ATE176868T1 - Stabilisierte aufbereitung monoklonaler menschlicher cln-igg antikörper - Google Patents
Stabilisierte aufbereitung monoklonaler menschlicher cln-igg antikörperInfo
- Publication number
- ATE176868T1 ATE176868T1 AT92915866T AT92915866T ATE176868T1 AT E176868 T1 ATE176868 T1 AT E176868T1 AT 92915866 T AT92915866 T AT 92915866T AT 92915866 T AT92915866 T AT 92915866T AT E176868 T1 ATE176868 T1 AT E176868T1
- Authority
- AT
- Austria
- Prior art keywords
- igg antibodies
- monoclonal human
- stabilized preparation
- state
- monoclonal antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3204743A JP2966592B2 (ja) | 1991-07-20 | 1991-07-20 | 安定化されたヒトモノクローナル抗体製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE176868T1 true ATE176868T1 (de) | 1999-03-15 |
Family
ID=16495593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92915866T ATE176868T1 (de) | 1991-07-20 | 1992-07-17 | Stabilisierte aufbereitung monoklonaler menschlicher cln-igg antikörper |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0597101B1 (de) |
JP (1) | JP2966592B2 (de) |
AT (1) | ATE176868T1 (de) |
AU (1) | AU662010B2 (de) |
DE (1) | DE69228474T2 (de) |
WO (1) | WO1993001835A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1082368C (zh) * | 1995-03-21 | 2002-04-10 | 应用研究系统Ars股份公司 | 人绒毛膜促性腺激素液体制剂 |
WO1996029095A1 (en) * | 1995-03-21 | 1996-09-26 | Applied Research Systems Ars Holding N.V. | Hcg liquid formulations |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
SI0972520T1 (sl) * | 1997-01-30 | 2006-02-28 | Bioph Biotech Entw Pharm Gmbh | Liofiliziran sestavek humanega kostnega morfogenetskega proteina MP52 |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
AU2001277781A1 (en) * | 2000-08-11 | 2002-02-25 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing preparations |
ES2332402T5 (es) | 2000-10-12 | 2018-05-14 | Genentech, Inc. | Formulaciones de proteína concentradas de viscosidad reducida |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
EP2311489A3 (de) | 2002-02-14 | 2013-08-21 | Chugai Seiyaku Kabushiki Kaisha | Formularierung Antikörper-enthaltender Lösungen die einen Zucker als Stabilisator beinhalten. |
CN1798575A (zh) | 2003-04-04 | 2006-07-05 | 健泰科生物技术公司 | 高浓度抗体和蛋白制剂 |
FR2853551B1 (fr) | 2003-04-09 | 2006-08-04 | Lab Francais Du Fractionnement | Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee |
EP3006463A1 (de) | 2003-10-01 | 2016-04-13 | Kyowa Hakko Kirin Co., Ltd. | Verfahren zur stabilisierung von antikörpern und stabilisierte antikörperzubereitung vom lösungstyp |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
TWI398272B (zh) * | 2005-03-08 | 2013-06-11 | Intervet Int Bv | 化學定義的安定劑 |
US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
AU2010221156A1 (en) | 2009-03-06 | 2011-09-22 | Genentech, Inc. | Antibody formulation |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
BR122019026701B1 (pt) * | 2012-03-26 | 2023-01-24 | Sanofi | Formulações de agentes de ligação à base de igg4 estáveis, kit, e dispositivo ou recipiente pré-cheios |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5347515A (en) * | 1976-10-13 | 1978-04-28 | Green Cross Corp:The | Gamma-globulin pharmaceutical preparation for intravenous injection |
JPS56127320A (en) * | 1980-03-10 | 1981-10-06 | Mochida Pharmaceut Co Ltd | Gamma-globulin pharmaceutical |
US4808621A (en) * | 1986-07-07 | 1989-02-28 | Warner-Lambert Company | Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
JPS6388197A (ja) * | 1986-09-30 | 1988-04-19 | Tosoh Corp | モノクロナル抗体の安定化方法 |
DE69029765T2 (de) * | 1989-07-24 | 1997-05-15 | Bayer Ag | Stabilisierung von hochgereinigten Proteinen |
-
1991
- 1991-07-20 JP JP3204743A patent/JP2966592B2/ja not_active Expired - Fee Related
-
1992
- 1992-07-17 EP EP92915866A patent/EP0597101B1/de not_active Expired - Lifetime
- 1992-07-17 WO PCT/JP1992/000914 patent/WO1993001835A1/ja active IP Right Grant
- 1992-07-17 DE DE69228474T patent/DE69228474T2/de not_active Expired - Fee Related
- 1992-07-17 AU AU23305/92A patent/AU662010B2/en not_active Ceased
- 1992-07-17 AT AT92915866T patent/ATE176868T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0597101B1 (de) | 1999-02-24 |
JP2966592B2 (ja) | 1999-10-25 |
EP0597101A4 (en) | 1994-06-15 |
WO1993001835A1 (en) | 1993-02-04 |
DE69228474T2 (de) | 1999-06-24 |
EP0597101A1 (de) | 1994-05-18 |
JPH0525058A (ja) | 1993-02-02 |
AU662010B2 (en) | 1995-08-17 |
AU2330592A (en) | 1993-02-23 |
DE69228474D1 (de) | 1999-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE176868T1 (de) | Stabilisierte aufbereitung monoklonaler menschlicher cln-igg antikörper | |
Finkelstein et al. | Pathogenesis of experimental cholera: biologic activities of purified procholeragen A | |
ATE122357T1 (de) | Polypeptide mit hormonwachstumsbefreiender wirkung. | |
IE823046L (en) | Stabilised interferon formulations | |
ZA876807B (en) | Monoclonal antibodies against human tumor necrosis factor(tnf),and use thereof | |
ATE112687T1 (de) | Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen. | |
EP0284587A3 (de) | Synthetische Peptid-Antigene für den Nachweis von HIV-1-Infektionen | |
EP0863210A3 (de) | Künstliches Immunglobulinkombinierendes Protein | |
Chupin et al. | Antagonistic effect of LH on FSH-induced superovulation in cattle | |
YU46189B (sh) | Monoklonska antitela i antigen za karcinome pluća čoveka koji ne pripadaju tipu "malih ćelija" | |
OA08749A (fr) | Vaccins dont l'épitope caractéristique est incorporé dans une protéine de picornavirus, notamment de poliovirus. | |
ATE24018T1 (de) | Polysaccharid-antigen aus streptococcus und impfstoffe. | |
IL132414A0 (en) | Type alpha platelet derived growth factor receptor gene | |
RU95112690A (ru) | Препарат интерферона | |
ATE174794T1 (de) | Parenteral anzuwendende aminosäuren enthaltende zubereitungen zur bekämpfung von hypotension und verwandten pathologien | |
DE3751319D1 (de) | VERWENDUNG UND ZUSAMMENSETZUNG ZUR VERBESSERUNG DES "TARGETING" VON ANTIKöRPERN, ANTIKöRPERTEILEN, SOWIE KONJUGATE DERSELBEN. | |
ATE164311T1 (de) | Orale, pharmazeutische zusammensetzungen das ein protein oder peptide, eine antikoerper und polymerkugeln enthalten | |
FR2577048B1 (fr) | Reactif pour le dosage par hemagglutination des anticorps contre les toxines bacteriennes, procede de preparation et son application | |
ES2060695T3 (es) | Concentrados terapeuticos de igm. | |
AU5435990A (en) | Monoclonal antibodies to human glutathione s transferase pi | |
KR900700079A (ko) | 누출방지 리포좀 제제 | |
JPS6461499A (en) | Monoclonal antibody to human papilloma viruses 16 type e7 protein, and production and use thereof | |
MA21448A1 (fr) | Procede de preparation de structures peptidiques et immunogenes les contenant destines au controle de la fertilite. | |
EP0254845A3 (de) | Immun-Stimulation mit Chondroitin-sulfat | |
FI874273A (fi) | Uudet monoklonaaliset vasta-aineet IFN-omegalle, niiden valmistusmenetelmät ja niiden käyttö IFN-omegan puhdistamiseen ja osoittamiseen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |