GR3030389T3 - NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS - Google Patents

NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS

Info

Publication number
GR3030389T3
GR3030389T3 GR990401483T GR990401483T GR3030389T3 GR 3030389 T3 GR3030389 T3 GR 3030389T3 GR 990401483 T GR990401483 T GR 990401483T GR 990401483 T GR990401483 T GR 990401483T GR 3030389 T3 GR3030389 T3 GR 3030389T3
Authority
GR
Greece
Prior art keywords
alkyl
hydrogen
trifluoropropyl
oxazolyl
dihydro
Prior art date
Application number
GR990401483T
Other languages
English (en)
Inventor
Hakan Vilhelm Wikstrom
Per Arvid Emil Carlsson
Bengt Ronny Andersson
Kjell Anders Ivan Svensson
Stig Thomas Elebring
Nils Peter Stjernlof
Arthur Glenn Romero
Susanne Renee Haadsma
Chiu-Hong Lin
Michael Dalton Ennis
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GR3030389T3 publication Critical patent/GR3030389T3/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/62Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GR990401483T 1990-01-11 1999-06-01 NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS GR3030389T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46412690A 1990-01-11 1990-01-11
PCT/US1991/000018 WO1991011435A2 (en) 1990-01-11 1991-01-08 NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS

Publications (1)

Publication Number Publication Date
GR3030389T3 true GR3030389T3 (en) 1999-09-30

Family

ID=23842674

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401483T GR3030389T3 (en) 1990-01-11 1999-06-01 NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS

Country Status (12)

Country Link
US (3) US5288748A (el)
EP (1) EP0510068B1 (el)
JP (1) JP3049089B2 (el)
KR (2) KR100196887B1 (el)
AT (1) ATE178893T1 (el)
AU (1) AU639301B2 (el)
CA (1) CA2073340C (el)
DE (1) DE69131123T2 (el)
DK (1) DK0510068T3 (el)
ES (1) ES2130135T3 (el)
GR (1) GR3030389T3 (el)
WO (1) WO1991011435A2 (el)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2073340C (en) * 1990-01-11 1997-05-20 Hakan Vilhelm Wikstrom Centrally acting 6,7,8,9-tetrahydro-3h-benz(e)indole heterocyclics
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines
GB9223153D0 (en) * 1992-11-05 1992-12-16 Wyeth John & Brother Ltd Piperazine derivatives
EP0690843B1 (en) * 1993-03-25 2000-08-30 PHARMACIA & UPJOHN COMPANY Formyl- or cyano- substituted indole derivatives having dopaminergic activity
US5512566A (en) * 1993-10-25 1996-04-30 Ortho Pharmaceutical Corporation Tricyclic compounds having affinity for the 5-HT1A receptor
GB9407919D0 (en) * 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
AU4910500A (en) * 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
DE10121217A1 (de) 2001-04-30 2002-10-31 Merck Patent Gmbh 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
US7227023B2 (en) 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
TW200524864A (en) * 2003-11-10 2005-08-01 Wyeth Corp Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (el) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
TW200800959A (en) * 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
MX2007015772A (es) * 2005-06-17 2008-02-22 Wyeth Corp Compuestos utiles como inhibidores de serotonina y agonistas y antagonistas de 5-ht-1a.
CL2007003410A1 (es) * 2006-11-28 2008-04-11 Wyeth Corp Compuestos derivados de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina; procedimiento de preparacion; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de trast
KR102105539B1 (ko) 2020-01-15 2020-04-28 김덕군 카메라 모듈 조립용 볼 공급장치

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5117717B2 (el) * 1971-08-23 1976-06-04
US4060626A (en) * 1972-01-26 1977-11-29 Boehringer Mannheim G.M.B.H. Indole-carboxylic carbon compounds and pharmaceutical compositions containing them
DE2740836A1 (de) * 1977-09-10 1979-03-22 Troponwerke Gmbh & Co Kg Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4370341A (en) * 1980-12-11 1983-01-25 Ayerst, Mckenna & Harrison, Ltd. 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives
US4510157A (en) * 1982-12-27 1985-04-09 Ayerst, Mckenna & Harrison, Inc. 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives
DE3333994A1 (de) * 1983-09-21 1985-04-04 Troponwerke GmbH & Co KG, 5000 Köln Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung
JPS6164173U (el) * 1984-09-28 1986-05-01
JPS6475466A (en) * 1987-09-16 1989-03-22 Agency Ind Science Techn Indole derivative and production thereof
KR0151699B1 (ko) * 1989-07-13 1998-10-15 로버트 에이. 아미테이지 (1,2n) 및 (3,2n)-카보사이클릭-2-아미노테트랄린 유도체
US5486611A (en) * 1989-07-13 1996-01-23 The Upjohn Company Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives
US5061711A (en) * 1989-10-09 1991-10-29 Mitsubishi Gas Chemical Company, Inc. Method of curing liver diseases by using pyrrolo quinoline quinone triesters and novel pyrrolo quinoline quinone triesters
CA2073340C (en) * 1990-01-11 1997-05-20 Hakan Vilhelm Wikstrom Centrally acting 6,7,8,9-tetrahydro-3h-benz(e)indole heterocyclics
WO1991013872A1 (en) * 1990-03-15 1991-09-19 The Upjohn Company Therapeutically useful heterocyclic indole compounds
US5223527A (en) * 1991-07-09 1993-06-29 Neurosearch A/S Isatineoxime derivatives and their use
TW239127B (el) * 1991-12-20 1995-01-21 Hoffmann La Roche

Also Published As

Publication number Publication date
KR100201012B1 (en) 1999-06-15
EP0510068A1 (en) 1992-10-28
AU639301B2 (en) 1993-07-22
EP0510068B1 (en) 1999-04-14
CA2073340C (en) 1997-05-20
DE69131123T2 (de) 1999-09-30
WO1991011435A2 (en) 1991-08-08
WO1991011435A3 (en) 1991-09-05
JPH05503698A (ja) 1993-06-17
KR100196887B1 (en) 1999-06-15
AU7175491A (en) 1991-08-21
ES2130135T3 (es) 1999-07-01
DK0510068T3 (da) 1999-10-25
US5650427A (en) 1997-07-22
DE69131123D1 (de) 1999-05-20
JP3049089B2 (ja) 2000-06-05
ATE178893T1 (de) 1999-04-15
US5461061A (en) 1995-10-24
KR927003586A (ko) 1992-12-18
US5288748A (en) 1994-02-22

Similar Documents

Publication Publication Date Title
KR100196887B1 (en) New centrally acting 6,7,8,9-tetrahydro-3h-benz(e) indole heterocyclics
DK0690843T3 (da) Fornyl- eller cyanosubstituerede indolderivater med dopaninerg aktivitet
HU905133D0 (en) Process for producing n-phenyl-alkyl substituted alpha-amino-carboxamide derivatives and pharmaceutical preparatives containing these compounds
TW341565B (en) Indole derivatives processes and intermediates for their preparation and pharmaceutical compositions containing them
KR910002817A (ko) 항균제로서 유용한 아미노메틸옥소옥사졸리디닐 아릴벤젠 유도체
UA42669A (uk) Антагоністи ангіотензину ii, спосіб їх отримання (варіанти), проміжна сполука (варіанти), спосіб їх отримання та фармацевтична композиція
DK0712387T3 (da) 2-Aminoindaner som selektive dopamin-D3-ligander
NO942304L (el)
HUT59661A (en) Process for producing 3-cycloalkyl-propan-amides and pharamaceutical compositions containing them as active components
SE8505715L (sv) Indolderivat
HU912552D0 (en) Process for producing n-sulfonyl-indoline derivatives
ES459865A1 (es) Procedimiento para preparar nuevos derivados de indol.
ES2000706A6 (es) Procedimiento de preparacion de nuevas benzamidas y su sales
NZ501785A (en) 4-(3,4-dihydro-2-naphthylmethyl)- or 4-(2H-3-chromenylmethyl)-4,5-dihydro-1H-imidazole derivatives
KR910007875A (ko) 도파민 길항제로서의 벤질피롤리딘 유도체
MY100599A (en) Derivatives of cycloalkanols and cycloalkenols
GR3035703T3 (en) Use of phenoxy pyridine derivatives for the treatment of illnesses caused by disorders of the dopamine system
RO89787A (ro) Procedeu pentru prepararea unor chinazolinone substituite
HU894471D0 (en) Process for the preparation of 15-amino-20,21-dinor-eburnamenine derivatives and pharmaceutical compositions containing them
JO1572B1 (en) New aminocytone compounds
TW349945B (en) Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic
TH9480EX (th) อนุพันธ์ต่าง ๆ ของ 3-ไอซอกซาโซลอน, การเตรียมของสารเหล่านี้และการใช้สารเหล่านี้รักษาโรค