ATE174917T1 - Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittel - Google Patents
Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittelInfo
- Publication number
- ATE174917T1 ATE174917T1 AT91913666T AT91913666T ATE174917T1 AT E174917 T1 ATE174917 T1 AT E174917T1 AT 91913666 T AT91913666 T AT 91913666T AT 91913666 T AT91913666 T AT 91913666T AT E174917 T1 ATE174917 T1 AT E174917T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- substituted
- hydroxy
- phenyl
- hydrogen
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 hydroxy, carboxyl Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9070791 | 1991-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174917T1 true ATE174917T1 (de) | 1999-01-15 |
Family
ID=14006001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91913666T ATE174917T1 (de) | 1991-04-22 | 1991-08-06 | Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittel |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5688949A (Sortimente) |
| EP (1) | EP0591528B1 (Sortimente) |
| JP (1) | JPH0570353A (Sortimente) |
| KR (1) | KR100191774B1 (Sortimente) |
| AT (1) | ATE174917T1 (Sortimente) |
| AU (1) | AU651986B2 (Sortimente) |
| CA (1) | CA2107479C (Sortimente) |
| DE (1) | DE69130683T2 (Sortimente) |
| DK (1) | DK0591528T3 (Sortimente) |
| ES (1) | ES2126573T3 (Sortimente) |
| TW (1) | TW221434B (Sortimente) |
| WO (1) | WO1992018504A1 (Sortimente) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0628559B1 (en) * | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
| DK0714898T3 (da) * | 1994-06-21 | 2002-03-18 | Otsuka Pharma Co Ltd | Pyrazolo[1,5-a]primidinderivat |
| RU2147584C1 (ru) * | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
| US6664261B2 (en) * | 1996-02-07 | 2003-12-16 | Neurocrine Biosciences, Inc. | Pyrazolopyrimidines as CRF receptor antagonists |
| CN1066448C (zh) * | 1996-06-06 | 2001-05-30 | 株式会社大塚制药工场 | 酰胺衍生物 |
| US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
| US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| HU228962B1 (en) * | 1996-07-24 | 2013-07-29 | Bristol Myers Squibb Pharma Co | Azolo triazines, pharmaceutical compositions containing them and use of the compounds |
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| SI9720045B (sl) * | 1996-07-24 | 2008-02-29 | Bristol Myers Squibb Pharma Co | Azolo triazini in pirimidini |
| HUP9603001A3 (en) * | 1996-10-30 | 1999-07-28 | Richter Gedeon Vegyeszet | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
| WO2000059907A2 (en) | 1999-04-06 | 2000-10-12 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| WO2000059908A2 (en) | 1999-04-06 | 2000-10-12 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
| US20020061897A1 (en) * | 2000-03-30 | 2002-05-23 | Elliott Richard L. | Neuropeptide Y antagonists |
| US6630476B2 (en) | 2000-07-07 | 2003-10-07 | Bristol-Myers Squibb Pharma Company | Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists |
| BR0208241A (pt) * | 2001-03-27 | 2004-04-13 | Neurogen Corp | Composto, composições farmacêutica métodos para o tratamento de ansiedade, depressão, um distúrbio do sono, distúrbio de déficit de atenção, ou demência de alzheimer, para aumentar a potência de um efeito terapêutico de um agente do cns, para determinar a presença ou ausência de receptor de gabaa em uma amostra, e para alterar a atividade de transdução de sinal de receptor de gabaa, e, uso de um composto |
| EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US7196111B2 (en) * | 2002-06-04 | 2007-03-27 | Schering Corporation | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents |
| RU2380369C9 (ru) | 2002-09-04 | 2011-07-10 | Шеринг Корпорейшн | Новые пиразолопиримидины как ингибиторы циклин-зависимой киназы |
| US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US7161003B1 (en) * | 2002-09-04 | 2007-01-09 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| CA2497544C (en) | 2002-09-04 | 2010-11-02 | Schering Corporation | Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors |
| US7084271B2 (en) * | 2002-09-04 | 2006-08-01 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7205308B2 (en) | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| AR041134A1 (es) * | 2002-09-04 | 2005-05-04 | Schering Corp | Pirazolopirimidinas como inhibidores de la quinasa dependiente de ciclina |
| AU2003268385B2 (en) * | 2002-09-04 | 2006-12-21 | Pharmacopeia, Inc. | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US8673924B2 (en) | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| MXPA05008955A (es) | 2003-02-28 | 2006-02-22 | Teijin Pharma Ltd | Derivados de pirazolo [1,5-a] pirimidina. |
| EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| US6949895B2 (en) * | 2003-09-03 | 2005-09-27 | Axcelis Technologies, Inc. | Unipolar electrostatic quadrupole lens and switching methods for charged beam transport |
| PE20051089A1 (es) * | 2004-01-22 | 2006-01-25 | Novartis Ag | Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina |
| CN102379684B (zh) | 2005-04-28 | 2014-11-19 | 普罗透斯数字保健公司 | 药物信息系统 |
| US7700773B2 (en) * | 2005-09-09 | 2010-04-20 | Schering Corporation | 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors |
| EP1940847A2 (en) * | 2005-10-06 | 2008-07-09 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
| CN101321760A (zh) | 2005-10-06 | 2008-12-10 | 先灵公司 | 作为蛋白激酶抑制剂的吡唑并嘧啶 |
| GB0526419D0 (en) * | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| CN101636155A (zh) * | 2006-11-29 | 2010-01-27 | 艾博特公司 | 二酰甘油o-酰基转移酶1型酶的抑制剂 |
| WO2009085983A1 (en) * | 2007-12-19 | 2009-07-09 | Genentech, Inc. | 5-anilinoimidazopyridines and methods of use |
| NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| PT2516008E (pt) * | 2009-12-23 | 2014-07-16 | Univ Leuven Kath | Novos compostos antivirais |
| WO2012047570A1 (en) * | 2010-09-28 | 2012-04-12 | Schering Corporation | Fused tricyclic inhibitors of mammalian target of rapamycin |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| AU2011331301A1 (en) | 2010-11-15 | 2013-05-23 | Katholieke Universiteit Leuven | Antiviral condensed heterocyclic compounds |
| US8633198B1 (en) | 2011-09-20 | 2014-01-21 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| AU2013407264B2 (en) * | 2013-12-11 | 2016-09-29 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza a RNA-dependent RNA polymerase |
| EP3096762B1 (en) * | 2014-01-22 | 2023-06-28 | Curovir Ab | Pyrazolo[1,5-a]pyrimidines as antiviral compounds |
| GB201410817D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D | Therapeutic agents |
| JP2020533376A (ja) * | 2017-09-15 | 2020-11-19 | アドゥロ バイオテック，インク． | ピラゾロピリミジノン化合物およびその使用 |
| DE102018201598A1 (de) * | 2018-02-02 | 2019-08-08 | Beiersdorf Ag | Stabile Wundheilsalbe |
| MX2023004712A (es) | 2020-10-23 | 2023-05-09 | Ildong Pharmaceutical Co Ltd | Compuestos moduladores del cftr, composiciones y usos de estos. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3925385A (en) * | 1972-04-20 | 1975-12-09 | Icn Pharmaceuticals | 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines |
| BE792533A (fr) * | 1971-12-09 | 1973-06-08 | Int Chem & Nuclear Corp | Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation |
| US4026893A (en) * | 1975-11-07 | 1977-05-31 | Squibb & Sons Inc | Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives |
| DE3338292A1 (de) * | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide |
| JPS60100381A (ja) * | 1983-11-04 | 1985-06-04 | Yuasa Battery Co Ltd | 密閉形鉛蓄電池 |
| JPS60100581A (ja) * | 1983-11-07 | 1985-06-04 | S D S Baiotetsuku:Kk | ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法 |
| JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
| JP2585462B2 (ja) * | 1989-10-25 | 1997-02-26 | 株式会社大塚製薬工場 | ピラゾロ［１，５―ａ］ピリミジン誘導体 |
| CA2100514C (en) * | 1992-07-29 | 2005-03-29 | Johannes A. M. Hamersma | 17-spiromethylene steroids |
-
1991
- 1991-08-06 DE DE69130683T patent/DE69130683T2/de not_active Expired - Fee Related
- 1991-08-06 AU AU82958/91A patent/AU651986B2/en not_active Ceased
- 1991-08-06 CA CA002107479A patent/CA2107479C/en not_active Expired - Fee Related
- 1991-08-06 ES ES91913666T patent/ES2126573T3/es not_active Expired - Lifetime
- 1991-08-06 EP EP91913666A patent/EP0591528B1/en not_active Expired - Lifetime
- 1991-08-06 KR KR1019930703210A patent/KR100191774B1/ko not_active Expired - Fee Related
- 1991-08-06 AT AT91913666T patent/ATE174917T1/de not_active IP Right Cessation
- 1991-08-06 WO PCT/JP1991/001043 patent/WO1992018504A1/ja not_active Ceased
- 1991-08-06 US US08/133,086 patent/US5688949A/en not_active Expired - Fee Related
- 1991-08-06 DK DK91913666T patent/DK0591528T3/da active
- 1991-08-16 TW TW080106516A patent/TW221434B/zh active
-
1992
- 1992-03-13 JP JP4055370A patent/JPH0570353A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR100191774B1 (ko) | 1999-06-15 |
| ES2126573T3 (es) | 1999-04-01 |
| WO1992018504A1 (en) | 1992-10-29 |
| CA2107479A1 (en) | 1992-10-23 |
| EP0591528B1 (en) | 1998-12-23 |
| TW221434B (Sortimente) | 1994-03-01 |
| AU8295891A (en) | 1992-11-17 |
| EP0591528A4 (en) | 1995-02-15 |
| DK0591528T3 (da) | 1999-08-23 |
| EP0591528A1 (en) | 1994-04-13 |
| US5688949A (en) | 1997-11-18 |
| AU651986B2 (en) | 1994-08-11 |
| DE69130683T2 (de) | 1999-05-06 |
| JPH0570353A (ja) | 1993-03-23 |
| CA2107479C (en) | 1997-12-16 |
| DE69130683D1 (de) | 1999-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |