ATE178893T1 - 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem - Google Patents
6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystemInfo
- Publication number
- ATE178893T1 ATE178893T1 AT91902598T AT91902598T ATE178893T1 AT E178893 T1 ATE178893 T1 AT E178893T1 AT 91902598 T AT91902598 T AT 91902598T AT 91902598 T AT91902598 T AT 91902598T AT E178893 T1 ATE178893 T1 AT E178893T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- nervous system
- central nervous
- trifluoropropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46412690A | 1990-01-11 | 1990-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE178893T1 true ATE178893T1 (de) | 1999-04-15 |
Family
ID=23842674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91902598T ATE178893T1 (de) | 1990-01-11 | 1991-01-08 | 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5288748A (de) |
| EP (1) | EP0510068B1 (de) |
| JP (1) | JP3049089B2 (de) |
| KR (2) | KR100196887B1 (de) |
| AT (1) | ATE178893T1 (de) |
| AU (1) | AU639301B2 (de) |
| CA (1) | CA2073340C (de) |
| DE (1) | DE69131123T2 (de) |
| DK (1) | DK0510068T3 (de) |
| ES (1) | ES2130135T3 (de) |
| GR (1) | GR3030389T3 (de) |
| WO (1) | WO1991011435A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0510068B1 (de) * | 1990-01-11 | 1999-04-14 | PHARMACIA & UPJOHN COMPANY | 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem |
| US5248691A (en) * | 1992-09-03 | 1993-09-28 | Eli Lilly And Company | Furanoindolines |
| GB9223153D0 (en) * | 1992-11-05 | 1992-12-16 | Wyeth John & Brother Ltd | Piperazine derivatives |
| ATE195935T1 (de) * | 1993-03-25 | 2000-09-15 | Upjohn Co | Formyl- oder cyano- substituierte indolderivate mit dopaminergischer wirkung |
| US5512566A (en) * | 1993-10-25 | 1996-04-30 | Ortho Pharmaceutical Corporation | Tricyclic compounds having affinity for the 5-HT1A receptor |
| GB9407919D0 (en) * | 1994-04-21 | 1994-06-15 | Glaxo Group Ltd | Chemical compounds |
| US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| ATE420636T1 (de) * | 1999-05-19 | 2009-01-15 | Painceptor Pharma Corp | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen |
| US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
| DE10121217A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| WO2003010169A1 (en) | 2001-07-25 | 2003-02-06 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene |
| US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| US7227023B2 (en) | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
| TW200524864A (en) * | 2003-11-10 | 2005-08-01 | Wyeth Corp | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands |
| HRP20030959A2 (de) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
| HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
| JP2008543867A (ja) * | 2005-06-17 | 2008-12-04 | ワイス | セロトニン阻害剤ならびに５−ｈｔ１ａアゴニストおよびアンタゴニストとして有用な三環系化合物 |
| CL2007003410A1 (es) * | 2006-11-28 | 2008-04-11 | Wyeth Corp | Compuestos derivados de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina; procedimiento de preparacion; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de trast |
| KR102105539B1 (ko) | 2020-01-15 | 2020-04-28 | 김덕군 | 카메라 모듈 조립용 볼 공급장치 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5117717B2 (de) * | 1971-08-23 | 1976-06-04 | ||
| US4060626A (en) * | 1972-01-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Indole-carboxylic carbon compounds and pharmaceutical compositions containing them |
| DE2740836A1 (de) * | 1977-09-10 | 1979-03-22 | Troponwerke Gmbh & Co Kg | Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4370341A (en) * | 1980-12-11 | 1983-01-25 | Ayerst, Mckenna & Harrison, Ltd. | 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives |
| US4510157A (en) * | 1982-12-27 | 1985-04-09 | Ayerst, Mckenna & Harrison, Inc. | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives |
| DE3333994A1 (de) * | 1983-09-21 | 1985-04-04 | Troponwerke GmbH & Co KG, 5000 Köln | Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| JPS6164173U (de) * | 1984-09-28 | 1986-05-01 | ||
| JPS6475466A (en) * | 1987-09-16 | 1989-03-22 | Agency Ind Science Techn | Indole derivative and production thereof |
| JP3005287B2 (ja) * | 1989-07-13 | 2000-01-31 | ファルマシア・アンド・アップジョン・カンパニー | （１，２ｎ）および（３，２ｎ）―炭素環式―２―アミノテトラリン誘導体 |
| US5486611A (en) * | 1989-07-13 | 1996-01-23 | The Upjohn Company | Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives |
| US5061711A (en) * | 1989-10-09 | 1991-10-29 | Mitsubishi Gas Chemical Company, Inc. | Method of curing liver diseases by using pyrrolo quinoline quinone triesters and novel pyrrolo quinoline quinone triesters |
| EP0510068B1 (de) * | 1990-01-11 | 1999-04-14 | PHARMACIA & UPJOHN COMPANY | 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem |
| AU639536B2 (en) * | 1990-03-15 | 1993-07-29 | Pharmacia & Upjohn Company | Therapeutically useful heterocyclic indole compounds |
| US5223527A (en) * | 1991-07-09 | 1993-06-29 | Neurosearch A/S | Isatineoxime derivatives and their use |
| TW239127B (de) * | 1991-12-20 | 1995-01-21 | Hoffmann La Roche |
-
1991
- 1991-01-08 EP EP91902598A patent/EP0510068B1/de not_active Expired - Lifetime
- 1991-01-08 WO PCT/US1991/000018 patent/WO1991011435A2/en active IP Right Grant
- 1991-01-08 ES ES91902598T patent/ES2130135T3/es not_active Expired - Lifetime
- 1991-01-08 DE DE69131123T patent/DE69131123T2/de not_active Expired - Fee Related
- 1991-01-08 CA CA002073340A patent/CA2073340C/en not_active Expired - Fee Related
- 1991-01-08 JP JP3502958A patent/JP3049089B2/ja not_active Expired - Lifetime
- 1991-01-08 AU AU71754/91A patent/AU639301B2/en not_active Ceased
- 1991-01-08 DK DK91902598T patent/DK0510068T3/da active
- 1991-01-08 AT AT91902598T patent/ATE178893T1/de not_active IP Right Cessation
-
1992
- 1992-07-01 US US07/907,932 patent/US5288748A/en not_active Expired - Fee Related
- 1992-07-10 KR KR1019920701635A patent/KR100196887B1/ko not_active IP Right Cessation
-
1993
- 1993-10-28 US US08/144,857 patent/US5461061A/en not_active Expired - Fee Related
-
1995
- 1995-06-02 US US08/460,449 patent/US5650427A/en not_active Expired - Fee Related
-
1998
- 1998-12-16 KR KR1019980710454A patent/KR100201012B1/ko not_active IP Right Cessation
-
1999
- 1999-06-01 GR GR990401483T patent/GR3030389T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100196887B1 (en) | 1999-06-15 |
| KR100201012B1 (en) | 1999-06-15 |
| US5650427A (en) | 1997-07-22 |
| US5288748A (en) | 1994-02-22 |
| CA2073340C (en) | 1997-05-20 |
| EP0510068A1 (de) | 1992-10-28 |
| AU7175491A (en) | 1991-08-21 |
| ES2130135T3 (es) | 1999-07-01 |
| DK0510068T3 (da) | 1999-10-25 |
| US5461061A (en) | 1995-10-24 |
| GR3030389T3 (en) | 1999-09-30 |
| JPH05503698A (ja) | 1993-06-17 |
| WO1991011435A2 (en) | 1991-08-08 |
| EP0510068B1 (de) | 1999-04-14 |
| DE69131123D1 (de) | 1999-05-20 |
| DE69131123T2 (de) | 1999-09-30 |
| AU639301B2 (en) | 1993-07-22 |
| KR927003586A (ko) | 1992-12-18 |
| JP3049089B2 (ja) | 2000-06-05 |
| WO1991011435A3 (en) | 1991-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |