DK0510068T3 - Nye 6,7,8,9-tetrahydro-3H-benz(e)indol-heterocycler med virkning på centralnervesystemet - Google Patents
Nye 6,7,8,9-tetrahydro-3H-benz(e)indol-heterocycler med virkning på centralnervesystemetInfo
- Publication number
- DK0510068T3 DK0510068T3 DK91902598T DK91902598T DK0510068T3 DK 0510068 T3 DK0510068 T3 DK 0510068T3 DK 91902598 T DK91902598 T DK 91902598T DK 91902598 T DK91902598 T DK 91902598T DK 0510068 T3 DK0510068 T3 DK 0510068T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- hydrogen
- nervous system
- central nervous
- trifluoropropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46412690A | 1990-01-11 | 1990-01-11 | |
PCT/US1991/000018 WO1991011435A2 (en) | 1990-01-11 | 1991-01-08 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0510068T3 true DK0510068T3 (da) | 1999-10-25 |
Family
ID=23842674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91902598T DK0510068T3 (da) | 1990-01-11 | 1991-01-08 | Nye 6,7,8,9-tetrahydro-3H-benz(e)indol-heterocycler med virkning på centralnervesystemet |
Country Status (12)
Country | Link |
---|---|
US (3) | US5288748A (de) |
EP (1) | EP0510068B1 (de) |
JP (1) | JP3049089B2 (de) |
KR (2) | KR100196887B1 (de) |
AT (1) | ATE178893T1 (de) |
AU (1) | AU639301B2 (de) |
CA (1) | CA2073340C (de) |
DE (1) | DE69131123T2 (de) |
DK (1) | DK0510068T3 (de) |
ES (1) | ES2130135T3 (de) |
GR (1) | GR3030389T3 (de) |
WO (1) | WO1991011435A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2130135T3 (es) * | 1990-01-11 | 1999-07-01 | Upjohn Co | Nuevos compuestos heterociclicos de 6,7,8,9-tetrahidro-3h-benz(e)indol con actividad terapeutica sobre el sistema nervioso central. |
US5248691A (en) * | 1992-09-03 | 1993-09-28 | Eli Lilly And Company | Furanoindolines |
GB9223153D0 (en) * | 1992-11-05 | 1992-12-16 | Wyeth John & Brother Ltd | Piperazine derivatives |
ES2149869T3 (es) * | 1993-03-25 | 2000-11-16 | Upjohn Co | Derivados de indol sustituidos por formil o ciano con actividad dopominergica. |
US5512566A (en) * | 1993-10-25 | 1996-04-30 | Ortho Pharmaceutical Corporation | Tricyclic compounds having affinity for the 5-HT1A receptor |
GB9407919D0 (en) * | 1994-04-21 | 1994-06-15 | Glaxo Group Ltd | Chemical compounds |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
DE60041399D1 (de) * | 1999-05-19 | 2009-03-05 | Painceptor Pharma Corp | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen |
US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
DE10121217A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
WO2003010169A1 (en) | 2001-07-25 | 2003-02-06 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene |
US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
US7227023B2 (en) | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
TW200524864A (en) * | 2003-11-10 | 2005-08-01 | Wyeth Corp | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands |
HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030959A2 (de) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
BRPI0611948A2 (pt) * | 2005-06-17 | 2010-10-13 | Wyeth Corp | compostos úteis como inibidores de serotonina e agonistas de antagonista de 5-ht1a |
TW200831096A (en) * | 2006-11-28 | 2008-08-01 | Wyeth Corp | Metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl} quinoline and methods of preparation and uses thereof |
KR102105539B1 (ko) | 2020-01-15 | 2020-04-28 | 김덕군 | 카메라 모듈 조립용 볼 공급장치 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5117717B2 (de) * | 1971-08-23 | 1976-06-04 | ||
US4060626A (en) * | 1972-01-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Indole-carboxylic carbon compounds and pharmaceutical compositions containing them |
DE2740836A1 (de) * | 1977-09-10 | 1979-03-22 | Troponwerke Gmbh & Co Kg | Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4370341A (en) * | 1980-12-11 | 1983-01-25 | Ayerst, Mckenna & Harrison, Ltd. | 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives |
US4510157A (en) * | 1982-12-27 | 1985-04-09 | Ayerst, Mckenna & Harrison, Inc. | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives |
DE3333994A1 (de) * | 1983-09-21 | 1985-04-04 | Troponwerke GmbH & Co KG, 5000 Köln | Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung |
JPS6164173U (de) * | 1984-09-28 | 1986-05-01 | ||
JPS6475466A (en) * | 1987-09-16 | 1989-03-22 | Agency Ind Science Techn | Indole derivative and production thereof |
US5486611A (en) * | 1989-07-13 | 1996-01-23 | The Upjohn Company | Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives |
EP0482084B1 (de) * | 1989-07-13 | 1997-05-07 | PHARMACIA & UPJOHN COMPANY | (1,2n) und (3,2n)-karbozyklische-2-amino-tetralinderivate |
US5061711A (en) * | 1989-10-09 | 1991-10-29 | Mitsubishi Gas Chemical Company, Inc. | Method of curing liver diseases by using pyrrolo quinoline quinone triesters and novel pyrrolo quinoline quinone triesters |
ES2130135T3 (es) * | 1990-01-11 | 1999-07-01 | Upjohn Co | Nuevos compuestos heterociclicos de 6,7,8,9-tetrahidro-3h-benz(e)indol con actividad terapeutica sobre el sistema nervioso central. |
AU639536B2 (en) * | 1990-03-15 | 1993-07-29 | Pharmacia & Upjohn Company | Therapeutically useful heterocyclic indole compounds |
US5223527A (en) * | 1991-07-09 | 1993-06-29 | Neurosearch A/S | Isatineoxime derivatives and their use |
TW239127B (de) * | 1991-12-20 | 1995-01-21 | Hoffmann La Roche |
-
1991
- 1991-01-08 ES ES91902598T patent/ES2130135T3/es not_active Expired - Lifetime
- 1991-01-08 CA CA002073340A patent/CA2073340C/en not_active Expired - Fee Related
- 1991-01-08 DK DK91902598T patent/DK0510068T3/da active
- 1991-01-08 JP JP3502958A patent/JP3049089B2/ja not_active Expired - Lifetime
- 1991-01-08 AU AU71754/91A patent/AU639301B2/en not_active Ceased
- 1991-01-08 AT AT91902598T patent/ATE178893T1/de not_active IP Right Cessation
- 1991-01-08 DE DE69131123T patent/DE69131123T2/de not_active Expired - Fee Related
- 1991-01-08 WO PCT/US1991/000018 patent/WO1991011435A2/en active IP Right Grant
- 1991-01-08 EP EP91902598A patent/EP0510068B1/de not_active Expired - Lifetime
-
1992
- 1992-07-01 US US07/907,932 patent/US5288748A/en not_active Expired - Fee Related
- 1992-07-10 KR KR1019920701635A patent/KR100196887B1/ko not_active IP Right Cessation
-
1993
- 1993-10-28 US US08/144,857 patent/US5461061A/en not_active Expired - Fee Related
-
1995
- 1995-06-02 US US08/460,449 patent/US5650427A/en not_active Expired - Fee Related
-
1998
- 1998-12-16 KR KR1019980710454A patent/KR100201012B1/ko not_active IP Right Cessation
-
1999
- 1999-06-01 GR GR990401483T patent/GR3030389T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69131123D1 (de) | 1999-05-20 |
WO1991011435A3 (en) | 1991-09-05 |
GR3030389T3 (en) | 1999-09-30 |
ATE178893T1 (de) | 1999-04-15 |
DE69131123T2 (de) | 1999-09-30 |
AU7175491A (en) | 1991-08-21 |
AU639301B2 (en) | 1993-07-22 |
US5288748A (en) | 1994-02-22 |
KR100196887B1 (en) | 1999-06-15 |
EP0510068B1 (de) | 1999-04-14 |
EP0510068A1 (de) | 1992-10-28 |
JPH05503698A (ja) | 1993-06-17 |
JP3049089B2 (ja) | 2000-06-05 |
CA2073340C (en) | 1997-05-20 |
ES2130135T3 (es) | 1999-07-01 |
US5461061A (en) | 1995-10-24 |
KR100201012B1 (en) | 1999-06-15 |
KR927003586A (ko) | 1992-12-18 |
US5650427A (en) | 1997-07-22 |
WO1991011435A2 (en) | 1991-08-08 |
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