) | 2013-12-04 | 2025-01-07 | 株式会社日水 | 微生物油、微生物油的制造方法、浓缩微生物油及浓缩微生物油的制造方法 |
| EP3118186B1 (de) | 2013-12-11 | 2022-02-09 | Novasep Process | Chromatografische anlage zur herstellung von mehrfach ungesättigten fettsäuren |
| US10975031B2 (en) | 2014-01-07 | 2021-04-13 | Novasep Process | Method for purifying aromatic amino acids |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| WO2015195662A1 (en) | 2014-06-16 | 2015-12-23 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| EP3165591B1 (de) * | 2014-07-02 | 2024-05-22 | Nissui Corporation | Verfahren zur herstellung von aus einem meeresprodukt abgeleiteten monovalenten ungesättigten freien fettsäuren oder niedrigen alkoholestern davon |
| CN120623044A (zh) * | 2014-09-17 | 2025-09-12 | 株式会社日水 | 含有二十碳五烯酸烷基酯的组合物及其制造方法 |
| MX2018004128A (es) * | 2015-10-05 | 2018-05-17 | Dsm Ip Assets Bv | Composiciones de aceite y metodos para elaborarlas. |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| WO2018213663A1 (en) | 2017-05-19 | 2018-11-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| ES2983568T3 (es) | 2018-09-24 | 2024-10-23 | Amarin Pharmaceuticals Ie Ltd | Métodos para reducir el riesgo de eventos cardiovasculares en un sujeto |
| CN109438220B (zh) * | 2018-10-31 | 2021-04-13 | 苏州赛分科技有限公司 | 一种从鱼油中纯化epa的方法 |
| EP3666082B1 (de) | 2018-12-12 | 2022-05-04 | Nippon Suisan Kaisha, Ltd. | Zusammensetzung mit einer stark ungesättigten fettsäure oder einem alkylester davon und verfahren zur herstellung davon |
| EP4058141A4 (de) | 2019-11-12 | 2023-11-22 | Amarin Pharmaceuticals Ireland Limited | Verfahren zum verringern des risikos von kardiovaskulären ereignissen bei einem probanden mit vorhofflimmern und/oder vorhofflattern |
| CA3213700A1 (en) | 2021-03-17 | 2022-09-22 | Nissui Corporation | Method of purification and purified products |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
| TW202515986A (zh) | 2023-06-30 | 2025-04-16 | 日商日水股份有限公司 | 含有高度不飽和脂肪酸或其酯衍生物的組合物及其製造方法 |
| CN117800839A (zh) * | 2024-01-08 | 2024-04-02 | 浙江可明生物医药有限公司 | 一种含二十碳五烯酸乙酯的组合物及其制备方法与应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57149400A (en) * | 1981-03-12 | 1982-09-14 | Kureha Chemical Ind Co Ltd | Manufacture of high purity long chain highly unsaturated fatty acid ester |
| JPS588037A (ja) * | 1981-07-03 | 1983-01-18 | Nippon Suisan Kaisha Ltd | エイコサペンタエン酸またはそのエステルの製法 |
| US4377526A (en) * | 1981-05-15 | 1983-03-22 | Nippon Suisan Kaisha, Ltd. | Method of purifying eicosapentaenoic acid and its esters |
| JPS58109444A (ja) * | 1981-11-19 | 1983-06-29 | Kureha Chem Ind Co Ltd | エイコサペンタエン酸又はそのエステル、ドコサヘキサエン酸又はそのエステルの分離精製法 |
| JPS5888339A (ja) * | 1981-11-20 | 1983-05-26 | Kagakuhin Kensa Kyokai | エイコサペンタエン酸又はそのエステルとドコサヘキサエン酸又はそのエステルの分離精製方法 |
| JPS60208940A (ja) * | 1984-03-31 | 1985-10-21 | Nippon Zeon Co Ltd | 長鎮不飽和脂肪酸化合物の分離精製法 |
| JPH0768169B2 (ja) * | 1989-03-30 | 1995-07-26 | 千代田化工建設株式会社 | エイコサペンタエン酸エステル及び／又はドコサヘキサエン酸エステルの分離方法 |
| JPH02268133A (ja) * | 1989-04-10 | 1990-11-01 | Nippon Suisan Kaisha Ltd | エイコサペンタエン酸またはそのエステルの製造法 |
| CA2043615C (en) * | 1990-06-04 | 2001-08-14 | Kazuhiko Hata | Method of producing eicosapentaenoic acid or the ester derivative thereof |
| US5215630A (en) * | 1991-06-04 | 1993-06-01 | Nippon Suisan Kaisha, Ltd. | Method of purifying eicosapentaenoic acid or the ester derivative thereof by fractional distillation |
-
1991
- 1991-10-28 JP JP28168691A patent/JP3400466B2/ja not_active Expired - Lifetime
-
1992
- 1992-10-28 DK DK92922597T patent/DK0610506T3/da active
- 1992-10-28 WO PCT/JP1992/001393 patent/WO1993009210A1/ja not_active Ceased
- 1992-10-28 AT AT92922597T patent/ATE181567T1/de not_active IP Right Cessation
- 1992-10-28 DE DE69229480T patent/DE69229480T2/de not_active Expired - Lifetime
- 1992-10-28 CA CA002122345A patent/CA2122345C/en not_active Expired - Lifetime
- 1992-10-28 AU AU28739/92A patent/AU664866B2/en not_active Expired
- 1992-10-28 EP EP92922597A patent/EP0610506B1/de not_active Expired - Lifetime
- 1992-10-28 ES ES92922597T patent/ES2132133T3/es not_active Expired - Lifetime
- 1992-10-28 US US08/232,021 patent/US5840944A/en not_active Expired - Lifetime
-
1994
- 1994-04-27 NO NO941550A patent/NO302038B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO941550L (de) | 1994-06-27 |
| US5840944A (en) | 1998-11-24 |
| JP3400466B2 (ja) | 2003-04-28 |
| ES2132133T3 (es) | 1999-08-16 |
| EP0610506A1 (de) | 1994-08-17 |
| AU664866B2 (en) | 1995-12-07 |
| JPH05222392A (ja) | 1993-08-31 |
| DE69229480T2 (de) | 2000-02-17 |
| AU2873992A (en) | 1993-06-07 |
| CA2122345C (en) | 2004-03-09 |
| DE69229480D1 (de) | 1999-07-29 |
| NO302038B1 (no) | 1998-01-12 |
| DK0610506T3 (da) | 2000-01-24 |
| WO1993009210A1 (fr) | 1993-05-13 |
| CA2122345A1 (en) | 1993-05-13 |
| EP0610506B1 (de) | 1999-06-23 |
| NO941550D0 (de) | 1994-04-27 |
| EP0610506A4 (en) | 1995-12-13 |
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