DK0610506T3 - Fremgangsmåde til fremstilling af højren eicosapentaensyre eller ester heraf - Google Patents

Fremgangsmåde til fremstilling af højren eicosapentaensyre eller ester heraf

Info

Publication number
DK0610506T3
DK0610506T3 DK92922597T DK92922597T DK0610506T3 DK 0610506 T3 DK0610506 T3 DK 0610506T3 DK 92922597 T DK92922597 T DK 92922597T DK 92922597 T DK92922597 T DK 92922597T DK 0610506 T3 DK0610506 T3 DK 0610506T3
Authority
DK
Denmark
Prior art keywords
eicosapentaenoic acid
ester
preparing
subjecting
esters
Prior art date
Application number
DK92922597T
Other languages
English (en)
Inventor
Kiyomi Furihata
Kazuhiko Hata
Original Assignee
Nippon Suisan Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Suisan Kaisha Ltd filed Critical Nippon Suisan Kaisha Ltd
Application granted granted Critical
Publication of DK0610506T3 publication Critical patent/DK0610506T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining
    • C11C1/10—Refining by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/10—Refining fats or fatty oils by adsorption
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/12—Refining fats or fatty oils by distillation
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
DK92922597T 1991-10-28 1992-10-28 Fremgangsmåde til fremstilling af højren eicosapentaensyre eller ester heraf DK0610506T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28168691A JP3400466B2 (ja) 1991-10-28 1991-10-28 高純度エイコサペンタエン酸またはそのエステルの製造方法
PCT/JP1992/001393 WO1993009210A1 (en) 1991-10-28 1992-10-28 Process for producing high-purity eicosapentaenoic acid or ester thereof

Publications (1)

Publication Number Publication Date
DK0610506T3 true DK0610506T3 (da) 2000-01-24

Family

ID=17642575

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92922597T DK0610506T3 (da) 1991-10-28 1992-10-28 Fremgangsmåde til fremstilling af højren eicosapentaensyre eller ester heraf

Country Status (11)

Country Link
US (1) US5840944A (da)
EP (1) EP0610506B1 (da)
JP (1) JP3400466B2 (da)
AT (1) ATE181567T1 (da)
AU (1) AU664866B2 (da)
CA (1) CA2122345C (da)
DE (1) DE69229480T2 (da)
DK (1) DK0610506T3 (da)
ES (1) ES2132133T3 (da)
NO (1) NO302038B1 (da)
WO (1) WO1993009210A1 (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2097047T3 (es) * 1993-04-29 1997-03-16 Norsk Hydro As Procedimientos para el fraccionamiento cromatografico de acidos grasos y sus derivados.
NZ334852A (en) 1996-10-11 2001-05-25 Scotia Holdings Plc Use and preparation containing eicosapentaenoic acid (EPA; 20:5n-3) for treating schizophrenia
JP2872986B1 (ja) * 1998-01-21 1999-03-24 池田食研株式会社 高純度高度不飽和脂肪酸の低級アルコールエステル精製方法
GB9901809D0 (en) * 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
WO2000050547A1 (en) 1999-02-26 2000-08-31 Monsanto Company Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides
ES2159257B1 (es) * 1999-11-19 2002-04-16 Kd Iqa S L Nuevo procedimiento de preparacion del ester etilico del acido eicosa pentaenoico.
EP1125914A1 (en) 2000-02-14 2001-08-22 Nisshin Flour Milling Co., Ltd. Process for separating and purifying eicosapentaenoic acid or its ester
FR2833006A1 (fr) 2001-11-30 2003-06-06 Cognis France Sa Procede de preparation d'ester methylique d'acide oleique industriel
JP4109893B2 (ja) * 2002-04-24 2008-07-02 株式会社日本触媒 アジリジン類およびｎ−ビニルアミド類の製造方法
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
CA2655956A1 (en) * 2006-06-23 2007-12-27 The Procter & Gamble Company Concentrated and odorless omega 3 fatty acids
KR101357298B1 (ko) * 2008-06-20 2014-01-28 에이케이 앤 엠엔 바이오팜 주식회사 오메가-3계 고도불포화 지방산의 고순도 정제방법
PL2334295T3 (pl) 2008-09-02 2017-12-29 Amarin Pharmaceuticals Ltd Kompozycja farmaceutyczna zawierająca kwas eikozapentaenowy i kwas nikotynowy oraz sposoby jej zastosowania
MX2011008448A (es) 2009-02-10 2012-02-28 Amarin Pharma Inc Uso de ester etilico del acido eisosapentaenoico para tratar hipertrigliceridemia.
CN102458109B (zh) 2009-04-29 2015-02-11 阿马里纳制药公司 稳定的药物组合物和使用其的方法
EP2424521A4 (en) 2009-04-29 2015-03-04 Amarin Pharmaceuticals Ie Ltd PHARMACEUTICAL COMPOSITIONS COMPRISING EPA AND CARDIOVASCULAR AGENT AND METHODS OF USE
KR102012111B1 (ko) 2009-06-15 2019-08-19 아마린 파마, 인크. 병용 스타틴 요법을 받는 대상체에서 ｌｄｌ－ｃ 수준을 상승시키지 않으면서 트리글리세리드를 저하시키기 위한 조성물 및 방법
SG10201405994UA (en) 2009-09-23 2014-10-30 Amarin Pharmaceuticals Ie Ltd Pharmaceutical Composition Comprising Omega-3 Fatty Acid And Hydroxy-derivative Of A Statin And Methods Of Using Same
CA2785742C (en) * 2009-12-30 2015-02-17 Basf Pharma (Callanish) Limited Simulated moving bed chromatographic separation process
EP2542060B1 (en) * 2010-03-04 2019-10-02 Amarin Pharmaceuticals Ireland Limited Compositions for treating and/or preventing cardiovascular disease
US20130292242A1 (en) * 2010-10-13 2013-11-07 Cognis Ip Management Gmbh Device and method for distilling temperature-sensitive substances
NZ712068A (en) 2010-11-29 2017-03-31 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US8951514B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels
US9119826B2 (en) 2011-02-16 2015-09-01 Pivotal Therapeutics, Inc. Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels
ES2395320B1 (es) 2011-07-14 2013-12-18 Soluciones Extractivas Alimentarias, S.L. Nuevo método para la reducción de contaminantes en grasas y aceites a partir de aceites y sus derivados.
CN102391112B (zh) * 2011-10-31 2014-06-04 赵永俊 一种工业化生产二十碳五烯酸乙酯的方法
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd METHODS OF TREATING HYPERTRIGLYCERIDEMIA
WO2013083482A1 (en) 2011-12-05 2013-06-13 Chromacon Ag Chromatographic method for the separation of fatty acid mixtures
WO2013103958A1 (en) 2012-01-06 2013-07-11 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
KR102381331B1 (ko) 2012-05-14 2022-04-01 닛폰 스이산 가부시키가이샤 환경 오염 물질을 저감시킨 고도 불포화 지방산 또는 고도 불포화 지방산 에틸에스테르 및 그 제조 방법
SG11201408769QA (en) 2012-06-29 2015-01-29 Amarin Pharmaceuticals Ie Ltd Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
WO2014050692A1 (ja) * 2012-09-28 2014-04-03 持田製薬株式会社 糖尿病新規発症低減用組成物
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US10123986B2 (en) 2012-12-24 2018-11-13 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US9629820B2 (en) 2012-12-24 2017-04-25 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
EP2801604B1 (en) 2013-05-07 2017-04-12 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
WO2015083806A1 (ja) * 2013-12-04 2015-06-11 日本水産株式会社 微生物油、微生物油の製造方法、濃縮微生物油及び濃縮微生物油の製造方法
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
US10975031B2 (en) 2014-01-07 2021-04-13 Novasep Process Method for purifying aromatic amino acids
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
US10172818B2 (en) 2014-06-16 2019-01-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
JP6651447B2 (ja) * 2014-07-02 2020-02-19 日本水産株式会社 水産物由来遊離１価不飽和脂肪酸又はその低級アルコールエステルの製造方法
JP6664328B2 (ja) * 2014-09-17 2020-03-13 日本水産株式会社 エイコサペンタエン酸アルキルエステルを含有する組成物及びその製造方法
JP6947370B2 (ja) * 2015-10-05 2021-10-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 油組成物および製造方法
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
TW201900160A (zh) 2017-05-19 2019-01-01 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
KR102296068B1 (ko) 2018-09-24 2021-09-02 애머린 파마슈티칼스 아일랜드 리미티드 대상체에서 심혈관 사건의 위험도를 감소시키는 방법
CN109438220B (zh) * 2018-10-31 2021-04-13 苏州赛分科技有限公司 一种从鱼油中纯化epa的方法
ES2915598T3 (es) 2018-12-12 2022-06-23 Nippon Suisan Kaisha Ltd Una composición que contiene un ácido graso altamente insaturado o un éster alquílico del mismo y un método para producirla
US20240075407A1 (en) * 2021-03-17 2024-03-07 Nissui Corporation Method of purification and purified products
KR20240012390A (ko) 2021-04-21 2024-01-29 애머린 파마슈티칼스 아일랜드 리미티드 심부전의 위험을 감소시키는 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57149400A (en) * 1981-03-12 1982-09-14 Kureha Chemical Ind Co Ltd Manufacture of high purity long chain highly unsaturated fatty acid ester
US4377526A (en) * 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
JPS588037A (ja) * 1981-07-03 1983-01-18 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製法
JPS58109444A (ja) * 1981-11-19 1983-06-29 Kureha Chem Ind Co Ltd エイコサペンタエン酸又はそのエステル、ドコサヘキサエン酸又はそのエステルの分離精製法
JPS5888339A (ja) * 1981-11-20 1983-05-26 Kagakuhin Kensa Kyokai エイコサペンタエン酸又はそのエステルとドコサヘキサエン酸又はそのエステルの分離精製方法
JPS60208940A (ja) * 1984-03-31 1985-10-21 Nippon Zeon Co Ltd 長鎮不飽和脂肪酸化合物の分離精製法
JPH0768169B2 (ja) * 1989-03-30 1995-07-26 千代田化工建設株式会社 エイコサペンタエン酸エステル及び／又はドコサヘキサエン酸エステルの分離方法
JPH02268133A (ja) * 1989-04-10 1990-11-01 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製造法
CA2043615C (en) * 1990-06-04 2001-08-14 Kazuhiko Hata Method of producing eicosapentaenoic acid or the ester derivative thereof
US5215630A (en) * 1991-06-04 1993-06-01 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid or the ester derivative thereof by fractional distillation

Also Published As

Publication number Publication date
JPH05222392A (ja) 1993-08-31
ATE181567T1 (de) 1999-07-15
US5840944A (en) 1998-11-24
NO941550L (da) 1994-06-27
DE69229480T2 (de) 2000-02-17
EP0610506B1 (en) 1999-06-23
CA2122345C (en) 2004-03-09
EP0610506A4 (en) 1995-12-13
AU2873992A (en) 1993-06-07
CA2122345A1 (en) 1993-05-13
JP3400466B2 (ja) 2003-04-28
ES2132133T3 (es) 1999-08-16
EP0610506A1 (en) 1994-08-17
AU664866B2 (en) 1995-12-07
WO1993009210A1 (en) 1993-05-13
DE69229480D1 (de) 1999-07-29
NO941550D0 (da) 1994-04-27
NO302038B1 (no) 1998-01-12

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